Assessment of conjunctival, episcleral and scleral thickness in healthy individuals using anterior segment optical coherence tomography
Purpose To determine the thickness of the conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS‐OCT). Methods We prospectively included 107 healthy individuals of different age groups (18–39 years, 40–54 years, 55–69 years and ≥70 years). Fo...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2024-08, Vol.102 (5), p.573-580 |
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| creator | Teeuw, G. J. Vergouwen, D. P. C. Ramdas, W. D. Sanchez‐Brea, L. Andrade De Jesus, D. Rothova, A. Vingerling, J. R. Ten Berge, J. C. |
| description | Purpose
To determine the thickness of the conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS‐OCT).
Methods
We prospectively included 107 healthy individuals of different age groups (18–39 years, 40–54 years, 55–69 years and ≥70 years). For each eye, AS‐OCT scans of four quadrants (temporal, nasal, superior and inferior) were acquired. The thickness of the conjunctiva, episclera and sclera was measured for each scan. In addition, the axial length of both eyes was measured, and general characteristics, including smoking, allergies and contact lens use, were collected.
Results
The mean conjunctival thickness was significantly different between the nasal and superior quadrants (87 ± 30 μm vs. 77 ± 16 μm; p |
| doi_str_mv | 10.1111/aos.16606 |
| format | Article |
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To determine the thickness of the conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS‐OCT).
Methods
We prospectively included 107 healthy individuals of different age groups (18–39 years, 40–54 years, 55–69 years and ≥70 years). For each eye, AS‐OCT scans of four quadrants (temporal, nasal, superior and inferior) were acquired. The thickness of the conjunctiva, episclera and sclera was measured for each scan. In addition, the axial length of both eyes was measured, and general characteristics, including smoking, allergies and contact lens use, were collected.
Results
The mean conjunctival thickness was significantly different between the nasal and superior quadrants (87 ± 30 μm vs. 77 ± 16 μm; p < 0.001), as well as the superior and inferior quadrants (77 ± 16 μm vs. 86 ± 19 μm; p = 0.001). The mean episcleral thickness was larger in the superior (174 ± 54 μm) and inferior (141 ± 43 μm) quadrants, compared to the nasal (83 ± 38 μm) and temporal quadrants (90 ± 44 μm). The mean scleral thickness of the inferior quadrant was the largest (596 ± 64 μm), followed by the nasal (567 ± 76 μm), temporal (516 ± 67 μm) and superior (467 ± 52 μm) quadrants (all p < 0.001). The averaged scleral thickness increased 0.96 μm per age year (0.41–1.47 μm, p < 0.001).
Conclusions
This study provides an assessment of the thickness of scleral and adjacent superficial layers in healthy individuals determined on AS‐OCT, which could enable future research into the use of AS‐OCT in diseases affecting the anterior eye wall.</description><identifier>ISSN: 1755-375X</identifier><identifier>ISSN: 1755-3768</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.16606</identifier><identifier>PMID: 38140822</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Anterior Eye Segment - anatomy & histology ; Anterior Eye Segment - diagnostic imaging ; anterior segment ; Conjunctiva ; Conjunctiva - anatomy & histology ; Conjunctiva - diagnostic imaging ; Eye lens ; Female ; Healthy Volunteers ; Humans ; imaging ; Male ; Middle Aged ; optical coherence tomography ; Prospective Studies ; Reference Values ; sclera ; Sclera - anatomy & histology ; Sclera - diagnostic imaging ; scleral thickness ; Tomography ; Tomography, Optical Coherence - methods ; Young Adult</subject><ispartof>Acta ophthalmologica (Oxford, England), 2024-08, Vol.102 (5), p.573-580</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.</rights><rights>2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3486-d18aba8882c6a5460c582c0d5aa4a6f0a63786039c6ebdfe3cdbc67b432b85873</cites><orcidid>0000-0002-3324-5034 ; 0000-0003-4610-4991 ; 0000-0002-3872-1431 ; 0000-0002-1780-5281 ; 0000-0002-4061-4846</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.16606$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.16606$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38140822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teeuw, G. J.</creatorcontrib><creatorcontrib>Vergouwen, D. P. C.</creatorcontrib><creatorcontrib>Ramdas, W. D.</creatorcontrib><creatorcontrib>Sanchez‐Brea, L.</creatorcontrib><creatorcontrib>Andrade De Jesus, D.</creatorcontrib><creatorcontrib>Rothova, A.</creatorcontrib><creatorcontrib>Vingerling, J. R.</creatorcontrib><creatorcontrib>Ten Berge, J. C.</creatorcontrib><title>Assessment of conjunctival, episcleral and scleral thickness in healthy individuals using anterior segment optical coherence tomography</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To determine the thickness of the conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS‐OCT).
