Research progress on the association between trimethylamine/trimethylamine-N-oxide and neurological disorders

Research progress on the association between trimethylamine/trimethylamine-N-oxide and neurological disorders

Trimethylamine-N-oxide (TMAO) is a common intestinal metabolite. The Choline in the nutrient forms TMA under the action of the gut microbiota, which passes through the liver and eventually forms TMAO. Initial studies of TMAO focused on cardiovascular disease, but as research progressed, TAMO's...

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Veröffentlicht in:Postgraduate medical journal 2024-04, Vol.100 (1183), p.283-288
Hauptverfasser: Xie, Lizheng, Pan, Li, Liu, Baiyun, Cheng, Hongwei, Mao, Xiang
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Sprache:eng
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Brain-Gut Axis - physiology
Gastrointestinal Microbiome - physiology
Humans
Methylamines - metabolism
Nervous System Diseases - metabolism
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container_issue 1183
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container_title Postgraduate medical journal
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creator Xie, Lizheng
Pan, Li
Liu, Baiyun
Cheng, Hongwei
Mao, Xiang
description Trimethylamine-N-oxide (TMAO) is a common intestinal metabolite. The Choline in the nutrient forms TMA under the action of the gut microbiota, which passes through the liver and eventually forms TMAO. Initial studies of TMAO focused on cardiovascular disease, but as research progressed, TAMO's effects were found to be multisystem and closely related to the development of neurological diseases. Intestinal tract is the organ with the largest concentration of bacteria in human body, and the composition and metabolism of gut microbiota affect human health. As a two-way communication axis connecting the central nervous system and the gastrointestinal tract, the brain-gut axis provides the structural basis for TMAO to play its role. This article will review the correlation between TMA/TMAO and neurological diseases in order to find new directions and new targets for the treatment of neurological diseases.
doi_str_mv 10.1093/postmj/qgad133
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subjects Brain-Gut Axis - physiology
Gastrointestinal Microbiome - physiology
Humans
Methylamines - metabolism
Nervous System Diseases - metabolism
title Research progress on the association between trimethylamine/trimethylamine-N-oxide and neurological disorders
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