Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice

Our previous studies have reported that pre-stimulation of microglia before stress stimulation is a possible strategy to prevent depression-like phenotypes; however, the molecular mechanisms underlying this effect are still unclear. Here, we used β-glucan, a polysaccharide from Saccharomyces cerevis...

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Veröffentlicht in:	European journal of pharmacology 2024-02, Vol.964, p.176288-176288, Article 176288
Hauptverfasser:	Zhao, Cheng, Shi, Ruiting, Lu, Xu, Yang, Rongrong, Chen, Zhuo, Chen, Bingran, Hu, Wenfeng, Ren, Jie, Peng, Jie, Zhu, Tao, Zhu, Haojie, Huang, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Glucans - metabolism beta-Glucans - pharmacology beta-Glucans - therapeutic use Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Depression - metabolism Depression - prevention & control Disease Models, Animal Hippocampus Mice Microglia - metabolism Stress, Psychological - complications Stress, Psychological - metabolism
Online-Zugang:	Volltext
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