Electrophoretically Co-Deposited Collagen-Lactoferrin Membranes with Enhanced Pro-Regenerative Properties for Oral Soft Tissue Regeneration
The quality of soft tissue defect regeneration after dental surgeries largely determines their final success. Collagen membranes have been proposed for the healing of such defects, but in some cases, they do not guarantee a sufficient volume of the regenerated tissue and vascularization. For this pu...
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| Veröffentlicht in: | International journal of molecular sciences 2023-12, Vol.24 (24), p.17330 |
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| creator | Antoshin, Artem Gostev, Mikhail Khristidis, Yana Giliazova, Aliia Voloshin, Sergei Blagushina, Nataliia Smirnova, Olga Diachkova, Ekaterina Istranova, Elena Usanova, Anna Solodov, Nikolai Fayzullin, Alexey Ivanova, Elena Sadchikova, Elena Vergara Bashkatova, Milena Noelia Drakina, Olga Tarasenko, Svetlana Timashev, Peter |
| description | The quality of soft tissue defect regeneration after dental surgeries largely determines their final success. Collagen membranes have been proposed for the healing of such defects, but in some cases, they do not guarantee a sufficient volume of the regenerated tissue and vascularization. For this purpose, lactoferrin, a protein with natural pro-regenerative, anti-inflammatory, and pro-angiogenic activity, can be added to collagen. In this article, we used a semipermeable barrier-assisted electrophoretic deposition (SBA-EPD) method for the production of collagen-lactoferrin membranes. The membrane structure was studied by SEM, and its mechanical properties were shown. The lactoferrin release kinetics were shown by ELISA within 75 h. When tested in vitro, we demonstrated that the collagen-lactoferrin membranes significantly increased the proliferation of keratinocytes (HaCaT) and fibroblasts (977hTERT) compared to blank collagen membranes. In vivo, on the vestibuloplasty and free gingival graft harvesting models, we showed that collagen-lactoferrin membranes decreased the wound inflammation and increased the healing rates and regeneration quality. In some parameters, collagen-lactoferrin membranes outperformed not only blank collagen membranes, but also the commercial membrane Mucograft
. Thus, we proved that collagen-lactoferrin membranes produced by the SBA-EPD method may be a valuable alternative to commercially used membranes for soft tissue regeneration in the oral cavity. |
| doi_str_mv | 10.3390/ijms242417330 |
| format | Article |
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Thus, we proved that collagen-lactoferrin membranes produced by the SBA-EPD method may be a valuable alternative to commercially used membranes for soft tissue regeneration in the oral cavity.</description><subject>Biocompatibility</subject><subject>Biodegradation</subject><subject>Cell growth</subject><subject>Collagen</subject><subject>Collagen - chemistry</subject><subject>Connective tissue</subject><subject>Edema</subject><subject>Fibroblasts</subject><subject>Lactoferrin</subject><subject>Membranes</subject><subject>Membranes, Artificial</subject><subject>Metabolism</subject><subject>Tissue engineering</subject><subject>Wound