Diabetic complications and risk of depression and anxiety among adults with type 2 diabetes
Aims To investigate if diabetic complications increase the risk of depression and/or anxiety among adults with type 2 diabetes. Methods This register‐based, prospective study included 265,799 adult individuals diagnosed with type 2 diabetes between 1997 and 2017 without a recent history of depressio...
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| Veröffentlicht in: | Diabetic medicine 2024-04, Vol.41 (4), p.e15272-n/a |
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| creator | Horsbøl, Trine Allerslev Hoffmann, Sofie Have Thorsted, Anne Bonde Rosenkilde, Siri Lehn, Sara Fokdal Kofoed‐Enevoldsen, Allan Santos, Monica Iversen, Peter Bindslev Thygesen, Lau Caspar |
| description | Aims
To investigate if diabetic complications increase the risk of depression and/or anxiety among adults with type 2 diabetes.
Methods
This register‐based, prospective study included 265,799 adult individuals diagnosed with type 2 diabetes between 1997 and 2017 without a recent history of depression or anxiety. Diabetic complications included cardiovascular disease, amputation of lower extremities, neuropathy, nephropathy and retinopathy. Both diabetic complications and depression and anxiety were defined by hospital contacts and prescription‐based medication. All individuals were followed from the date of type 2 diabetes diagnosis until the date of incident depression or anxiety, emigration, death or 31 December 2018, whichever occurred first.
Results
The total risk time was 1,915,390 person‐years. The incidence rate of depression and/or anxiety was 3368 per 100,000 person‐years among individuals with diabetic complications and 1929 per 100,000 person‐years among those without. Having or developing any diabetic complication was associated with an increased risk of depression and/or anxiety (HR 1.77, 95% CI 1.73–1.80). The risk for depression and/or anxiety was increased for all types of diabetic complications. The strongest association was found for amputation of lower extremities (HR 2.16, 95% CI 2.01–2.31) and the weakest for retinopathy (HR 1.13, 95% CI 1.09–1.17).
Conclusion
Individuals with type 2 diabetes and diabetic complications are at increased risk of depression and anxiety. This points towards the importance of an increased clinical focus on mental well‐being among individuals with type 2 diabetes and complications. |
| doi_str_mv | 10.1111/dme.15272 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2909083657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2909083657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-cab2af6c817caa093a3eae02b11e2eaaf026a89422f26087c58d5b0a7a4b9be63</originalsourceid><addsrcrecordid>eNp1kEtLw0AQgBdRbK0e_AOy4EUPsfvI5nGUtj6g4kVPHsJkM9GteZlNqPn3rm31IDiXgeHjY_gIOeXsiruZZiVecSVCsUfG3A98T_kx3ydjFvrCkyzkI3Jk7YoxLmIZH5KRjLgKRaTG5GVuIMXOaKrrsimMhs7UlaVQZbQ19p3WOc2wadFad9-cofo02A0Uyrp6pZD1RWfp2nRvtBsapIJmGyXaY3KQQ2HxZLcn5Plm8TS785aPt_ez66WnpZLC05AKyAMd8VADsFiCREAmUs5RIEDORABR7AuRi4BFoVZRplIGIfhpnGIgJ-Ri623a-qNH2yWlsRqLAiqse5uImMUskoEKHXr-B13VfVu57xylAj9yOZWjLreUbmtrW8yTpjUltEPCWfJdPHHFk01xx57tjH1aYvZL_iR2wHQLrE2Bw_-mZP6w2Cq_AA0dijo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2956481115</pqid></control><display><type>article</type><title>Diabetic complications and risk of depression and anxiety among adults with type 2 diabetes</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Horsbøl, Trine Allerslev ; Hoffmann, Sofie Have ; Thorsted, Anne Bonde ; Rosenkilde, Siri ; Lehn, Sara Fokdal ; Kofoed‐Enevoldsen, Allan ; Santos, Monica ; Iversen, Peter Bindslev ; Thygesen, Lau Caspar</creator><creatorcontrib>Horsbøl, Trine Allerslev ; Hoffmann, Sofie Have ; Thorsted, Anne Bonde ; Rosenkilde, Siri ; Lehn, Sara Fokdal ; Kofoed‐Enevoldsen, Allan ; Santos, Monica ; Iversen, Peter Bindslev ; Thygesen, Lau Caspar</creatorcontrib><description>Aims
To investigate if diabetic complications increase the risk of depression and/or anxiety among adults with type 2 diabetes.
