Structurally defined heparin octasaccharide domain for binding to SARS-CoV-2 Omicron BA.4/BA.5/BA.5.2 spike protein RBD

Heparin, a bio-molecule with the highest negative charge density, is pharmaceutically important to prevent SARS-CoV-2 infection due to its strong competitive binding to spike protein compared with cellular heparan sulfate, which was confirmed as a co-receptor for virus-host cell interaction. Hence,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of biological macromolecules 2024-02, Vol.259 (Pt 1), p.129032-129032, Article 129032
Hauptverfasser:	An, Zizhe, Bu, Changkai, Shi, Deling, Chen, Qingqing, Zhang, Bin, Wang, Qingchi, Jin, Lan, Chi, Lianli
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 Heparin Heparin - chemistry Humans Molecular Docking Simulation Octasaccharide Oligosaccharides - chemistry Omicron Protein Binding SARS-CoV-2 SARS-CoV-2 - metabolism Spike Glycoprotein, Coronavirus - chemistry Spike protein RBD Sulfates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!