The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance
Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multipl...
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| Veröffentlicht in: | Cancers 2023-12, Vol.15 (24), p.5747 |
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| creator | Milković, Lidija Mlinarić, Monika Lučić, Ivan Čipak Gašparović, Ana |
| description | Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. These proteins are not directly responsible for MDR, but they support the survival of cancer cells under stress conditions. |
| doi_str_mv | 10.3390/cancers15245747 |
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The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Antimitotic agents Antineoplastic agents Antioxidants Aquaporins Breast cancer Cancer Cancer therapies Chemotherapy Detoxification Development and progression DNA binding proteins Drug resistance in microorganisms Enzymes Forkhead protein Glycerol Health aspects Hydrogen peroxide Immunotherapy Metastases Metastasis Multidrug resistance Oxidative stress Phenotypes Prevention Radiation therapy Signal transduction Transcription factors Tumors |
| title | The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance |
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