Methods
This register‐based, prospective study included 265,799 adult individuals diagnosed with type 2 diabetes between 1997 and 2017 without a recent history of depression or anxiety. Diabetic complications included cardiovascular disease, amputation of lower extremities, neuropathy, nephropathy and retinopathy. Both diabetic complications and depression and anxiety were defined by hospital contacts and prescription‐based medication. All individuals were followed from the date of type 2 diabetes diagnosis until the date of incident depression or anxiety, emigration, death or 31 December 2018, whichever occurred first.
Results
The total risk time was 1,915,390 person‐years. The incidence rate of depression and/or anxiety was 3368 per 100,000 person‐years among individuals with diabetic complications and 1929 per 100,000 person‐years among those without. Having or developing any diabetic complication was associated with an increased risk of depression and/or anxiety (HR 1.77, 95% CI 1.73–1.80). The risk for depression and/or anxiety was increased for all types of diabetic complications. The strongest association was found for amputation of lower extremities (HR 2.16, 95% CI 2.01–2.31) and the weakest for retinopathy (HR 1.13, 95% CI 1.09–1.17).
Conclusion
Individuals with type 2 diabetes and diabetic complications are at increased risk of depression and anxiety. This points towards the importance of an increased clinical focus on mental well‐being among individuals with type 2 diabetes and complications.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.15272</identifier><identifier>PMID: 38157285</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Amputation ; Anxiety ; Anxiety - epidemiology ; Anxiety - etiology ; Cardiovascular diseases ; depression ; Depression - epidemiology ; Depression - etiology ; Diabetes ; Diabetes Complications - epidemiology ; diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; diabetic complications ; Diabetic neuropathy ; Emigration ; epidemiology ; Humans ; Mental depression ; Nephropathy ; Neuropathy ; Prospective Studies ; Retinal Diseases ; Retinopathy ; type 2 ; Well being</subject><ispartof>Diabetic medicine, 2024-04, Vol.41 (4), p.e15272-n/a</ispartof><rights>2023 Diabetes UK.</rights><rights>Diabetic Medicine © 2024 Diabetes UK</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-cab2af6c817caa093a3eae02b11e2eaaf026a89422f26087c58d5b0a7a4b9be63</citedby><cites>FETCH-LOGICAL-c3532-cab2af6c817caa093a3eae02b11e2eaaf026a89422f26087c58d5b0a7a4b9be63</cites><orcidid>0000-0001-6558-2556 ; 0000-0003-2662-2337 ; 0000-0001-7051-1381 ; 0000-0002-1278-9198 ; 0000-0001-8614-0183 ; 0000-0002-9872-6162 ; 0000-0001-7940-6430 ; 0000-0001-8375-5211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdme.15272$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdme.15272$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38157285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horsbøl, Trine Allerslev</creatorcontrib><creatorcontrib>Hoffmann, Sofie Have</creatorcontrib><creatorcontrib>Thorsted, Anne Bonde</creatorcontrib><creatorcontrib>Rosenkilde, Siri</creatorcontrib><creatorcontrib>Lehn, Sara Fokdal</creatorcontrib><creatorcontrib>Kofoed‐Enevoldsen, Allan</creatorcontrib><creatorcontrib>Santos, Monica</creatorcontrib><creatorcontrib>Iversen, Peter Bindslev</creatorcontrib><creatorcontrib>Thygesen, Lau Caspar</creatorcontrib><title>Diabetic complications and risk of depression and anxiety among adults with type 2 diabetes</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims
To investigate if diabetic complications increase the risk of depression and/or anxiety among adults with type 2 diabetes.
Methods
This register‐based, prospective study included 265,799 adult individuals diagnosed with type 2 diabetes between 1997 and 2017 without a recent history of depression or anxiety. Diabetic complications included cardiovascular disease, amputation of lower extremities, neuropathy, nephropathy and retinopathy. Both diabetic complications and depression and anxiety were defined by hospital contacts and prescription‐based medication. All individuals were followed from the date of type 2 diabetes diagnosis until the date of incident depression or anxiety, emigration, death or 31 December 2018, whichever occurred first.
