Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study
This cross-sectional study aimed to determine the relationship between falls and the use of psychotropic medications in patients with rheumatoid arthritis (RA). The psychotropic medication group included patients with RA prescribed psychotropic medications [hypnotics/sedatives, antidepressants, anti...
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| Veröffentlicht in: | Modern rheumatology 2024-12, Vol.35 (1), p.64-71 |
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| creator | Sakurai, Kosuke Yanai, Ryo Isozaki, Takeo Yajima, Nobuyuki |
| description | This cross-sectional study aimed to determine the relationship between falls and the use of psychotropic medications in patients with rheumatoid arthritis (RA).
The psychotropic medication group included patients with RA prescribed psychotropic medications [hypnotics/sedatives, antidepressants, antipsychotics, and anxiolytic (benzodiazepines) drugs]. Poisson regression with robust variance was performed to investigate the relationship between falls and the use of psychotropic medications, with adjustment for age, sex, RA disease activity, stroke, dementia, diabetes mellitus, and osteoarthritis.
Of the 307 patients enrolled, 49 (16.0%) used psychotropic medications and 70 (22.8%) experienced at least one fall per year. Nineteen of the 49 patients (38.8%) taking psychotropic medications and 51 of 258 (19.8%) not taking psychotropic medications experienced at least one fall per year. Falls were significantly more frequent in the group with psychotropic medications than in the group without psychotropic medications (adjusted incidence rate ratio, 1.63; 95% confidence interval, 1.08-2.48; P = .02). No relationship was found between the number of falls and the use of psychotropic medications (adjusted incidence rate ratio, 1.16; 95% confidence interval, 0.39-3.44; P = .78).
There may be a relationship between psychotropic medication use and falls in patients with RA. |
| doi_str_mv | 10.1093/mr/road118 |
| format | Article |
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The psychotropic medication group included patients with RA prescribed psychotropic medications [hypnotics/sedatives, antidepressants, antipsychotics, and anxiolytic (benzodiazepines) drugs]. Poisson regression with robust variance was performed to investigate the relationship between falls and the use of psychotropic medications, with adjustment for age, sex, RA disease activity, stroke, dementia, diabetes mellitus, and osteoarthritis.
Of the 307 patients enrolled, 49 (16.0%) used psychotropic medications and 70 (22.8%) experienced at least one fall per year. Nineteen of the 49 patients (38.8%) taking psychotropic medications and 51 of 258 (19.8%) not taking psychotropic medications experienced at least one fall per year. Falls were significantly more frequent in the group with psychotropic medications than in the group without psychotropic medications (adjusted incidence rate ratio, 1.63; 95% confidence interval, 1.08-2.48; P = .02). No relationship was found between the number of falls and the use of psychotropic medications (adjusted incidence rate ratio, 1.16; 95% confidence interval, 0.39-3.44; P = .78).
There may be a relationship between psychotropic medication use and falls in patients with RA.</description><identifier>ISSN: 1439-7595</identifier><identifier>ISSN: 1439-7609</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.1093/mr/road118</identifier><identifier>PMID: 38156526</identifier><language>eng</language><publisher>England</publisher><subject>Accidental Falls - statistics & numerical data ; Aged ; Aged, 80 and over ; Anti-Anxiety Agents - adverse effects ; Anti-Anxiety Agents - therapeutic use ; Antidepressive Agents - adverse effects ; Antidepressive Agents - therapeutic use ; Antipsychotic Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Arthritis, Rheumatoid - drug therapy ; Cross-Sectional Studies ; Female ; Humans ; Hypnotics and Sedatives - adverse effects ; Hypnotics and Sedatives - therapeutic use ; Male ; Middle Aged ; Psychotropic Drugs - adverse effects ; Psychotropic Drugs - therapeutic use</subject><ispartof>Modern rheumatology, 2024-12, Vol.35 (1), p.64-71</ispartof><rights>Japan College of Rheumatology 2024. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c176t-5f4503fc0f3719739a6f897d0443e00e89158e380c4ce5d0d8fad2699519b6d03</cites><orcidid>0000-0002-8292-3962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38156526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakurai, Kosuke</creatorcontrib><creatorcontrib>Yanai, Ryo</creatorcontrib><creatorcontrib>Isozaki, Takeo</creatorcontrib><creatorcontrib>Yajima, Nobuyuki</creatorcontrib><title>Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description>This cross-sectional study aimed to determine the relationship between falls and the use of psychotropic medications in patients with rheumatoid arthritis (RA).
The psychotropic medication group included patients with RA prescribed psychotropic medications [hypnotics/sedatives, antidepressants, antipsychotics, and anxiolytic (benzodiazepines) drugs]. Poisson regression with robust variance was performed to investigate the relationship between falls and the use of psychotropic medications, with adjustment for age, sex, RA disease activity, stroke, dementia, diabetes mellitus, and osteoarthritis.
Of the 307 patients enrolled, 49 (16.0%) used psychotropic medications and 70 (22.8%) experienced at least one fall per year. Nineteen of the 49 patients (38.8%) taking psychotropic medications and 51 of 258 (19.8%) not taking psychotropic medications experienced at least one fall per year. Falls were significantly more frequent in the group with psychotropic medications than in the group without psychotropic medications (adjusted incidence rate ratio, 1.63; 95% confidence interval, 1.08-2.48; P = .02). No relationship was found between the number of falls and the use of psychotropic medications (adjusted incidence rate ratio, 1.16; 95% confidence interval, 0.39-3.44; P = .78).
