Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis
Objective We aimed to investigate the muscle coordination differences between a control group and patients with mild and severe knee osteoarthritis (KOA) using muscle synergy analysis and determine whether muscle coordination was associated with symptoms of KOA. Method Fifty-three women with medial...
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| Veröffentlicht in: | Clinical rheumatology 2024-02, Vol.43 (2), p.743-752 |
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| creator | Taniguchi, Masashi Umehara, Jun Yamagata, Momoko Yagi, Masahide Motomura, Yoshiki Okada, Sayaka Okada, Shogo Nakazato, Kaede Fukumoto, Yoshihiro Kobayashi, Masashi Kanemitsu, Kyoseki Ichihashi, Noriaki |
| description | Objective
We aimed to investigate the muscle coordination differences between a control group and patients with mild and severe knee osteoarthritis (KOA) using muscle synergy analysis and determine whether muscle coordination was associated with symptoms of KOA.
Method
Fifty-three women with medial KOA and 19 control patients participated in the study. The gait analyses and muscle activity measurements of seven lower limb muscles were assessed using a motion capture system and electromyography. Gait speed and knee adduction moment impulse were calculated. The spatiotemporal components of muscle synergy were extracted using non-negative matrix factorization, and the dynamic motor control index during walking (walk-DMC) was computed. The number of muscle synergy and their spatiotemporal components were compared among the mild KOA, severe KOA, and control groups. Moreover, the association between KOA symptoms with walk-DMC and other gait parameters was evaluated using multi-linear regression analysis.
Results
The number of muscle synergies was lower in mild and severe KOA compared with those in the control group. In synergy 1, the weightings of biceps femoris and gluteus medius in severe KOA were higher than that in the control group. In synergy 3, the weightings of higher tibial anterior and lower gastrocnemius lateralis were confirmed in the mild KOA group. Regression analysis showed that the walk-DMC was independently associated with knee-related symptoms of KOA after adjusting for the covariates.
Conclusions
Muscle coordination was altered in patients with KOA. The correlation between muscle coordination and KOA may be attributed to the knee-related symptoms.
Key points
• Patients with knee osteoarthritis (OA) experienced a deterioration in muscle coordination when walking.
• Loss of muscle coordination was associated with severe knee-related symptoms in knee OA.
• Considering muscle coordination as a knee OA symptom-related factor may provide improved treatment. |
| doi_str_mv | 10.1007/s10067-023-06852-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2905521226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153604760</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-8de583ee07b3741b2eb26edb9e280d78fe70439fa13a52031320ba07235b7e893</originalsourceid><addsrcrecordid>eNqFkc9u1DAQhy1ERZe2L8ABWeLCJXRsJ3F8RFX5I1XiQs-Rk8xuXTZ28Dha7Tvw0DjNAhIHuNjyzPebkfUx9krAOwGgrymftS5AqgLqppLF4RnbiFKVhTGlec42oDUUSpjmnL0kegQA2Rjxgp2rRiiljdqwH_d-wEjJ-sH5HR9n6vfI-xBiftvkgufDHJfWzrrEO0s48Fw8gXT0GHdHnuPcJeKWKPRuzR1cesjAOKUwEneeT7mOPlNPnW8ekQdKGGxMD9ElR5fsbGv3hFen-4Ldf7j9evOpuPvy8fPN-7uiLyuZimbAqlGIoDulS9FJ7GSNQ2dQNjDoZosaSmW2VihbSVBCSegsaKmqTmNj1AV7u86dYvg-I6V2dNTjfm89hplaJSpVQ6lr-C8qDVSVFFLWGX3zF_oY5ujzRzK1IFKVy265Un0MRBG37RTdaOOxFdAuWttVa5u1tk9a20MOvT6NnrsRh9-RXx4zoFaApkUWxj-7_zH2J3ucsFs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2921222349</pqid></control><display><type>article</type><title>Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis</title><source>Springer Nature - Complete Springer Journals</source><creator>Taniguchi, Masashi ; Umehara, Jun ; Yamagata, Momoko ; Yagi, Masahide ; Motomura, Yoshiki ; Okada, Sayaka ; Okada, Shogo ; Nakazato, Kaede ; Fukumoto, Yoshihiro ; Kobayashi, Masashi ; Kanemitsu, Kyoseki ; Ichihashi, Noriaki</creator><creatorcontrib>Taniguchi, Masashi ; Umehara, Jun ; Yamagata, Momoko ; Yagi, Masahide ; Motomura, Yoshiki ; Okada, Sayaka ; Okada, Shogo ; Nakazato, Kaede ; Fukumoto, Yoshihiro ; Kobayashi, Masashi ; Kanemitsu, Kyoseki ; Ichihashi, Noriaki</creatorcontrib><description>Objective
We aimed to investigate the muscle coordination differences between a control group and patients with mild and severe knee osteoarthritis (KOA) using muscle synergy analysis and determine whether muscle coordination was associated with symptoms of KOA.
