Repurposing pantoprazole in combination with systemic therapy in advanced head and neck squamous cell carcinoma: a phase I/II randomized study

Pantoprazole decreases the acidity of the tumor microenvironment by inhibiting proton pumps on the cancer cell. This possibly leads to increased sensitivity to cytotoxic therapy. We conducted a phase I/II randomized controlled trial in adult patients with head and neck squamous cell carcinoma (HNSCC...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2023-12, Vol.41 (1), p.26-26, Article 26
Hauptverfasser:	Noronha, Vanita, Patil, Vijay, Menon, Nandini, Kalra, Devanshi, Singh, Ajaykumar, Shah, Minit, Goud, Supriya, Jobanputra, Kunal, Nawale, Kavita, Shah, Srushti, Chowdhury, Oindrila Roy, Mathrudev, Vijayalakshmi, Jogdhankar, Shweta, Singh, Madhu Yadav, Singh, Ashish, Adak, Supriya, Sandesh, Mayuri, Arunkumar, R., Kumar, Suman, Mahajan, Abhishek, Prabhash, Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemotherapy Head & neck cancer Hematology Internal Medicine Medicine Medicine & Public Health Oncology Original Paper Pathology Squamous cell carcinoma
Online-Zugang:	Volltext
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