The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review
Purpose Prader–Willi syndrome is a serious genetic condition, capable of causing endocrinological imbalance, which has as one of its main treatments the growth hormone therapy. However, this therapy still causes some uncertainty concerning its effects on the respiratory parameters of those patients,...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2024-05, Vol.281 (5), p.2235-2242 |
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| container_title | European archives of oto-rhino-laryngology |
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| creator | Francisco, Gabriel Rossi Simões, Júlia Leão Batista de Carvalho Braga, Geórgia Guerra, Paulo Henrique Bagatini, Margarete Dulce |
| description | Purpose
Prader–Willi syndrome is a serious genetic condition, capable of causing endocrinological imbalance, which has as one of its main treatments the growth hormone therapy. However, this therapy still causes some uncertainty concerning its effects on the respiratory parameters of those patients, especially in cases of obstructive sleep apnea, therefore, presenting a need for the analysis of the relationship between the therapy and the otolaryngologic condition.
Methods
A systematic review following the PRISMA model was developed, with searches for keywords made in the databases PubMed (MEDLINE), Scopus, and Web of Science and registration in the PROSPERO platform (CRD42023404250).
Results
Three randomized controlled trials were considered eligible for inclusion in the review. None of the studies demonstrated statistically significant modifications in the obstructive sleep apnea parameters of Prader–Willi patients related to the growth hormone administration.
Conclusions
Growth hormone therapy is safe for Prader–Willi syndrome patients when analyzing their obstructive sleep apnea parameters. |
| doi_str_mv | 10.1007/s00405-023-08406-x |
| format | Article |
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Prader–Willi syndrome is a serious genetic condition, capable of causing endocrinological imbalance, which has as one of its main treatments the growth hormone therapy. However, this therapy still causes some uncertainty concerning its effects on the respiratory parameters of those patients, especially in cases of obstructive sleep apnea, therefore, presenting a need for the analysis of the relationship between the therapy and the otolaryngologic condition.
Methods
A systematic review following the PRISMA model was developed, with searches for keywords made in the databases PubMed (MEDLINE), Scopus, and Web of Science and registration in the PROSPERO platform (CRD42023404250).
Results
Three randomized controlled trials were considered eligible for inclusion in the review. None of the studies demonstrated statistically significant modifications in the obstructive sleep apnea parameters of Prader–Willi patients related to the growth hormone administration.
Conclusions
Growth hormone therapy is safe for Prader–Willi syndrome patients when analyzing their obstructive sleep apnea parameters.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-023-08406-x</identifier><identifier>PMID: 38133808</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Head and Neck Surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology ; Review Article</subject><ispartof>European archives of oto-rhino-laryngology, 2024-05, Vol.281 (5), p.2235-2242</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-1eb5dab572ccf5a12cf568fc2cc6af61ebedfefe460a773d6bc33617776875323</citedby><cites>FETCH-LOGICAL-c347t-1eb5dab572ccf5a12cf568fc2cc6af61ebedfefe460a773d6bc33617776875323</cites><orcidid>0000-0003-0384-9934 ; 0000-0003-4239-0716 ; 0000-0001-9263-4980 ; 0000-0002-1652-9692 ; 0000-0003-0109-5534</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-023-08406-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-023-08406-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38133808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Francisco, Gabriel Rossi</creatorcontrib><creatorcontrib>Simões, Júlia Leão Batista</creatorcontrib><creatorcontrib>de Carvalho Braga, Geórgia</creatorcontrib><creatorcontrib>Guerra, Paulo Henrique</creatorcontrib><creatorcontrib>Bagatini, Margarete Dulce</creatorcontrib><title>The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
Prader–Willi syndrome is a serious genetic condition, capable of causing endocrinological imbalance, which has as one of its main treatments the growth hormone therapy. However, this therapy still causes some uncertainty concerning its effects on the respiratory parameters of those patients, especially in cases of obstructive sleep apnea, therefore, presenting a need for the analysis of the relationship between the therapy and the otolaryngologic condition.
Methods
A systematic review following the PRISMA model was developed, with searches for keywords made in the databases PubMed (MEDLINE), Scopus, and Web of Science and registration in the PROSPERO platform (CRD42023404250).
Results
Three randomized controlled trials were considered eligible for inclusion in the review. None of the studies demonstrated statistically significant modifications in the obstructive sleep apnea parameters of Prader–Willi patients related to the growth hormone administration.