Method
Fifty-three women with medial KOA and 19 control patients participated in the study. The gait analyses and muscle activity measurements of seven lower limb muscles were assessed using a motion capture system and electromyography. Gait speed and knee adduction moment impulse were calculated. The spatiotemporal components of muscle synergy were extracted using non-negative matrix factorization, and the dynamic motor control index during walking (walk-DMC) was computed. The number of muscle synergy and their spatiotemporal components were compared among the mild KOA, severe KOA, and control groups. Moreover, the association between KOA symptoms with walk-DMC and other gait parameters was evaluated using multi-linear regression analysis.
Results
The number of muscle synergies was lower in mild and severe KOA compared with those in the control group. In synergy 1, the weightings of biceps femoris and gluteus medius in severe KOA were higher than that in the control group. In synergy 3, the weightings of higher tibial anterior and lower gastrocnemius lateralis were confirmed in the mild KOA group. Regression analysis showed that the walk-DMC was independently associated with knee-related symptoms of KOA after adjusting for the covariates.
Conclusions
Muscle coordination was altered in patients with KOA. The correlation between muscle coordination and KOA may be attributed to the knee-related symptoms.
Key points
• Patients with knee osteoarthritis (OA) experienced a deterioration in muscle coordination when walking.
• Loss of muscle coordination was associated with severe knee-related symptoms in knee OA.
• Considering muscle coordination as a knee OA symptom-related factor may provide improved treatment.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-023-06852-w</identifier><identifier>PMID: 38133793</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>algorithms ; Arthritis ; Coordination ; Electromyography ; Gait ; Knee ; Medicine ; Medicine & Public Health ; Motor task performance ; Muscles ; Original Article ; Osteoarthritis ; Regression analysis ; Rheumatology ; tibia ; Walking</subject><ispartof>Clinical rheumatology, 2024-02, Vol.43 (2), p.743-752</ispartof><rights>The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-8de583ee07b3741b2eb26edb9e280d78fe70439fa13a52031320ba07235b7e893</citedby><cites>FETCH-LOGICAL-c452t-8de583ee07b3741b2eb26edb9e280d78fe70439fa13a52031320ba07235b7e893</cites><orcidid>0000-0002-1825-3570 ; 0000-0001-5401-9581 ; 0000-0002-6544-0678 ; 0000-0003-0516-770X ; 0000-0003-2508-2172 ; 0000-0002-7956-5017 ; 0000-0003-0548-0210 ; 0000-0002-9126-9843 ; 0000-0002-1258-0714 ; 0000-0002-6743-9021 ; 0000-0001-8192-5651</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-023-06852-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-023-06852-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38133793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taniguchi, Masashi</creatorcontrib><creatorcontrib>Umehara, Jun</creatorcontrib><creatorcontrib>Yamagata, Momoko</creatorcontrib><creatorcontrib>Yagi, Masahide</creatorcontrib><creatorcontrib>Motomura, Yoshiki</creatorcontrib><creatorcontrib>Okada, Sayaka</creatorcontrib><creatorcontrib>Okada, Shogo</creatorcontrib><creatorcontrib>Nakazato, Kaede</creatorcontrib><creatorcontrib>Fukumoto, Yoshihiro</creatorcontrib><creatorcontrib>Kobayashi, Masashi</creatorcontrib><creatorcontrib>Kanemitsu, Kyoseki</creatorcontrib><creatorcontrib>Ichihashi, Noriaki</creatorcontrib><title>Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objective
We aimed to investigate the muscle coordination differences between a control group and patients with mild and severe knee osteoarthritis (KOA) using muscle synergy analysis and determine whether muscle coordination was associated with symptoms of KOA.
Method
Fifty-three women with medial KOA and 19 control patients participated in the study. The gait analyses and muscle activity measurements of seven lower limb muscles were assessed using a motion capture system and electromyography. Gait speed and knee adduction moment impulse were calculated. The spatiotemporal components of muscle synergy were extracted using non-negative matrix factorization, and the dynamic motor control index during walking (walk-DMC) was computed. The number of muscle synergy and their spatiotemporal components were compared among the mild KOA, severe KOA, and control groups. Moreover, the association between KOA symptoms with walk-DMC and other gait parameters was evaluated using multi-linear regression analysis.
