Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex
Worldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society. Berberis vulgaris L . fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-p...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2024-06, Vol.25 (3), p.507-528 |
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| creator | Golubev, Denis Platonova, Elena Zemskaya, Nadezhda Shevchenko, Oksana Shaposhnikov, Mikhail Nekrasova, Polina Patov, Sergey Ibragimova, Umida Valuisky, Nikita Borisov, Alexander Zhukova, Xenia Sorokina, Svetlana Litvinov, Roman Moskalev, Alexey |
| description | Worldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society.
Berberis vulgaris
L
.
fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of
Berberis vulgaris
L
.
extract. Here we show that extract of
Berberis vulgaris
L
.
can, depending on concentrate, increases lifespan up to 6%, promote healthspan (stress resistance up to 35%, locomotor activity up to 25%, integrity of the intestinal barrier up to 12%, metabolic rate up to 5%) of
Drosophila melanogaster
(in vitro) and exhibits antioxidant (using red blood cell tests) and antiglycation activity (using glycation of bovine serum albumin) (in vitro). In addition to this, the extract does not exhibit cytotoxic properties in vitro, unlike the well-known polyphenolic compound quercetin. qRT-PCR has revealed the involvement of metabolic, heat shock response and lipid metabolism genes in the observed effects. |
| doi_str_mv | 10.1007/s10522-023-10083-6 |
| format | Article |
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Berberis vulgaris
L
.
fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of
Berberis vulgaris
L
.
extract. Here we show that extract of
Berberis vulgaris
L
.
can, depending on concentrate, increases lifespan up to 6%, promote healthspan (stress resistance up to 35%, locomotor activity up to 25%, integrity of the intestinal barrier up to 12%, metabolic rate up to 5%) of
Drosophila melanogaster
(in vitro) and exhibits antioxidant (using red blood cell tests) and antiglycation activity (using glycation of bovine serum albumin) (in vitro). In addition to this, the extract does not exhibit cytotoxic properties in vitro, unlike the well-known polyphenolic compound quercetin. qRT-PCR has revealed the involvement of metabolic, heat shock response and lipid metabolism genes in the observed effects.</description><identifier>ISSN: 1389-5729</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-023-10083-6</identifier><identifier>PMID: 38150086</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Antioxidants ; Antioxidants - pharmacology ; Berberis ; Berberis vulgaris ; Bioactive compounds ; Biomedical and Life Sciences ; Bovine serum albumin ; Cell Biology ; Cytotoxicity ; Developmental Biology ; Dietary Supplements ; Drosophila melanogaster - drug effects ; Drosophila melanogaster - physiology ; Erythrocytes ; Female ; Functional foods & nutraceuticals ; Geriatrics/Gerontology ; Glycosylation ; Heat shock ; Insects ; Life Sciences ; Life span ; Lipid metabolism ; Locomotor activity ; Longevity - drug effects ; Male ; Metabolic rate ; Metabolism ; Plant Extracts - pharmacology ; Quercetin ; Research Article ; Sex Factors</subject><ispartof>Biogerontology (Dordrecht), 2024-06, Vol.25 (3), p.507-528</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-416f8b7bce4b45d63a41cf25dc01ef762ac7d95027c804e22617524226a0c9873</cites><orcidid>0009-0000-8539-6590 ; 0000-0002-0162-0653 ; 0009-0000-3110-0213 ; 0000-0001-9141-4417 ; 0000-0002-3248-1633 ; 0009-0006-7454-8337 ; 0000-0002-8746-0020 ; 0000-0002-4632-2385 ; 0000-0003-0202-0008 ; 0000-0003-0570-8211 ; 0000-0002-5468-989X ; 0000-0001-5331-3201</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10522-023-10083-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10522-023-10083-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38150086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golubev, Denis</creatorcontrib><creatorcontrib>Platonova, Elena</creatorcontrib><creatorcontrib>Zemskaya, Nadezhda</creatorcontrib><creatorcontrib>Shevchenko, Oksana</creatorcontrib><creatorcontrib>Shaposhnikov, Mikhail</creatorcontrib><creatorcontrib>Nekrasova, Polina</creatorcontrib><creatorcontrib>Patov, Sergey</creatorcontrib><creatorcontrib>Ibragimova, Umida</creatorcontrib><creatorcontrib>Valuisky, Nikita</creatorcontrib><creatorcontrib>Borisov, Alexander</creatorcontrib><creatorcontrib>Zhukova, Xenia</creatorcontrib><creatorcontrib>Sorokina, Svetlana</creatorcontrib><creatorcontrib>Litvinov, Roman</creatorcontrib><creatorcontrib>Moskalev, Alexey</creatorcontrib><title>Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex</title><title>Biogerontology (Dordrecht)</title><addtitle>Biogerontology</addtitle><addtitle>Biogerontology</addtitle><description>Worldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society.
