Intratracheal administration of programmable DNA nanostructures combats acute lung injury by targeting microRNA-155

The anti-microRNA-155 nucleic acid drugs are massively taken up by alveolar macrophages and dendric cells by pulmonary delivery and silence the overexpressed microRNA-155 in macrophages, exerting excellent anti-inflammatory effects in the ALI mouse model. [Display omitted] Acute lung injury (ALI) is...

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Veröffentlicht in:	International journal of pharmaceutics 2024-02, Vol.651, p.123750-123750, Article 123750
Hauptverfasser:	Huang, Chaowang, Liu, Qian, Xu, Jing, Chen, Chunfa, You, Qianyi, Wang, Dan, Qian, Hang, Hu, Mingdong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury DNA nanostructure Intratracheal administration Macrophage MicroRNA-155
Online-Zugang:	Volltext
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