Maternal serum fatty acid binding protein‐4 level is upregulated in fetal growth restriction with abnormal Doppler flow patterns
Purpose This study aimed to determine fatty acid binding protein‐4 (FABP‐4) concentrations in maternal serum of fetal growth restriction (FGR) pregnancies and controls of normal pregnancies. Furthermore, we hypothesized that the alterations in FABP‐4 levels might correlate with FGR severity. Methods...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2024-03, Vol.50 (3), p.430-437 |
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| creator | Bolluk, Gökhan Oğlak, Süleyman Cemil Kayaoğlu Yıldırım, Zeynep Zengi, Oğuzhan |
| description | Purpose
This study aimed to determine fatty acid binding protein‐4 (FABP‐4) concentrations in maternal serum of fetal growth restriction (FGR) pregnancies and controls of normal pregnancies. Furthermore, we hypothesized that the alterations in FABP‐4 levels might correlate with FGR severity.
Methods
We performed this prospective case–control study with 83 pregnant women. The study groups included 26 FGR pregnancies without abnormal fetal Doppler flow patterns and 25 pregnancies complicated with FGR accompanied by abnormal fetal Doppler flow patterns.
Results
The median serum FABP‐4 concentrations were significantly higher in the FGR cases with abnormal Doppler flow pattern group (2.09 ng/mL) than in the FGR cases without abnormal Doppler flow pattern group (1.62 ng/mL) and the control group (1.20 ng/mL, p |
| doi_str_mv | 10.1111/jog.15868 |
| format | Article |
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This study aimed to determine fatty acid binding protein‐4 (FABP‐4) concentrations in maternal serum of fetal growth restriction (FGR) pregnancies and controls of normal pregnancies. Furthermore, we hypothesized that the alterations in FABP‐4 levels might correlate with FGR severity.
Methods
We performed this prospective case–control study with 83 pregnant women. The study groups included 26 FGR pregnancies without abnormal fetal Doppler flow patterns and 25 pregnancies complicated with FGR accompanied by abnormal fetal Doppler flow patterns.
Results
The median serum FABP‐4 concentrations were significantly higher in the FGR cases with abnormal Doppler flow pattern group (2.09 ng/mL) than in the FGR cases without abnormal Doppler flow pattern group (1.62 ng/mL) and the control group (1.20 ng/mL, p < 0.001). A significant negative correlation was observed between maternal serum FABP‐4 levels and time to birth from blood sample collection (r = −0.356 and p = 0.001), gestational week at birth (r = −0.386 and p < 0.001), and birth weight (r = −0.394 and p < 0.001). A 1.35 ng/mL cut‐off value of serum FABP‐4 level could be used to discriminate FGR cases with a 78.4% sensitivity and 60.6% specificity. The optimal cut‐off value of FABP‐4 levels as an indicator for the diagnosis of FGR with abnormal Doppler flow pattern was estimated to be 1.76 ng/mL, which yielded a sensitivity of 84.0% and a specificity of 75.8%.
Conclusion
FABP‐4 is a crucial biomarker in the diagnosis and determining the severity of pregnancies with restricted fetal growth. We consider that FABP‐4 is a powerful, reliable, and unique biomarker to diagnose FGR pregnancies.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.15868</identifier><identifier>PMID: 38148278</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Biomarkers ; Birth weight ; Diagnosis ; Fatty acid-binding protein ; Fatty acids ; fetal growth assessment ; IUGR ; Pregnancy</subject><ispartof>The journal of obstetrics and gynaecology research, 2024-03, Vol.50 (3), p.430-437</ispartof><rights>2023 Japan Society of Obstetrics and Gynecology.</rights><rights>2024 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3138-8104f85ce9f8404ca94fb615157c077229547c7a4335b70b8788122069f762033</cites><orcidid>0000-0002-2582-7675 ; 0000-0001-7634-3008 ; 0000-0002-3506-6806 ; 0000-0002-4614-5235</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.15868$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.15868$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38148278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bolluk, Gökhan</creatorcontrib><creatorcontrib>Oğlak, Süleyman Cemil</creatorcontrib><creatorcontrib>Kayaoğlu Yıldırım, Zeynep</creatorcontrib><creatorcontrib>Zengi, Oğuzhan</creatorcontrib><title>Maternal serum fatty acid binding protein‐4 level is upregulated in fetal growth restriction with abnormal Doppler flow patterns</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Purpose
This study aimed to determine fatty acid binding protein‐4 (FABP‐4) concentrations in maternal serum of fetal growth restriction (FGR) pregnancies and controls of normal pregnancies. Furthermore, we hypothesized that the alterations in FABP‐4 levels might correlate with FGR severity.
