Comparison of the calcium signaling alterations in GABA-ergic medium spiny neurons produced from iPSCs of different origins

Disease models based on induced pluripotent stem cells (iPSCs) are in high demand because of their physiological adequacy and well-reproducibility of the pathological phenotype. Nowadays, the most common approach to generate iPSCs is the reprogramming of somatic cells using vectors based on lentivir...

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Veröffentlicht in:	Biochimie 2024-07, Vol.222, p.63-71
Hauptverfasser:	Oshkolova, Arina A., Grekhnev, Dmitriy A., Kruchinina, Anna A., Belikova, Lilia D., Volovikov, Egor A., Lebedeva, Olga S., Bogomazova, Alexandra N., Vigont, Vladimir A., Lagarkova, Maria A., Kaznacheyeva, Elena V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium Signaling Cell Differentiation Cells, Cultured Fibroblasts - cytology Fibroblasts - metabolism Fluorescent calcium imaging GABAergic Neurons - cytology GABAergic Neurons - metabolism Humans Huntington's disease Induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Integrative reprogramming methods Lentivirus - genetics Medium Spiny Neurons Neurons - cytology Neurons - metabolism Non-integrative reprogramming methods Sendai virus Store-operated calcium entry Voltage-gated calcium entry
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