Effect of pH, NaCl concentration, and mAb concentration of feed solution on the filterability of Planova™ 20N and Planova™ BioEX

Virus filtration is one of the most important steps in ensuring viral safety during the purification of monoclonal antibodies (mAbs) and other biotherapeutics derived from mammalian cell cultures. Regarding the various virus retentive filters, including Planova filters, a great deal of data has been...

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Veröffentlicht in:	Biotechnology progress 2024-03, Vol.40 (2), p.e3420-e3420
Hauptverfasser:	Hashikawa-Muto, Chie, Yokoyama, Yoshihiro, Hamamoto, Ryo, Kobayashi, Kazuya, Masuda, Yumiko, Nonaka, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Design of experiments Electrostatic properties Feeds Filterability Filters Filtration Membranes Monoclonal antibodies Optimization Retention Sodium chloride Viruses
Online-Zugang:	Volltext
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