Methods
We performed this prospective case–control study with 83 pregnant women. The study groups included 26 FGR pregnancies without abnormal fetal Doppler flow patterns and 25 pregnancies complicated with FGR accompanied by abnormal fetal Doppler flow patterns.
Results
The median serum FABP‐4 concentrations were significantly higher in the FGR cases with abnormal Doppler flow pattern group (2.09 ng/mL) than in the FGR cases without abnormal Doppler flow pattern group (1.62 ng/mL) and the control group (1.20 ng/mL, p < 0.001). A significant negative correlation was observed between maternal serum FABP‐4 levels and time to birth from blood sample collection (r = −0.356 and p = 0.001), gestational week at birth (r = −0.386 and p < 0.001), and birth weight (r = −0.394 and p < 0.001). A 1.35 ng/mL cut‐off value of serum FABP‐4 level could be used to discriminate FGR cases with a 78.4% sensitivity and 60.6% specificity. The optimal cut‐off value of FABP‐4 levels as an indicator for the diagnosis of FGR with abnormal Doppler flow pattern was estimated to be 1.76 ng/mL, which yielded a sensitivity of 84.0% and a specificity of 75.8%.
Conclusion
FABP‐4 is a crucial biomarker in the diagnosis and determining the severity of pregnancies with restricted fetal growth. We consider that FABP‐4 is a powerful, reliable, and unique biomarker to diagnose FGR pregnancies.</description><subject>Biomarkers</subject><subject>Birth weight</subject><subject>Diagnosis</subject><subject>Fatty acid-binding protein</subject><subject>Fatty acids</subject><subject>fetal growth assessment</subject><subject>IUGR</subject><subject>Pregnancy</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3DAURi1EBRRY8ALIEhu6CNjxb5ZoaKEViA2sI8djB4-cONgJo9lVfQKekSfBw1AWleqNLevcc6_9AXCE0RnO63wR2jPMJJdbYA9TKgokGN_OZ0JxIZHgu-BrSguEsKiw3AG7RGIqSyH3wJ9bNZrYKw-TiVMHrRrHFVTazWHj-rnrWzjEMBrXv_5-odCbZ-OhS3Aaomknn4vn0PXQmjEr2hiW4yOMJo3R6dGFHi5dvlBNH2KXgcswDN5EaH1YwiG3yq3TAfhilU_m8GPfBw8_vt_Proubu6ufs4ubQhNMZCExolYybSorKaJaVdQ2HDPMhEZClGXFqNBCUUJYI1AjhZS4LBGvrOAlImQfnG68-UFPU56x7lzSxnvVmzCluqwQF4JgxjN68g-6CNP6l9YUIVISztbCbxtKx5BSNLYeoutUXNUY1etgclVbvweT2eMP49R0Zv5J_k0iA-cbYOm8Wf3fVP-6u9oo3wBdUJhO</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Bolluk, Gökhan</creator><creator>Oğlak, Süleyman Cemil</creator><creator>Kayaoğlu Yıldırım, Zeynep</creator><creator>Zengi, Oğuzhan</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2582-7675</orcidid><orcidid>https://orcid.org/0000-0001-7634-3008</orcidid><orcidid>https://orcid.org/0000-0002-3506-6806</orcidid><orcidid>https://orcid.org/0000-0002-4614-5235</orcidid></search><sort><creationdate>202403</creationdate><title>Maternal serum fatty acid binding protein‐4 level is upregulated in fetal growth restriction with abnormal Doppler flow patterns</title><author>Bolluk, Gökhan ; Oğlak, Süleyman Cemil ; Kayaoğlu Yıldırım, Zeynep ; Zengi, Oğuzhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3138-8104f85ce9f8404ca94fb615157c077229547c7a4335b70b8788122069f762033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomarkers</topic><topic>Birth weight</topic><topic>Diagnosis</topic><topic>Fatty acid-binding protein</topic><topic>Fatty acids</topic><topic>fetal