The IL-31/TRPV1 pathway mediates allergic asthma exacerbated by DINP dermal exposure in OVA-sensitized Balb/c mice
The potential role of dermal exposure diisononyl phthalate (DINP) as an adjuvant in allergic inflammation and asthma has been suggested. However, the current findings do not provide enough evidence to support this claim. The purpose of this investigation was to examine the impact and mechanisms of a...
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| Veröffentlicht in: | The Science of the total environment 2024-02, Vol.912, p.169613-169613, Article 169613 |
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| creator | Peng, Qi Wu, Yang Li, Yan Lu, Chan Yao, Runming Hu, Siyuan Ma, Ning Chen, Shaohui Yang, Xu Ma, Ping |
| description | The potential role of dermal exposure diisononyl phthalate (DINP) as an adjuvant in allergic inflammation and asthma has been suggested. However, the current findings do not provide enough evidence to support this claim.
The purpose of this investigation was to examine the impact and mechanisms of allergic asthma exacerbation through the dermal exposure to DINP.
The study was undertaken using OVA-sensitized mice. Lung histopathology and airway hyperreactivity (AHR) were assessed. Expression levels of immunoglobulins (t-IgE, OVA-IgE and OVA-IgG1), cytokines (IL-31, IL-4, IL-5, IL-6, IL-13 and INF-γ), and TRPV1 were measured. To investigate the mechanism by which allergic asthma worsens due to dermal exposure to DINP, the blockade analysis using the IL-31 antagonist SB-431542 and the TRPV1 antagonist capsazepine (CZP) were performed.
The findings of the study revealed that the simultaneous exposure to DINP and OVA resulted in an increase in inspiratory resistance (Ri) and expiratory resistance (Re), a decrease in the minimum value of lung dynamic compliance (Cldyn), and worsened airway remodeling. Additionally, it was found that this exposure led to an increase in the levels of IL-31 and TRPV1, which are biomarkers of Th2 cytokines (IL-4, IL-5, IL-6, and IL-13), as well as immunoglobulins (Total IgE, OVA-lgE, and OVA-IgG1), while decreasing the biomarker of Th1 cytokines (IFN-γ). However, these impairments showed improvement after the administration of SB-431542 or CZP.
The findings of this research indicate that the IL-31/TRPV1 pathway plays a moderating function in OVA-induced allergic asthma worsened by dermal exposure to DINP.
[Display omitted]
Dermal exposure to DINP aggravates allergic asthma in Balb/c mice.IL-31/TRPV1 pathway is involved in allergic asthma exacerbated by DINP.Dermal exposure to DINP triggers a Th1/Th2 immune imbalance in Balb/c mice.SB-431542 or capsazepine treatment can alleviate allergic asthma exacerbated by DINP. |
| doi_str_mv | 10.1016/j.scitotenv.2023.169613 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2908123225</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0048969723082438</els_id><sourcerecordid>3040379901</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-86975d88dcfd543a971eda86f86ab0d1c9775c259b9ca38fffa58ff2b91301033</originalsourceid><addsrcrecordid>eNqFkUtvEzEQgC0EoqHwF8BHLpt47H3Yx1AoRIpohUKvlteeJY72EWynkP56HKX0Wh_Gh_nmofkI-QBsDgzqxW4erU9TwvF-zhkXc6hVDeIFmYFsVAGM1y_JjLFSFqpWzQV5E-OO5ddIeE0uhISqrHkzI2GzRbpaFwIWmx-3d0D3Jm3_mCMd0HmTMFLT9xh-eUtNTNvBUPxrLIY25xxtj_Tz6vstdRgG0-fUfoqHgNSP9OZuWUQco0_-IZOfTN8uLB28xbfkVWf6iO8e_0vy8_rL5upbsb75urpargtbsjIVMu9dOSmd7VxVCqMaQGdk3cnatMyBVU1TWV6pVlkjZNd1psqRtwoEAybEJfl47rsP0-8DxqQHHy32vRlxOkQtWMlEoxSDZ1GumAQuOK8y2pxRG6YYA3Z6H_xgwlED0yc3eqef3OiTG312kyvfPw45tPm6T3X_ZWRgeQYwX-XeYzg1wtFmEwFt0m7yzw75B2pRo1Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2908123225</pqid></control><display><type>article</type><title>The IL-31/TRPV1 pathway mediates allergic asthma exacerbated by DINP dermal exposure in OVA-sensitized Balb/c mice</title><source>Elsevier ScienceDirect Journals</source><creator>Peng, Qi ; Wu, Yang ; Li, Yan ; Lu, Chan ; Yao, Runming ; Hu, Siyuan ; Ma, Ning ; Chen, Shaohui ; Yang, Xu ; Ma, Ping</creator><creatorcontrib>Peng, Qi ; Wu, Yang ; Li, Yan ; Lu, Chan ; Yao, Runming ; Hu, Siyuan ; Ma, Ning ; Chen, Shaohui ; Yang, Xu ; Ma, Ping</creatorcontrib><description>The potential role of dermal exposure diisononyl phthalate (DINP) as an adjuvant in allergic inflammation and asthma has been suggested. However, the current findings do not provide enough evidence to support this claim.
