CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?

Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle arrest by inhibiting the activity of cyclin-dependent kinases (CDKs). Over the years, extensive research has shed light...

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Veröffentlicht in:	International journal of molecular sciences 2023-12, Vol.24 (24), p.17488
Hauptverfasser:	Manousakis, Evangelos, Miralles, Clàudia Martinez, Esquerda, Maria Guimerà, Wright, Roni H G
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Binding sites Biomarkers Breast cancer Breast Neoplasms - metabolism Cancer therapies Cell cycle Cell Cycle - genetics Cell Cycle Proteins - metabolism Cell growth Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinases Cyclin-Dependent Kinases - metabolism Female Gene expression Humans Kinases Localization Metastasis Mutation Patients Phosphorylation Proteins Tumors
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