growth assessment</topic><topic>IUGR</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bolluk, Gökhan</creatorcontrib><creatorcontrib>Oğlak, Süleyman Cemil</creatorcontrib><creatorcontrib>Kayaoğlu Yıldırım, Zeynep</creatorcontrib><creatorcontrib>Zengi, Oğuzhan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolluk, Gökhan</au><au>Oğlak, Süleyman Cemil</au><au>Kayaoğlu Yıldırım, Zeynep</au><au>Zengi, Oğuzhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal serum fatty acid binding protein‐4 level is upregulated in fetal growth restriction with abnormal Doppler flow patterns</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2024-03</date><risdate>2024</risdate><volume>50</volume><issue>3</issue><spage>430</spage><epage>437</epage><pages>430-437</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Purpose
This study aimed to determine fatty acid binding protein‐4 (FABP‐4) concentrations in maternal serum of fetal growth restriction (FGR) pregnancies and controls of normal pregnancies. Furthermore, we hypothesized that the alterations in FABP‐4 levels might correlate with FGR severity.
Methods
We performed this prospective case–control study with 83 pregnant women. The study groups included 26 FGR pregnancies without abnormal fetal Doppler flow patterns and 25 pregnancies complicated with FGR accompanied by abnormal fetal Doppler flow patterns.
Results
The median serum FABP‐4 concentrations were significantly higher in the FGR cases with abnormal Doppler flow pattern group (2.09 ng/mL) than in the FGR cases without abnormal Doppler flow pattern group (1.62 ng/mL) and the control group (1.20 ng/mL, p < 0.001). A significant negative correlation was observed between maternal serum FABP‐4 levels and time to birth from blood sample collection (r = −0.356 and p = 0.001), gestational week at birth (r = −0.386 and p < 0.001), and birth weight (r = −0.394 and p < 0.001). A 1.35 ng/mL cut‐off value of serum FABP‐4 level could be used to discriminate FGR cases with a 78.4% sensitivity and 60.6% specificity. The optimal cut‐off value of FABP‐4 levels as an indicator for the diagnosis of FGR with abnormal Doppler flow pattern was estimated to be 1.76 ng/mL, which yielded a sensitivity of 84.0% and a specificity of 75.8%.
Conclusion
FABP‐4 is a crucial biomarker in the diagnosis and determining the severity of pregnancies with restricted fetal growth. We consider that FABP‐4 is a powerful, reliable, and unique biomarker to diagnose FGR pregnancies.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>38148278</pmid><doi>10.1111/jog.15868</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2582-7675</orcidid><orcidid>https://orcid.org/0000-0001-7634-3008</orcidid><orcidid>https://orcid.org/0000-0002-3506-6806</orcidid><orcidid>https://orcid.org/0000-0002-4614-5235</orcidid></addata></record> |
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| subjects | Biomarkers Birth weight Diagnosis Fatty acid-binding protein Fatty acids fetal growth assessment IUGR Pregnancy |
| title | Maternal serum fatty acid binding protein‐4 level is upregulated in fetal growth restriction with abnormal Doppler flow patterns |
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