Results
The number of muscle synergies was lower in mild and severe KOA compared with those in the control group. In synergy 1, the weightings of biceps femoris and gluteus medius in severe KOA were higher than that in the control group. In synergy 3, the weightings of higher tibial anterior and lower gastrocnemius lateralis were confirmed in the mild KOA group. Regression analysis showed that the walk-DMC was independently associated with knee-related symptoms of KOA after adjusting for the covariates.
Conclusions
Muscle coordination was altered in patients with KOA. The correlation between muscle coordination and KOA may be attributed to the knee-related symptoms.
Key points
• Patients with knee osteoarthritis (OA) experienced a deterioration in muscle coordination when walking.
• Loss of muscle coordination was associated with severe knee-related symptoms in knee OA.
• Considering muscle coordination as a knee OA symptom-related factor may provide improved treatment.</description><subject>algorithms</subject><subject>Arthritis</subject><subject>Coordination</subject><subject>Electromyography</subject><subject>Gait</subject><subject>Knee</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Motor task performance</subject><subject>Muscles</subject><subject>Original Article</subject><subject>Osteoarthritis</subject><subject>Regression analysis</subject><subject>Rheumatology</subject><subject>tibia</subject><subject>Walking</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQhy1ERZe2L8ABWeLCJXRsJ3F8RFX5I1XiQs-Rk8xuXTZ28Dha7Tvw0DjNAhIHuNjyzPebkfUx9krAOwGgrymftS5AqgLqppLF4RnbiFKVhTGlec42oDUUSpjmnL0kegQA2Rjxgp2rRiiljdqwH_d-wEjJ-sH5HR9n6vfI-xBiftvkgufDHJfWzrrEO0s48Fw8gXT0GHdHnuPcJeKWKPRuzR1cesjAOKUwEneeT7mOPlNPnW8ekQdKGGxMD9ElR5fsbGv3hFen-4Ldf7j9evOpuPvy8fPN-7uiLyuZimbAqlGIoDulS9FJ7GSNQ2dQNjDoZosaSmW2VihbSVBCSegsaKmqTmNj1AV7u86dYvg-I6V2dNTjfm89hplaJSpVQ6lr-C8qDVSVFFLWGX3zF_oY5ujzRzK1IFKVy265Un0MRBG37RTdaOOxFdAuWttVa5u1tk9a20MOvT6NnrsRh9-RXx4zoFaApkUWxj-7_zH2J3ucsFs</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Taniguchi, Masashi</creator><creator>Umehara, Jun</creator><creator>Yamagata, Momoko</creator><creator>Yagi, Masahide</creator><creator>Motomura, Yoshiki</creator><creator>Okada, Sayaka</creator><creator>Okada, Shogo</creator><creator>Nakazato, Kaede</creator><creator>Fukumoto, Yoshihiro</creator><creator>Kobayashi, Masashi</creator><creator>Kanemitsu, Kyoseki</creator><creator>Ichihashi, Noriaki</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-1825-3570</orcidid><orcidid>https://orcid.org/0000-0001-5401-9581</orcidid><orcidid>https://orcid.org/0000-0002-6544-0678</orcidid><orcidid>https://orcid.org/0000-0003-0516-770X</orcidid><orcidid>https://orcid.org/0000-0003-2508-2172</orcidid><orcidid>https://orcid.org/0000-0002-7956-5017</orcidid><orcidid>https://orcid.org/0000-0003-0548-0210</orcidid><orcidid>https://orcid.org/0000-0002-9126-9843</orcidid><orcidid>https://orcid.org/0000-0002-1258-0714</orcidid><orcidid>https://orcid.org/0000-0002-6743-9021</orcidid><orcidid>https://orcid.org/0000-0001-8192-5651</orcidid></search><sort><creationdate>20240201</creationdate><title>Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis</title><author>Taniguchi, Masashi ; Umehara, Jun ; Yamagata, Momoko ; Yagi, Masahide ; Motomura, Yoshiki ; Okada, Sayaka ; Okada, Shogo ; Nakazato, Kaede ; Fukumoto, Yoshihiro ; Kobayashi, Masashi ; Kanemitsu, Kyoseki ; Ichihashi, Noriaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-8de583ee07b3741b2eb26edb9e280d78fe70439fa13a52031320ba07235b7e893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>algorithms</topic><topic>Arthritis</topic><topic>Coordination</topic><topic>Electromyography</topic><topic>Gait</topic><topic>Knee</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Motor task performance</topic><topic>Muscles</topic><topic>Original Article</topic><topic>Osteoarthritis</topic><topic>Regression