Methods
We prospectively included 107 healthy individuals of different age groups (18–39 years, 40–54 years, 55–69 years and ≥70 years). For each eye, AS‐OCT scans of four quadrants (temporal, nasal, superior and inferior) were acquired. The thickness of the conjunctiva, episclera and sclera was measured for each scan. In addition, the axial length of both eyes was measured, and general characteristics, including smoking, allergies and contact lens use, were collected.
Results
The mean conjunctival thickness was significantly different between the nasal and superior quadrants (87 ± 30 μm vs. 77 ± 16 μm; p < 0.001), as well as the superior and inferior quadrants (77 ± 16 μm vs. 86 ± 19 μm; p = 0.001). The mean episcleral thickness was larger in the superior (174 ± 54 μm) and inferior (141 ± 43 μm) quadrants, compared to the nasal (83 ± 38 μm) and temporal quadrants (90 ± 44 μm). The mean scleral thickness of the inferior quadrant was the largest (596 ± 64 μm), followed by the nasal (567 ± 76 μm), temporal (516 ± 67 μm) and superior (467 ± 52 μm) quadrants (all p < 0.001). The averaged scleral thickness increased 0.96 μm per age year (0.41–1.47 μm, p < 0.001).
Conclusions
This study provides an assessment of the thickness of scleral and adjacent superficial layers in healthy individuals determined on AS‐OCT, which could enable future research into the use of AS‐OCT in diseases affecting the anterior eye wall.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anterior Eye Segment - anatomy & histology</subject><subject>Anterior Eye Segment - diagnostic imaging</subject><subject>anterior segment</subject><subject>Conjunctiva</subject><subject>Conjunctiva - anatomy & histology</subject><subject>Conjunctiva - diagnostic imaging</subject><subject>Eye lens</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>optical coherence tomography</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>sclera</subject><subject>Sclera - anatomy & histology</subject><subject>Sclera - diagnostic imaging</subject><subject>scleral thickness</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Young Adult</subject><issn>1755-375X</issn><issn>1755-3768</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kcFO3DAURa2qqAy0C34AWeqGSh2w49jxLEeIUiSkWZRK3VmO8zLxkNjBTkD5An4blwALJLzxXZx7ZOsidETJKU3nTPt4SoUg4hNa0ILzJSuE_PyW-b99dBDjjhCRqPwL2meS5kRm2QI9rmOEGDtwA_Y1Nt7tRmcGe6_bnxh6G00LQbdYuwq_5qGx5talFrYON6DboZlSrOy9rUbdRjxG67apMkCwPuAI29nfD9akvvENBHAG8OA7vw26b6avaK9OVfj2ch-iv78ubs5_L683l1fn6-ulYbkUy4pKXWopZWaE5rkghqdIKq51rkVNtGCFFIStjICyqoGZqjSiKHOWlZLLgh2ik9nbB383QhxUl_4Ibasd-DGqbEU4zwRf0YR-f4fu_Bhcep1ipBCC0oJlifoxUyb4GAPUqg-202FSlKj_66i0jnpeJ7HHL8ax7KB6I1_nSMDZDDzYFqaPTWq9-TMrnwD12pxJ</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Teeuw, G. J.</creator><creator>Vergouwen, D. P. C.</creator><creator>Ramdas, W. D.</creator><creator>Sanchez‐Brea, L.</creator><creator>Andrade De Jesus, D.</creator><creator>Rothova, A.</creator><creator>Vingerling, J. R.</creator><creator>Ten Berge, J. C.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3324-5034</orcidid><orcidid>https://orcid.org/0000-0003-4610-4991</orcidid><orcidid>https://orcid.org/0000-0002-3872-1431</orcidid><orcidid>https://orcid.org/0000-0002-1780-5281</orcidid><orcidid>https://orcid.org/0000-0002-4061-4846</orcidid></search><sort><creationdate>202408</creationdate><title>Assessment of conjunctival, episcleral and scleral thickness in healthy individuals using anterior segment optical coherence tomography</title><author>Teeuw, G. J. ; Vergouwen, D. P. C. ; Ramdas, W. D. ; Sanchez‐Brea, L. ; Andrade De Jesus, D. ; Rothova, A. ; Vingerling, J. R. ; Ten Berge, J. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3486-d18aba8882c6a5460c582c0d5aa4a6f0a63786039c6ebdfe3cdbc67b432b85873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anterior Eye Segment - anatomy & histology</topic><topic>Anterior Eye Segment - diagnostic imaging</topic><topic>anterior segment</topic><topic>Conjunctiva</topic><topic>Conjunctiva - anatomy & histology</topic><topic>Conjunctiva - diagnostic imaging</topic><topic>Eye lens</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>optical coherence tomography</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>sclera</topic><topic>Sclera - anatomy & histology</topic><topic>Sclera - diagnostic imaging</topic><topic>scleral thickness</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teeuw, G. J.