Inefficacy of dietary test substance administration in Amphibian Metamorphosis Assay (AMA) studies

Traditionally, the Amphibian Metamorphosis Assay (AMA; OECD TG 231) is performed by exposing Xenopus laevis tadpoles to test substances dissolved in laboratory water. Recently, the use of dietary administration has been proposed to combat poorly soluble test substances in ecotoxicologically‐based re...

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Veröffentlicht in:	Journal of applied toxicology 2024-05, Vol.44 (5), p.733-746
Hauptverfasser:	Fort, Douglas J., Wolf, Jeffrey C., Langsch, Angelika, Fast, Beate, Junker, Markus, Otter, Rainer
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone Amphibian Metamorphosis Assay Animals Benchmarks Centrifugation Data interpretation Dechlorination Developmental stages Diet Dietary Administration Dietary Sufficiency Drinking water Effectiveness Endocrine disruptors Exposure Hypertrophy Larva Larvae Metamorphosis Metamorphosis, Biological Physical properties Pituitary Solvent Solvents Sunflower oil Survival Thyroid Thyroid Gland Water Xenopus Xenopus laevis
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