Results
The total risk time was 1,915,390 person‐years. The incidence rate of depression and/or anxiety was 3368 per 100,000 person‐years among individuals with diabetic complications and 1929 per 100,000 person‐years among those without. Having or developing any diabetic complication was associated with an increased risk of depression and/or anxiety (HR 1.77, 95% CI 1.73–1.80). The risk for depression and/or anxiety was increased for all types of diabetic complications. The strongest association was found for amputation of lower extremities (HR 2.16, 95% CI 2.01–2.31) and the weakest for retinopathy (HR 1.13, 95% CI 1.09–1.17).
Conclusion
Individuals with type 2 diabetes and diabetic complications are at increased risk of depression and anxiety. This points towards the importance of an increased clinical focus on mental well‐being among individuals with type 2 diabetes and complications.</description><subject>Adult</subject><subject>Amputation</subject><subject>Anxiety</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety - etiology</subject><subject>Cardiovascular diseases</subject><subject>depression</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Diabetes</subject><subject>Diabetes Complications - epidemiology</subject><subject>diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>diabetic complications</subject><subject>Diabetic neuropathy</subject><subject>Emigration</subject><subject>epidemiology</subject><subject>Humans</subject><subject>Mental depression</subject><subject>Nephropathy</subject><subject>Neuropathy</subject><subject>Prospective Studies</subject><subject>Retinal Diseases</subject><subject>Retinopathy</subject><subject>type 2</subject><subject>Well being</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLw0AQgBdRbK0e_AOy4EUPsfvI5nGUtj6g4kVPHsJkM9GteZlNqPn3rm31IDiXgeHjY_gIOeXsiruZZiVecSVCsUfG3A98T_kx3ydjFvrCkyzkI3Jk7YoxLmIZH5KRjLgKRaTG5GVuIMXOaKrrsimMhs7UlaVQZbQ19p3WOc2wadFad9-cofo02A0Uyrp6pZD1RWfp2nRvtBsapIJmGyXaY3KQQ2HxZLcn5Plm8TS785aPt_ez66WnpZLC05AKyAMd8VADsFiCREAmUs5RIEDORABR7AuRi4BFoVZRplIGIfhpnGIgJ-Ri623a-qNH2yWlsRqLAiqse5uImMUskoEKHXr-B13VfVu57xylAj9yOZWjLreUbmtrW8yTpjUltEPCWfJdPHHFk01xx57tjH1aYvZL_iR2wHQLrE2Bw_-mZP6w2Cq_AA0dijo</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Horsbøl, Trine Allerslev</creator><creator>Hoffmann, Sofie Have</creator><creator>Thorsted, Anne Bonde</creator><creator>Rosenkilde, Siri</creator><creator>Lehn, Sara Fokdal</creator><creator>Kofoed‐Enevoldsen, Allan</creator><creator>Santos, Monica</creator><creator>Iversen, Peter Bindslev</creator><creator>Thygesen, Lau Caspar</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6558-2556</orcidid><orcidid>https://orcid.org/0000-0003-2662-2337</orcidid><orcidid>https://orcid.org/0000-0001-7051-1381</orcidid><orcidid>https://orcid.org/0000-0002-1278-9198</orcidid><orcidid>https://orcid.org/0000-0001-8614-0183</orcidid><orcidid>https://orcid.org/0000-0002-9872-6162</orcidid><orcidid>https://orcid.org/0000-0001-7940-6430</orcidid><orcidid>https://orcid.org/0000-0001-8375-5211</orcidid></search><sort><creationdate>202404</creationdate><title>Diabetic complications and risk of depression and anxiety among adults with type 2 diabetes</title><author>Horsbøl, Trine Allerslev ; Hoffmann, Sofie Have ; Thorsted, Anne Bonde ; Rosenkilde, Siri ; Lehn, Sara Fokdal ; Kofoed‐Enevoldsen, Allan ; Santos, Monica ; Iversen, Peter Bindslev ; Thygesen, Lau Caspar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-cab2af6c817caa093a3eae02b11e2eaaf026a89422f26087c58d5b0a7a4b9be63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Amputation</topic><topic>Anxiety</topic><topic>Anxiety - epidemiology</topic><topic>Anxiety - etiology</topic><topic>Cardiovascular diseases</topic><topic>depression</topic><topic>Depression - epidemiology</topic><topic>Depression - etiology</topic><topic>Diabetes</topic><topic>Diabetes Complications - epidemiology</topic><topic>diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>diabetic complications</topic><topic>Diabetic neuropathy</topic><topic>Emigration</topic><topic>epidemiology</topic><topic>Humans</topic><topic>Mental depression</topic><topic>Nephropathy</topic><topic>Neuropathy</topic><topic>Prospective