Dexamethasone potentiates chimeric antigen receptor T cell persistence and function by enhancing IL-7Rα expression

Dexamethasone (dex) is a glucocorticoid that is a mainstay for the treatment of inflammatory pathologies, including immunotherapy-associated toxicities, yet the specific impact of dex on the activity of CAR T cells is not fully understood. We assessed whether dex treatment given ex vivo or as an adj...

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Veröffentlicht in:	Molecular therapy 2024-02, Vol.32 (2), p.527-539
Hauptverfasser:	Munoz, Ashlie M., Urak, Ryan, Taus, Ellie, Hsieh, Hui-Ju, Awuah, Dennis, Vyas, Vibhuti, Lim, Laura, Jin, Katherine, Lin, Shu-Hong, Priceman, Saul J., Clark, Mary C., Goldberg, Lior, Forman, Stephen J., Wang, Xiuli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CAR CAR T cells chimeric antigen receptor dexamethasone Dexamethasone - pharmacology glucocorticoid Humans IL-7Rα Immunotherapy, Adoptive - methods Mice Neoplasms - pathology Receptors, Antigen, T-Cell - genetics Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism Receptors, Interleukin-7 T-Lymphocytes
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