There may be a relationship between psychotropic medication use and falls in patients with RA.</description><subject>Accidental Falls - statistics & numerical data</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Anxiety Agents - adverse effects</subject><subject>Anti-Anxiety Agents - therapeutic use</subject><subject>Antidepressive Agents - adverse effects</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - adverse effects</subject><subject>Hypnotics and Sedatives - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psychotropic Drugs - adverse effects</subject><subject>Psychotropic Drugs - therapeutic use</subject><issn>1439-7595</issn><issn>1439-7609</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kcFq3DAQhkVp6CabXPoAQcdS4kZaWbbUWwhJW1gIhPZstNIYK9iWq5HZ-H36oLGb3T0MM_zzMfMzQ8hnzr5xpsVtF29jMI5z9YGc81zorCyY_nispZYrcoH4wpiQWulPZCUUl4XcFOfk3zO0JvnQY-MHuoO0B-hpbdoWqekdTQ3QEYGGmjbT0IfkLd7MneQdDBEQ5_IgDDjZ5gS4OV59aKdFoL6nw7wGZpjufWpobGDsTAp-5mJqok8ev9M7amNAzBDs4sm0FNPopktyNjtCuDrkNfnz-PD7_me2ffrx6_5um1leFimTdS6ZqC2rRcl1KbQpaqVLx_JcAGOgNJcKhGI2tyAdc6o2blNoLbneFY6JNfnyPneI4e8ImKrOo4W2NT2EEauNZopv8uXoa_L1Hf1vOEJdDdF3Jk4VZ9UCVF2sDl-Z4evD3HHXgTuhxzeIN1e9jWE</recordid><startdate>20241225</startdate><enddate>20241225</enddate><creator>Sakurai, Kosuke</creator><creator>Yanai, Ryo</creator><creator>Isozaki, Takeo</creator><creator>Yajima, Nobuyuki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8292-3962</orcidid></search><sort><creationdate>20241225</creationdate><title>Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study</title><author>Sakurai, Kosuke ; Yanai, Ryo ; Isozaki, Takeo ; Yajima, Nobuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c176t-5f4503fc0f3719739a6f897d0443e00e89158e380c4ce5d0d8fad2699519b6d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Accidental Falls - statistics & numerical data</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Anxiety Agents - adverse effects</topic><topic>Anti-Anxiety Agents - therapeutic use</topic><topic>Antidepressive Agents - adverse effects</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - adverse effects</topic><topic>Hypnotics and Sedatives - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psychotropic Drugs - adverse effects</topic><topic>Psychotropic Drugs - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakurai, Kosuke</creatorcontrib><creatorcontrib>Yanai, Ryo</creatorcontrib><creatorcontrib>Isozaki, Takeo</creatorcontrib><creatorcontrib>Yajima, Nobuyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakurai, Kosuke</au><au>Yanai, Ryo</au><au>Isozaki, Takeo</au><au>Yajima, Nobuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study</atitle><jtitle>Modern rheumatology</jtitle><addtitle>Mod Rheumatol</addtitle><date>2024-12-25</date><risdate>2024</risdate><volume>35</volume><issue>1</issue><spage>64</spage><epage>71</epage><pages>64-71</pages><issn>1439-7595</issn><issn>1439-7609</issn><eissn>1439-7609</eissn><abstract>This cross-sectional study aimed to determine the relationship between falls and the use of psychotropic medications in patients with rheumatoid arthritis (RA).
The psychotropic medication group included patients with RA prescribed psychotropic medications [hypnotics/sedatives, antidepressants, antipsychotics, and anxiolytic (benzodiazepines) drugs]. Poisson regression with robust variance was performed to investigate the relationship between falls and the use of psychotropic medications, with adjustment for age, sex, RA disease activity, stroke, dementia, diabetes mellitus, and osteoarthritis.
Of the 307 patients enrolled, 49 (16.0%) used psychotropic medications and 70 (22.8%) experienced at least one fall per year. Nineteen of the 49 patients (38.8%) taking psychotropic medications and 51 of 258 (19.8%) not taking psychotropic medications experienced at least one fall per year. Falls were significantly more frequent in the group with psychotropic medications than in the group without psychotropic medications (adjusted incidence rate ratio, 1.63; 95% confidence interval, 1.08-2.48; P = .02). No relationship was found between the number of falls and the use of psychotropic medications (adjusted incidence rate ratio, 1.16; 95% confidence interval, 0.39-3.44; P = .78).
There may be a relationship between psychotropic medication use and falls in patients with RA.</abstract><cop>England</cop><pmid>38156526</pmid><doi>10.1093/mr/road118</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8292-3962</orcidid></addata></record> |
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| subjects | Accidental Falls - statistics & numerical data Aged Aged, 80 and over Anti-Anxiety Agents - adverse effects Anti-Anxiety Agents - therapeutic use Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Cross-Sectional Studies Female Humans Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - therapeutic use Male Middle Aged Psychotropic Drugs - adverse effects Psychotropic Drugs - therapeutic use |
| title | Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study |
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