Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma

Lung cancer is the leading cause of cancer-related death worldwide. Discoidin domain receptor 1 (DDR1), a tyrosine kinase receptor, has been associated with poor prognosis in patients with non-small cell lung cancer (NSCLC). However, its role in tumorigenesis remains poorly understood. This work aim...

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Veröffentlicht in:	Cancers 2023-12, Vol.15 (24), p.5767
Hauptverfasser:	Maitz, Kathrin, Valadez-Cosmes, Paulina, Raftopoulou, Sofia, Kindler, Oliver, Kienzl, Melanie, Bolouri, Hamid, Houghton, A McGarry, Schicho, Rudolf, Heinemann, Akos, Kargl, Julia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antibodies Bacteria Cancer Cancer therapies Care and treatment CD4 antigen CD8 antigen Cells Cloning Collagen CRISPR Cytotoxicity Flow cytometry Foxp3 protein Gene expression Genomes Genomics Health aspects Homeostasis Immune system Immunoregulation Infiltration Kinases Leukocytes Lung cancer Lung transplantation Lymphocytes T Medical prognosis Metastases Non-small cell lung carcinoma p53 Protein Plasmids Prognosis Protein-tyrosine kinase receptors Proteins Small cell lung carcinoma T cells Therapeutic targets Tumor cells Tumor microenvironment Tumorigenesis Tumors
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