The purpose of this investigation was to examine the impact and mechanisms of allergic asthma exacerbation through the dermal exposure to DINP.
The study was undertaken using OVA-sensitized mice. Lung histopathology and airway hyperreactivity (AHR) were assessed. Expression levels of immunoglobulins (t-IgE, OVA-IgE and OVA-IgG1), cytokines (IL-31, IL-4, IL-5, IL-6, IL-13 and INF-γ), and TRPV1 were measured. To investigate the mechanism by which allergic asthma worsens due to dermal exposure to DINP, the blockade analysis using the IL-31 antagonist SB-431542 and the TRPV1 antagonist capsazepine (CZP) were performed.
The findings of the study revealed that the simultaneous exposure to DINP and OVA resulted in an increase in inspiratory resistance (Ri) and expiratory resistance (Re), a decrease in the minimum value of lung dynamic compliance (Cldyn), and worsened airway remodeling. Additionally, it was found that this exposure led to an increase in the levels of IL-31 and TRPV1, which are biomarkers of Th2 cytokines (IL-4, IL-5, IL-6, and IL-13), as well as immunoglobulins (Total IgE, OVA-lgE, and OVA-IgG1), while decreasing the biomarker of Th1 cytokines (IFN-γ). However, these impairments showed improvement after the administration of SB-431542 or CZP.
The findings of this research indicate that the IL-31/TRPV1 pathway plays a moderating function in OVA-induced allergic asthma worsened by dermal exposure to DINP.
[Display omitted]
Dermal exposure to DINP aggravates allergic asthma in Balb/c mice.IL-31/TRPV1 pathway is involved in allergic asthma exacerbated by DINP.Dermal exposure to DINP triggers a Th1/Th2 immune imbalance in Balb/c mice.SB-431542 or capsazepine treatment can alleviate allergic asthma exacerbated by DINP.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2023.169613</identifier><identifier>PMID: 38154627</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>adjuvants ; Allergic asthma ; antagonists ; asthma ; biomarkers ; compliance ; Dermal exposure ; Diisononyl phthalate (DINP) ; environment ; histopathology ; immunoglobulins ; inflammation ; interleukin-13 ; Interleukin-31 (IL-31) ; interleukin-4 ; interleukin-5 ; interleukin-6 ; lungs ; phthalates ; Transient receptor potential vanilloid 1 (TRPV1) ; transient receptor potential vanilloid channels</subject><ispartof>The Science of the total environment, 2024-02, Vol.912, p.169613-169613, Article 169613</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-86975d88dcfd543a971eda86f86ab0d1c9775c259b9ca38fffa58ff2b91301033</citedby><cites>FETCH-LOGICAL-c404t-86975d88dcfd543a971eda86f86ab0d1c9775c259b9ca38fffa58ff2b91301033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2023.169613$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38154627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Qi</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Lu, Chan</creatorcontrib><creatorcontrib>Yao, Runming</creatorcontrib><creatorcontrib>Hu, Siyuan</creatorcontrib><creatorcontrib>Ma, Ning</creatorcontrib><creatorcontrib>Chen, Shaohui</creatorcontrib><creatorcontrib>Yang, Xu</creatorcontrib><creatorcontrib>Ma, Ping</creatorcontrib><title>The IL-31/TRPV1 pathway mediates allergic asthma exacerbated by DINP dermal exposure in OVA-sensitized Balb/c mice</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>The potential role of dermal exposure diisononyl phthalate (DINP) as an adjuvant in allergic inflammation and asthma has been suggested. However, the current findings do not provide enough evidence to support this claim.
The purpose of this investigation was to examine the impact and mechanisms of allergic asthma exacerbation through the dermal exposure to DINP.
