Cinchona Alkaloid Polymers Demonstrate Highly Efficient Gene Delivery Dependent on Stereochemistry, Methoxy Substitution, and Length

Nucleic acid delivery with cationic polymers is a promising alternative to expensive viral-based methods; however, it often suffers from a lower performance. Herein, we present a highly efficient delivery system based on cinchona alkaloid natural products copolymerized with 2-hydroxyethyl acrylate....

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Veröffentlicht in:	Biomacromolecules 2024-01, Vol.25 (1), p.486-501
Hauptverfasser:	Kreofsky, Nicholas W., Roy, Punarbasu, Brown, Mary E., Perez, Ulises, Leighton, Ryan E., Frontiera, Renee R., Reineke, Theresa M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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