Emerging role of lncRNAs in the etiology of recurrent implantation failure

Recurrent implantation failure (RIF) is a complex clinical entity with several molecular pathways contributing to its pathogenesis. Long non-coding RNAs (lncRNAs) have recently been found to affect the normal implantation, thus aberrant expression of these transcripts is involved in RIF. Altered exp...

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Veröffentlicht in:Pathology, research and practice research and practice, 2024-01, Vol.253, p.155057-155057, Article 155057
Hauptverfasser: Fathi, Mohadeseh, Ghahghaei-Nezamabadi, Akram, Ghafouri-Fard, Soudeh
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Ghahghaei-Nezamabadi, Akram
Ghafouri-Fard, Soudeh
description Recurrent implantation failure (RIF) is a complex clinical entity with several molecular pathways contributing to its pathogenesis. Long non-coding RNAs (lncRNAs) have recently been found to affect the normal implantation, thus aberrant expression of these transcripts is involved in RIF. Altered expression of HOXA11-AS, NONHSAT193031.1, NONHSAT053761.2, NONHSAT083203.2, LUCAT1, PART1, TUNAR, LINC02190, lncSAMD11–1:1 and H19 has been reported in this condition. Moreover, polymorphisms within some lncRNAs have been shown to be associated with miscarriage/RIF. The current review article summarizes the recent data about the role of lncRNAs in RIF. This information would pave the way for identification of the molecular events in this context.
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subjects IVF
LncRNA
RIF
title Emerging role of lncRNAs in the etiology of recurrent implantation failure
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