Studies</topic><topic>Retinal Diseases</topic><topic>Retinopathy</topic><topic>type 2</topic><topic>Well being</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horsbøl, Trine Allerslev</creatorcontrib><creatorcontrib>Hoffmann, Sofie Have</creatorcontrib><creatorcontrib>Thorsted, Anne Bonde</creatorcontrib><creatorcontrib>Rosenkilde, Siri</creatorcontrib><creatorcontrib>Lehn, Sara Fokdal</creatorcontrib><creatorcontrib>Kofoed‐Enevoldsen, Allan</creatorcontrib><creatorcontrib>Santos, Monica</creatorcontrib><creatorcontrib>Iversen, Peter Bindslev</creatorcontrib><creatorcontrib>Thygesen, Lau Caspar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horsbøl, Trine Allerslev</au><au>Hoffmann, Sofie Have</au><au>Thorsted, Anne Bonde</au><au>Rosenkilde, Siri</au><au>Lehn, Sara Fokdal</au><au>Kofoed‐Enevoldsen, Allan</au><au>Santos, Monica</au><au>Iversen, Peter Bindslev</au><au>Thygesen, Lau Caspar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetic complications and risk of depression and anxiety among adults with type 2 diabetes</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2024-04</date><risdate>2024</risdate><volume>41</volume><issue>4</issue><spage>e15272</spage><epage>n/a</epage><pages>e15272-n/a</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><abstract>Aims
To investigate if diabetic complications increase the risk of depression and/or anxiety among adults with type 2 diabetes.
Methods
This register‐based, prospective study included 265,799 adult individuals diagnosed with type 2 diabetes between 1997 and 2017 without a recent history of depression or anxiety. Diabetic complications included cardiovascular disease, amputation of lower extremities, neuropathy, nephropathy and retinopathy. Both diabetic complications and depression and anxiety were defined by hospital contacts and prescription‐based medication. All individuals were followed from the date of type 2 diabetes diagnosis until the date of incident depression or anxiety, emigration, death or 31 December 2018, whichever occurred first.
Results
The total risk time was 1,915,390 person‐years. The incidence rate of depression and/or anxiety was 3368 per 100,000 person‐years among individuals with diabetic complications and 1929 per 100,000 person‐years among those without. Having or developing any diabetic complication was associated with an increased risk of depression and/or anxiety (HR 1.77, 95% CI 1.73–1.80). The risk for depression and/or anxiety was increased for all types of diabetic complications. The strongest association was found for amputation of lower extremities (HR 2.16, 95% CI 2.01–2.31) and the weakest for retinopathy (HR 1.13, 95% CI 1.09–1.17).
Conclusion
Individuals with type 2 diabetes and diabetic complications are at increased risk of depression and anxiety. This points towards the importance of an increased clinical focus on mental well‐being among individuals with type 2 diabetes and complications.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38157285</pmid><doi>10.1111/dme.15272</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6558-2556</orcidid><orcidid>https://orcid.org/0000-0003-2662-2337</orcidid><orcidid>https://orcid.org/0000-0001-7051-1381</orcidid><orcidid>https://orcid.org/0000-0002-1278-9198</orcidid><orcidid>https://orcid.org/0000-0001-8614-0183</orcidid><orcidid>https://orcid.org/0000-0002-9872-6162</orcidid><orcidid>https://orcid.org/0000-0001-7940-6430</orcidid><orcidid>https://orcid.org/0000-0001-8375-5211</orcidid></addata></record> |
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| subjects | Adult Amputation Anxiety Anxiety - epidemiology Anxiety - etiology Cardiovascular diseases depression Depression - epidemiology Depression - etiology Diabetes Diabetes Complications - epidemiology diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology diabetic complications Diabetic neuropathy Emigration epidemiology Humans Mental depression Nephropathy Neuropathy Prospective Studies Retinal Diseases Retinopathy type 2 Well being |
| title | Diabetic complications and risk of depression and anxiety among adults with type 2 diabetes |
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