Berberis vulgaris
L
.
fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of
Berberis vulgaris
L
.
extract. Here we show that extract of
Berberis vulgaris
L
.
can, depending on concentrate, increases lifespan up to 6%, promote healthspan (stress resistance up to 35%, locomotor activity up to 25%, integrity of the intestinal barrier up to 12%, metabolic rate up to 5%) of
Drosophila melanogaster
(in vitro) and exhibits antioxidant (using red blood cell tests) and antiglycation activity (using glycation of bovine serum albumin) (in vitro). In addition to this, the extract does not exhibit cytotoxic properties in vitro, unlike the well-known polyphenolic compound quercetin. qRT-PCR has revealed the involvement of metabolic, heat shock response and lipid metabolism genes in the observed effects.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Berberis</subject><subject>Berberis vulgaris</subject><subject>Bioactive compounds</subject><subject>Biomedical and Life Sciences</subject><subject>Bovine serum albumin</subject><subject>Cell Biology</subject><subject>Cytotoxicity</subject><subject>Developmental Biology</subject><subject>Dietary Supplements</subject><subject>Drosophila melanogaster - drug effects</subject><subject>Drosophila melanogaster - physiology</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Functional foods & nutraceuticals</subject><subject>Geriatrics/Gerontology</subject><subject>Glycosylation</subject><subject>Heat shock</subject><subject>Insects</subject><subject>Life Sciences</subject><subject>Life span</subject><subject>Lipid metabolism</subject><subject>Locomotor activity</subject><subject>Longevity - drug effects</subject><subject>Male</subject><subject>Metabolic rate</subject><subject>Metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Quercetin</subject><subject>Research Article</subject><subject>Sex Factors</subject><issn>1389-5729</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1TAQjRCIlsIPsECW2LBJ8SOxkyWUp3QlNrC2HGecuPJ1gu1U934Sf8m0twWJBat5nXNmNKeqXjJ6yShVbzOjLec15aLGuhO1fFSds1ZhomT3GHPR9XWreH9WPcv5mlImuWyfVmeiYy0y5Hn16z2kAZLP5GYLk7lNdpcEDiUZW0je1jXAHmIxxS8R-5BKJgmmLZiypCMB58BiC4dlBhK8g7yaSEwcyQwmlPmuXBz5kJa8rLMPBpFp2aaZeCSaiMoHP2IkuNLf-HIkI6wQRx-nB90Mh-fVE2dChhf38aL68enj96sv9e7b569X73a1FVyWumHSdYMaLDRD045SmIZZx9vRUgZOSW6sGvuWcmU72gDnkqmWNxgNtX2nxEX15qS7puXnBrnovc8WQjARli1r3lOpVNMogdDX_0Cvly1FvE4LKrnq8OM9ovgJZfEDOYHTa_J7k46aUX1rpD4ZqdFIfWeklkh6dS-9DXsY_1AenEOAOAEyjuIE6e_u_8j-BiOXrBI</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Golubev, Denis</creator><creator>Platonova, Elena</creator><creator>Zemskaya, Nadezhda</creator><creator>Shevchenko, Oksana</creator><creator>Shaposhnikov, Mikhail</creator><creator>Nekrasova, Polina</creator><creator>Patov, Sergey</creator><creator>Ibragimova, Umida</creator><creator>Valuisky, Nikita</creator><creator>Borisov, Alexander</creator><creator>Zhukova, Xenia</creator><creator>Sorokina, Svetlana</creator><creator>Litvinov, Roman</creator><creator>Moskalev, Alexey</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0000-8539-6590</orcidid><orcidid>https://orcid.org/0000-0002-0162-0653</orcidid><orcidid>https://orcid.org/0009-0000-3110-0213</orcidid><orcidid>https://orcid.org/0000-0001-9141-4417</orcidid><orcidid>https://orcid.org/0000-0002-3248-1633</orcidid><orcidid>https://orcid.org/0009-0006-7454-8337</orcidid><orcidid>https://orcid.org/0000-0002-8746-0020</orcidid><orcidid>https://orcid.org/0000-0002-4632-2385</orcidid><orcidid>https://orcid.org/0000-0003-0202-0008</orcidid><orcidid>https://orcid.org/0000-0003-0570-8211</orcidid><orcidid>https://orcid.org/0000-0002-5468-989X</orcidid><orcidid>https://orcid.org/0000-0001-5331-3201</orcidid></search><sort><creationdate>20240601</creationdate><title>Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex</title><author>Golubev, Denis ; Platonova, Elena ; Zemskaya, Nadezhda ; Shevchenko, Oksana ; Shaposhnikov, Mikhail ; Nekrasova, Polina ; Patov, Sergey ; Ibragimova, Umida ; Valuisky, Nikita ; Borisov, Alexander ; Zhukova, Xenia ; Sorokina, Svetlana ; Litvinov, Roman ; Moskalev, Alexey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-416f8b7bce4b45d63a41cf25dc01ef762ac7d95027c804e22617524226a0c9873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Berberis</topic><topic>Berberis vulgaris</topic><topic>Bioactive compounds</topic><topic>Biomedical and Life Sciences</topic><topic>Bovine serum albumin</topic><topic>Cell Biology</topic><topic>Cytotoxicity</topic><topic>Developmental