analysis</topic><topic>Rheumatology</topic><topic>tibia</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taniguchi, Masashi</creatorcontrib><creatorcontrib>Umehara, Jun</creatorcontrib><creatorcontrib>Yamagata, Momoko</creatorcontrib><creatorcontrib>Yagi, Masahide</creatorcontrib><creatorcontrib>Motomura, Yoshiki</creatorcontrib><creatorcontrib>Okada, Sayaka</creatorcontrib><creatorcontrib>Okada, Shogo</creatorcontrib><creatorcontrib>Nakazato, Kaede</creatorcontrib><creatorcontrib>Fukumoto, Yoshihiro</creatorcontrib><creatorcontrib>Kobayashi, Masashi</creatorcontrib><creatorcontrib>Kanemitsu, Kyoseki</creatorcontrib><creatorcontrib>Ichihashi, Noriaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taniguchi, Masashi</au><au>Umehara, Jun</au><au>Yamagata, Momoko</au><au>Yagi, Masahide</au><au>Motomura, Yoshiki</au><au>Okada, Sayaka</au><au>Okada, Shogo</au><au>Nakazato, Kaede</au><au>Fukumoto, Yoshihiro</au><au>Kobayashi, Masashi</au><au>Kanemitsu, Kyoseki</au><au>Ichihashi, Noriaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>43</volume><issue>2</issue><spage>743</spage><epage>752</epage><pages>743-752</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Objective
We aimed to investigate the muscle coordination differences between a control group and patients with mild and severe knee osteoarthritis (KOA) using muscle synergy analysis and determine whether muscle coordination was associated with symptoms of KOA.
Method
Fifty-three women with medial KOA and 19 control patients participated in the study. The gait analyses and muscle activity measurements of seven lower limb muscles were assessed using a motion capture system and electromyography. Gait speed and knee adduction moment impulse were calculated. The spatiotemporal components of muscle synergy were extracted using non-negative matrix factorization, and the dynamic motor control index during walking (walk-DMC) was computed. The number of muscle synergy and their spatiotemporal components were compared among the mild KOA, severe KOA, and control groups. Moreover, the association between KOA symptoms with walk-DMC and other gait parameters was evaluated using multi-linear regression analysis.
Results
The number of muscle synergies was lower in mild and severe KOA compared with those in the control group. In synergy 1, the weightings of biceps femoris and gluteus medius in severe KOA were higher than that in the control group. In synergy 3, the weightings of higher tibial anterior and lower gastrocnemius lateralis were confirmed in the mild KOA group. Regression analysis showed that the walk-DMC was independently associated with knee-related symptoms of KOA after adjusting for the covariates.
Conclusions
Muscle coordination was altered in patients with KOA. The correlation between muscle coordination and KOA may be attributed to the knee-related symptoms.
Key points
• Patients with knee osteoarthritis (OA) experienced a deterioration in muscle coordination when walking.
• Loss of muscle coordination was associated with severe knee-related symptoms in knee OA.
• Considering muscle coordination as a knee OA symptom-related factor may provide improved treatment.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38133793</pmid><doi>10.1007/s10067-023-06852-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1825-3570</orcidid><orcidid>https://orcid.org/0000-0001-5401-9581</orcidid><orcidid>https://orcid.org/0000-0002-6544-0678</orcidid><orcidid>https://orcid.org/0000-0003-0516-770X</orcidid><orcidid>https://orcid.org/0000-0003-2508-2172</orcidid><orcidid>https://orcid.org/0000-0002-7956-5017</orcidid><orcidid>https://orcid.org/0000-0003-0548-0210</orcidid><orcidid>https://orcid.org/0000-0002-9126-9843</orcidid><orcidid>https://orcid.org/0000-0002-1258-0714</orcidid><orcidid>https://orcid.org/0000-0002-6743-9021</orcidid><orcidid>https://orcid.org/0000-0001-8192-5651</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical rheumatology, 2024-02, Vol.43 (2), p.743-752 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | algorithms Arthritis Coordination Electromyography Gait Knee Medicine Medicine & Public Health Motor task performance Muscles Original Article Osteoarthritis Regression analysis Rheumatology tibia Walking |
| title | Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis |
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