Conclusions
Growth hormone therapy is safe for Prader–Willi syndrome patients when analyzing their obstructive sleep apnea parameters.</description><subject>Head and Neck Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Review Article</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kbtOHDEUhq2IKCwkL5Aickkz4fg-S4dQbhJSUhCltDyeM-ygmfHE9gDbpU3NG-ZJ8LIkZRpfzvnOJ9k_IW8ZvGcA5jQBSFAVcFFBLUFX9y_IikkhK2m4PiArWAtTSWnMITlK6QYAlFyLV-RQ1EyIGuoV-X21QRqW7MOIiYaOXsdwlzd0E-IYJqR5g9HNW9pPuyMNTcpx8bm_RZoGxJm6eUJHZxfdiBnjk-NbdC3GP78efvTD0NO0ndpY_IXKPU45nVFXiinjWAqeRrzt8e41edm5IeGb5_2YfP_44eric3X59dOXi_PLygtpcsWwUa1rlOHed8oxXlZdd75ctet0aWPbYYdSgzNGtLrxQmhmjNG1UYKLY3Ky984x_FwwZTv2yeMwuAnDkixfg1KccbVD-R71MaQUsbNz7EcXt5aB3UVg9xHYEoF9isDel6F3z_6lGbH9N_L3zwsg9kAqrekao70JS5zKm_-nfQT4cZcv</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Francisco, Gabriel Rossi</creator><creator>Simões, Júlia Leão Batista</creator><creator>de Carvalho Braga, Geórgia</creator><creator>Guerra, Paulo Henrique</creator><creator>Bagatini, Margarete Dulce</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0384-9934</orcidid><orcidid>https://orcid.org/0000-0003-4239-0716</orcidid><orcidid>https://orcid.org/0000-0001-9263-4980</orcidid><orcidid>https://orcid.org/0000-0002-1652-9692</orcidid><orcidid>https://orcid.org/0000-0003-0109-5534</orcidid></search><sort><creationdate>20240501</creationdate><title>The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review</title><author>Francisco, Gabriel Rossi ; Simões, Júlia Leão Batista ; de Carvalho Braga, Geórgia ; Guerra, Paulo Henrique ; Bagatini, Margarete Dulce</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-1eb5dab572ccf5a12cf568fc2cc6af61ebedfefe460a773d6bc33617776875323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Head and Neck Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Francisco, Gabriel Rossi</creatorcontrib><creatorcontrib>Simões, Júlia Leão Batista</creatorcontrib><creatorcontrib>de Carvalho Braga, Geórgia</creatorcontrib><creatorcontrib>Guerra, Paulo Henrique</creatorcontrib><creatorcontrib>Bagatini, Margarete Dulce</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Francisco, Gabriel Rossi</au><au>Simões, Júlia Leão Batista</au><au>de Carvalho Braga, Geórgia</au><au>Guerra, Paulo Henrique</au><au>Bagatini, Margarete Dulce</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>281</volume><issue>5</issue><spage>2235</spage><epage>2242</epage><pages>2235-2242</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
Prader–Willi syndrome is a serious genetic condition, capable of causing endocrinological imbalance, which has as one of its main treatments the growth hormone therapy. However, this therapy still causes some uncertainty concerning its effects on the respiratory parameters of those patients, especially in cases of obstructive sleep apnea, therefore, presenting a need for the analysis of the relationship between the therapy and the otolaryngologic condition.
Methods
A systematic review following the PRISMA model was developed, with searches for keywords made in the databases PubMed (MEDLINE), Scopus, and Web of Science and registration in the PROSPERO platform (CRD42023404250).
Results
Three randomized controlled trials were considered eligible for inclusion in the review. None of the studies demonstrated statistically significant modifications in the obstructive sleep apnea parameters of Prader–Willi patients related to the growth hormone administration.
Conclusions
Growth hormone therapy is safe for Prader–Willi syndrome patients when analyzing their obstructive sleep apnea parameters.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38133808</pmid><doi>10.1007/s00405-023-08406-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0384-9934</orcidid><orcidid>https://orcid.org/0000-0003-4239-0716</orcidid><orcidid>https://orcid.org/0000-0001-9263-4980</orcidid><orcidid>https://orcid.org/0000-0002-1652-9692</orcidid><orcidid>https://orcid.org/0000-0003-0109-5534</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Head and Neck Surgery Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Review Article |
| title | The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review |
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