Healing</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0U1v1DAQBmALUdF24ci1isSll4A_E_tYLVuKtKhVKefIa49Zr5I4tR1Qf0P_NF61QNuTP_RoNDMvQu8J_siYwp_8bkiUU05axvArdEQ4pTXGTfv6yf0QHae0w5gyKtQbdMgkYYoIdYTuVz2YHMO0DRGyN7rv76plqD_DFJLPYMuj7_VPGOu1Njk4iNGP1TcYNlGPkKrfPm-r1bjVoyn4Kob6GoqGqLP_BfuPCWL2RboQq8uo--p7cLm68SnNUP3HYXyLDpzuE7x7PBfox_nqZnlRry-_fF2erWvDSJNrLqSljWZWyo1sHVaCW8mYMIaZDQMtHEjcilYQbFrjwCpjnbINE9pyIzlboNOHulMMtzOk3A0-GShjjhDm1FGFhaBEcVXohxd0F-Y4lu72ijdCsrL3BaoflIkhpQium6IfdLzrCO72KXXPUir-5LHqvBnA_tN_Y2F_ADZ3kDE</recordid><startdate>20231210</startdate><enddate>20231210</enddate><creator>Antoshin, Artem</creator><creator>Gostev, Mikhail</creator><creator>Khristidis, Yana</creator><creator>Giliazova, Aliia</creator><creator>Voloshin, Sergei</creator><creator>Blagushina, Nataliia</creator><creator>Smirnova, Olga</creator><creator>Diachkova, Ekaterina</creator><creator>Istranova, Elena</creator><creator>Usanova, Anna</creator><creator>Solodov, Nikolai</creator><creator>Fayzullin, Alexey</creator><creator>Ivanova, Elena</creator><creator>Sadchikova, Elena</creator><creator>Vergara Bashkatova, Milena Noelia</creator><creator>Drakina, Olga</creator><creator>Tarasenko, Svetlana</creator><creator>Timashev, Peter</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5601-0465</orcidid><orcidid>https://orcid.org/0000-0003-0575-0321</orcidid><orcidid>https://orcid.org/0000-0003-1065-0448</orcidid><orcidid>https://orcid.org/0000-0003-4388-8911</orcidid><orcidid>https://orcid.org/0009-0005-1695-2238</orcidid><orcidid>https://orcid.org/0000-0003-4137-8993</orcidid></search><sort><creationdate>20231210</creationdate><title>Electrophoretically Co-Deposited Collagen-Lactoferrin Membranes with Enhanced Pro-Regenerative Properties for Oral Soft Tissue Regeneration</title><author>Antoshin, Artem ; Gostev, Mikhail ; Khristidis, Yana ; Giliazova, Aliia ; Voloshin, Sergei ; Blagushina, Nataliia ; Smirnova, Olga ; Diachkova, Ekaterina ; Istranova, Elena ; Usanova, Anna ; Solodov, Nikolai ; Fayzullin, Alexey ; Ivanova, Elena ; Sadchikova, Elena ; Vergara Bashkatova, Milena Noelia ; Drakina, Olga ; Tarasenko, Svetlana ; Timashev, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-458d26a3d88b87f0954d8335cc3cb3ea5fe80757510c7cfed9cdf9d635ad4c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biocompatibility</topic><topic>Biodegradation</topic><topic>Cell growth</topic><topic>Collagen</topic><topic>Collagen - 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Collagen membranes have been proposed for the healing of such defects, but in some cases, they do not guarantee a sufficient volume of the regenerated tissue and vascularization. For this purpose, lactoferrin, a protein with natural pro-regenerative, anti-inflammatory, and pro-angiogenic activity, can be added to collagen. In this article, we used a semipermeable barrier-assisted electrophoretic deposition (SBA-EPD) method for the production of collagen-lactoferrin membranes. The membrane structure was studied by SEM, and its mechanical properties were shown. The lactoferrin release kinetics were shown by ELISA within 75 h. When tested in vitro, we demonstrated that the collagen-lactoferrin membranes significantly increased the proliferation of keratinocytes (HaCaT) and fibroblasts (977hTERT) compared to blank collagen membranes. In vivo, on the vestibuloplasty and free gingival graft harvesting models, we showed that collagen-lactoferrin membranes decreased the wound inflammation and increased the healing rates and regeneration quality. In some parameters, collagen-lactoferrin membranes outperformed not only blank collagen membranes, but also the commercial membrane Mucograft
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| subjects | Biocompatibility Biodegradation Cell growth Collagen Collagen - chemistry Connective tissue Edema Fibroblasts Lactoferrin Membranes Membranes, Artificial Metabolism Tissue engineering Wound Healing |
| title | Electrophoretically Co-Deposited Collagen-Lactoferrin Membranes with Enhanced Pro-Regenerative Properties for Oral Soft Tissue Regeneration |
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