Detection of Germline Mutations in a Cohort of 250 Relatives of Mutation Carriers in Multigene Panel: Impact of Pathogenic Variants in Other Genes beyond BRCA1/2

Several hereditary-familial syndromes associated with various types of tumors have been identified to date, evidencing that hereditary cancers caused by germline mutations account for 5-10% of all tumors. Advances in genetic technology and the implementation of Next-Generation Sequencing (NGS) have...

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Veröffentlicht in:	Cancers 2023-12, Vol.15 (24), p.5730
Hauptverfasser:	Di Rado, Sara, Giansante, Roberta, Cicirelli, Michela, Pilenzi, Lucrezia, Dell'Elice, Anastasia, Anaclerio, Federico, Rimoldi, Martina, Grassadonia, Antonino, Grossi, Simona, Canale, Nicole, Ballerini, Patrizia, Stuppia, Liborio, Antonucci, Ivana
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 protein BRCA2 protein Breast cancer Cancer Colorectal cancer Genetic counseling Genetic testing Genomes Life sciences Medical prognosis Mutation Next-generation sequencing Ovarian cancer Surveillance Tumors
Online-Zugang:	Volltext
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