</creatorcontrib><creatorcontrib>Vergouwen, D. P. C.</creatorcontrib><creatorcontrib>Ramdas, W. D.</creatorcontrib><creatorcontrib>Sanchez‐Brea, L.</creatorcontrib><creatorcontrib>Andrade De Jesus, D.</creatorcontrib><creatorcontrib>Rothova, A.</creatorcontrib><creatorcontrib>Vingerling, J. R.</creatorcontrib><creatorcontrib>Ten Berge, J. C.</creatorcontrib><collection>Wiley Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teeuw, G. J.</au><au>Vergouwen, D. P. C.</au><au>Ramdas, W. D.</au><au>Sanchez‐Brea, L.</au><au>Andrade De Jesus, D.</au><au>Rothova, A.</au><au>Vingerling, J. R.</au><au>Ten Berge, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of conjunctival, episcleral and scleral thickness in healthy individuals using anterior segment optical coherence tomography</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2024-08</date><risdate>2024</risdate><volume>102</volume><issue>5</issue><spage>573</spage><epage>580</epage><pages>573-580</pages><issn>1755-375X</issn><issn>1755-3768</issn><eissn>1755-3768</eissn><abstract>Purpose
To determine the thickness of the conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS‐OCT).
Methods
We prospectively included 107 healthy individuals of different age groups (18–39 years, 40–54 years, 55–69 years and ≥70 years). For each eye, AS‐OCT scans of four quadrants (temporal, nasal, superior and inferior) were acquired. The thickness of the conjunctiva, episclera and sclera was measured for each scan. In addition, the axial length of both eyes was measured, and general characteristics, including smoking, allergies and contact lens use, were collected.
Results
The mean conjunctival thickness was significantly different between the nasal and superior quadrants (87 ± 30 μm vs. 77 ± 16 μm; p < 0.001), as well as the superior and inferior quadrants (77 ± 16 μm vs. 86 ± 19 μm; p = 0.001). The mean episcleral thickness was larger in the superior (174 ± 54 μm) and inferior (141 ± 43 μm) quadrants, compared to the nasal (83 ± 38 μm) and temporal quadrants (90 ± 44 μm). The mean scleral thickness of the inferior quadrant was the largest (596 ± 64 μm), followed by the nasal (567 ± 76 μm), temporal (516 ± 67 μm) and superior (467 ± 52 μm) quadrants (all p < 0.001). The averaged scleral thickness increased 0.96 μm per age year (0.41–1.47 μm, p < 0.001).
Conclusions
This study provides an assessment of the thickness of scleral and adjacent superficial layers in healthy individuals determined on AS‐OCT, which could enable future research into the use of AS‐OCT in diseases affecting the anterior eye wall.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38140822</pmid><doi>10.1111/aos.16606</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3324-5034</orcidid><orcidid>https://orcid.org/0000-0003-4610-4991</orcidid><orcidid>https://orcid.org/0000-0002-3872-1431</orcidid><orcidid>https://orcid.org/0000-0002-1780-5281</orcidid><orcidid>https://orcid.org/0000-0002-4061-4846</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta ophthalmologica (Oxford, England), 2024-08, Vol.102 (5), p.573-580 |
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| subjects | Adolescent Adult Aged Anterior Eye Segment - anatomy & histology Anterior Eye Segment - diagnostic imaging anterior segment Conjunctiva Conjunctiva - anatomy & histology Conjunctiva - diagnostic imaging Eye lens Female Healthy Volunteers Humans imaging Male Middle Aged optical coherence tomography Prospective Studies Reference Values sclera Sclera - anatomy & histology Sclera - diagnostic imaging scleral thickness Tomography Tomography, Optical Coherence - methods Young Adult |
| title | Assessment of conjunctival, episcleral and scleral thickness in healthy individuals using anterior segment optical coherence tomography |
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