The study was undertaken using OVA-sensitized mice. Lung histopathology and airway hyperreactivity (AHR) were assessed. Expression levels of immunoglobulins (t-IgE, OVA-IgE and OVA-IgG1), cytokines (IL-31, IL-4, IL-5, IL-6, IL-13 and INF-γ), and TRPV1 were measured. To investigate the mechanism by which allergic asthma worsens due to dermal exposure to DINP, the blockade analysis using the IL-31 antagonist SB-431542 and the TRPV1 antagonist capsazepine (CZP) were performed.
The findings of the study revealed that the simultaneous exposure to DINP and OVA resulted in an increase in inspiratory resistance (Ri) and expiratory resistance (Re), a decrease in the minimum value of lung dynamic compliance (Cldyn), and worsened airway remodeling. Additionally, it was found that this exposure led to an increase in the levels of IL-31 and TRPV1, which are biomarkers of Th2 cytokines (IL-4, IL-5, IL-6, and IL-13), as well as immunoglobulins (Total IgE, OVA-lgE, and OVA-IgG1), while decreasing the biomarker of Th1 cytokines (IFN-γ). However, these impairments showed improvement after the administration of SB-431542 or CZP.
The findings of this research indicate that the IL-31/TRPV1 pathway plays a moderating function in OVA-induced allergic asthma worsened by dermal exposure to DINP.
[Display omitted]
Dermal exposure to DINP aggravates allergic asthma in Balb/c mice.IL-31/TRPV1 pathway is involved in allergic asthma exacerbated by DINP.Dermal exposure to DINP triggers a Th1/Th2 immune imbalance in Balb/c mice.SB-431542 or capsazepine treatment can alleviate allergic asthma exacerbated by DINP.</description><subject>adjuvants</subject><subject>Allergic asthma</subject><subject>antagonists</subject><subject>asthma</subject><subject>biomarkers</subject><subject>compliance</subject><subject>Dermal exposure</subject><subject>Diisononyl phthalate (DINP)</subject><subject>environment</subject><subject>histopathology</subject><subject>immunoglobulins</subject><subject>inflammation</subject><subject>interleukin-13</subject><subject>Interleukin-31 (IL-31)</subject><subject>interleukin-4</subject><subject>interleukin-5</subject><subject>interleukin-6</subject><subject>lungs</subject><subject>phthalates</subject><subject>Transient receptor potential vanilloid 1 (TRPV1)</subject><subject>transient receptor potential vanilloid channels</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkUtvEzEQgC0EoqHwF8BHLpt47H3Yx1AoRIpohUKvlteeJY72EWynkP56HKX0Wh_Gh_nmofkI-QBsDgzqxW4erU9TwvF-zhkXc6hVDeIFmYFsVAGM1y_JjLFSFqpWzQV5E-OO5ddIeE0uhISqrHkzI2GzRbpaFwIWmx-3d0D3Jm3_mCMd0HmTMFLT9xh-eUtNTNvBUPxrLIY25xxtj_Tz6vstdRgG0-fUfoqHgNSP9OZuWUQco0_-IZOfTN8uLB28xbfkVWf6iO8e_0vy8_rL5upbsb75urpargtbsjIVMu9dOSmd7VxVCqMaQGdk3cnatMyBVU1TWV6pVlkjZNd1psqRtwoEAybEJfl47rsP0-8DxqQHHy32vRlxOkQtWMlEoxSDZ1GumAQuOK8y2pxRG6YYA3Z6H_xgwlED0yc3eqef3OiTG312kyvfPw45tPm6T3X_ZWRgeQYwX-XeYzg1wtFmEwFt0m7yzw75B2pRo1Q</recordid><startdate>20240220</startdate><enddate>20240220</enddate><creator>Peng, Qi</creator><creator>Wu, Yang</creator><creator>Li, Yan</creator><creator>Lu, Chan</creator><creator>Yao, Runming</creator><creator>Hu, Siyuan</creator><creator>Ma, Ning</creator><creator>Chen, Shaohui</creator><creator>Yang, Xu</creator><creator>Ma, Ping</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20240220</creationdate><title>The IL-31/TRPV1 pathway mediates allergic asthma exacerbated by DINP dermal exposure in OVA-sensitized Balb/c mice</title><author>Peng, Qi ; Wu, Yang ; Li, Yan ; Lu, Chan ; Yao, Runming ; Hu, Siyuan ; Ma, Ning ; Chen, Shaohui ; Yang, Xu ; Ma, Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-86975d88dcfd543a971eda86f86ab0d1c9775c259b9ca38fffa58ff2b91301033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>adjuvants</topic><topic>Allergic asthma</topic><topic>antagonists</topic><topic>asthma</topic><topic>biomarkers</topic><topic>compliance</topic><topic>Dermal exposure</topic><topic>Diisononyl phthalate (DINP)</topic><topic>environment</topic><topic>histopathology</topic><topic>immunoglobulins</topic><topic>inflammation</topic><topic>interleukin-13</topic><topic>Interleukin-31 (IL-31)</topic><topic>interleukin-4</topic><topic>interleukin-5</topic><topic>interleukin-6</topic><topic>lungs</topic><topic>phthalates</topic><topic>Transient receptor potential vanilloid 1 (TRPV1)</topic><topic>transient receptor potential vanilloid channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Qi</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Lu, Chan</creatorcontrib><creatorcontrib>Yao, Runming</creatorcontrib><creatorcontrib>Hu, Siyuan</creatorcontrib><creatorcontrib>Ma, Ning</creatorcontrib><creatorcontrib>Chen, Shaohui</creatorcontrib><creatorcontrib>Yang, Xu</creatorcontrib><creatorcontrib>Ma, Ping</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Qi</au><au>Wu, Yang</au><au>Li, Yan</au><au>Lu, Chan</au><au>Yao, Runming</au><au>Hu, Siyuan</au><au>Ma, Ning</au><au>Chen, Shaohui</au><au>Yang, Xu</au><au>Ma, Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The IL-31/TRPV1 pathway mediates allergic asthma exacerbated by DINP dermal exposure in OVA-sensitized Balb/c mice</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2024-02-20</date><risdate>2024</risdate><volume>912</volume><spage>169613</spage><epage>169613</epage><pages>169613-169613</pages><artnum>169613</artnum><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>The potential role of dermal exposure diisononyl phthalate (DINP) as an adjuvant in allergic inflammation and asthma has been suggested. However, the current findings do not provide enough evidence to support this claim.
The purpose of this investigation was to examine the impact and mechanisms of allergic asthma exacerbation through the dermal exposure to DINP.
The study was undertaken using OVA-sensitized mice. Lung histopathology and airway hyperreactivity (AHR) were assessed. Expression levels of immunoglobulins (t-IgE, OVA-IgE and OVA-IgG1), cytokines (IL-31, IL-4, IL-5, IL-6, IL-13 and INF-γ), and TRPV1 were measured. To investigate the mechanism by which allergic asthma worsens due to dermal exposure to DINP, the blockade analysis using the IL-31 antagonist SB-431542 and the TRPV1 antagonist capsazepine (CZP) were performed.
The findings of the study revealed that the simultaneous exposure to DINP and OVA resulted in an increase in inspiratory resistance (Ri) and expiratory resistance (Re), a decrease in the minimum value of lung dynamic compliance (Cldyn), and worsened airway remodeling. Additionally, it was found that this exposure led to an increase in the levels of IL-31 and TRPV1, which are biomarkers of Th2 cytokines (IL-4, IL-5, IL-6, and IL-13), as well as immunoglobulins (Total IgE, OVA-lgE, and OVA-IgG1), while decreasing the biomarker of Th1 cytokines (IFN-γ). However, these impairments showed improvement after the administration of SB-431542 or CZP.
The findings of this research indicate that the IL-31/TRPV1 pathway plays a moderating function in OVA-induced allergic asthma worsened by dermal exposure to DINP.
[Display omitted]
Dermal exposure to DINP aggravates allergic asthma in Balb/c mice.IL-31/TRPV1 pathway is involved in allergic asthma exacerbated by DINP.Dermal exposure to DINP triggers a Th1/Th2 immune imbalance in Balb/c mice.SB-431542 or capsazepine treatment can alleviate allergic asthma exacerbated by DINP.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38154627</pmid><doi>10.1016/j.scitotenv.2023.169613</doi><tpages>1</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | adjuvants Allergic asthma antagonists asthma biomarkers compliance Dermal exposure Diisononyl phthalate (DINP) environment histopathology immunoglobulins inflammation interleukin-13 Interleukin-31 (IL-31) interleukin-4 interleukin-5 interleukin-6 lungs phthalates Transient receptor potential vanilloid 1 (TRPV1) transient receptor potential vanilloid channels |
| title | The IL-31/TRPV1 pathway mediates allergic asthma exacerbated by DINP dermal exposure in OVA-sensitized Balb/c mice |
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