EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Cancer-associated fibroblasts (CAFs) are recognized potential therapeutic targets, but poor understanding of these heterogeneous cell populations has limited the development of effective treatment strategies. We previously identified tr...

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Veröffentlicht in:	Cancer cell 2024-01, Vol.42 (1), p.101-118.e11
Hauptverfasser:	Mucciolo, Gianluca, Araos Henríquez, Joaquín, Jihad, Muntadher, Pinto Teles, Sara, Manansala, Judhell S., Li, Wenlong, Ashworth, Sally, Lloyd, Eloise G., Cheng, Priscilla S.W., Luo, Weike, Anand, Akanksha, Sawle, Ashley, Piskorz, Anna, Biffi, Giulia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin Animals cancer-associated fibroblasts Carcinoma, Pancreatic Ductal - drug therapy EGFR/ERBB2 signaling metastasis Mice myCAFs Myofibroblasts - pathology pancreatic cancer Pancreatic Neoplasms - drug therapy Signal Transduction TGF-β signaling Transforming Growth Factor beta Tumor Microenvironment
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