Biology</topic><topic>Dietary Supplements</topic><topic>Drosophila melanogaster - drug effects</topic><topic>Drosophila melanogaster - physiology</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Functional foods & nutraceuticals</topic><topic>Geriatrics/Gerontology</topic><topic>Glycosylation</topic><topic>Heat shock</topic><topic>Insects</topic><topic>Life Sciences</topic><topic>Life span</topic><topic>Lipid metabolism</topic><topic>Locomotor activity</topic><topic>Longevity - drug effects</topic><topic>Male</topic><topic>Metabolic rate</topic><topic>Metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Quercetin</topic><topic>Research Article</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Golubev, Denis</creatorcontrib><creatorcontrib>Platonova, Elena</creatorcontrib><creatorcontrib>Zemskaya, Nadezhda</creatorcontrib><creatorcontrib>Shevchenko, Oksana</creatorcontrib><creatorcontrib>Shaposhnikov, Mikhail</creatorcontrib><creatorcontrib>Nekrasova, Polina</creatorcontrib><creatorcontrib>Patov, Sergey</creatorcontrib><creatorcontrib>Ibragimova, Umida</creatorcontrib><creatorcontrib>Valuisky, Nikita</creatorcontrib><creatorcontrib>Borisov, Alexander</creatorcontrib><creatorcontrib>Zhukova, Xenia</creatorcontrib><creatorcontrib>Sorokina, Svetlana</creatorcontrib><creatorcontrib>Litvinov, Roman</creatorcontrib><creatorcontrib>Moskalev, Alexey</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golubev, Denis</au><au>Platonova, Elena</au><au>Zemskaya, Nadezhda</au><au>Shevchenko, Oksana</au><au>Shaposhnikov, Mikhail</au><au>Nekrasova, Polina</au><au>Patov, Sergey</au><au>Ibragimova, Umida</au><au>Valuisky, Nikita</au><au>Borisov, Alexander</au><au>Zhukova, Xenia</au><au>Sorokina, Svetlana</au><au>Litvinov, Roman</au><au>Moskalev, Alexey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>25</volume><issue>3</issue><spage>507</spage><epage>528</epage><pages>507-528</pages><issn>1389-5729</issn><eissn>1573-6768</eissn><abstract>Worldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society.
Berberis vulgaris
L
.
fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of
Berberis vulgaris
L
.
extract. Here we show that extract of
Berberis vulgaris
L
.
can, depending on concentrate, increases lifespan up to 6%, promote healthspan (stress resistance up to 35%, locomotor activity up to 25%, integrity of the intestinal barrier up to 12%, metabolic rate up to 5%) of
Drosophila melanogaster
(in vitro) and exhibits antioxidant (using red blood cell tests) and antiglycation activity (using glycation of bovine serum albumin) (in vitro). In addition to this, the extract does not exhibit cytotoxic properties in vitro, unlike the well-known polyphenolic compound quercetin. qRT-PCR has revealed the involvement of metabolic, heat shock response and lipid metabolism genes in the observed effects.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38150086</pmid><doi>10.1007/s10522-023-10083-6</doi><tpages>22</tpages><orcidid>https://orcid.org/0009-0000-8539-6590</orcidid><orcidid>https://orcid.org/0000-0002-0162-0653</orcidid><orcidid>https://orcid.org/0009-0000-3110-0213</orcidid><orcidid>https://orcid.org/0000-0001-9141-4417</orcidid><orcidid>https://orcid.org/0000-0002-3248-1633</orcidid><orcidid>https://orcid.org/0009-0006-7454-8337</orcidid><orcidid>https://orcid.org/0000-0002-8746-0020</orcidid><orcidid>https://orcid.org/0000-0002-4632-2385</orcidid><orcidid>https://orcid.org/0000-0003-0202-0008</orcidid><orcidid>https://orcid.org/0000-0003-0570-8211</orcidid><orcidid>https://orcid.org/0000-0002-5468-989X</orcidid><orcidid>https://orcid.org/0000-0001-5331-3201</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Biogerontology (Dordrecht), 2024-06, Vol.25 (3), p.507-528 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antioxidants Antioxidants - pharmacology Berberis Berberis vulgaris Bioactive compounds Biomedical and Life Sciences Bovine serum albumin Cell Biology Cytotoxicity Developmental Biology Dietary Supplements Drosophila melanogaster - drug effects Drosophila melanogaster - physiology Erythrocytes Female Functional foods & nutraceuticals Geriatrics/Gerontology Glycosylation Heat shock Insects Life Sciences Life span Lipid metabolism Locomotor activity Longevity - drug effects Male Metabolic rate Metabolism Plant Extracts - pharmacology Quercetin Research Article Sex Factors |
| title | Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex |
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