Plasma soluble suppression of tumorigenesis 2 measured in the emergency department for diagnosis and outcome prediction of sepsis: A single-center prospective study
[Display omitted] •sST2 is the decoy receptor for IL-33. Its concentration increases during sepsis.•sST2 had a lower AUC (0.76) than PCT but reclassified PCT-negative patients (NRI 29 %).•The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %.•sST2 was an...
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| Veröffentlicht in: | Clinica chimica acta 2024-01, Vol.553, p.117710-117710, Article 117710 |
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| creator | Battista, Stefania Bima, Paolo Forno, Daniela Luzzi, Demetrio Pizzolato, Elisa Ianniello, Alice Ponzetto, Federico Rumbolo, Francesca Settanni, Fabio Mengozzi, Giulio Morello, Fulvio Lupia, Enrico |
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•sST2 is the decoy receptor for IL-33. Its concentration increases during sepsis.•sST2 had a lower AUC (0.76) than PCT but reclassified PCT-negative patients (NRI 29 %).•The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %.•sST2 was an independent predictor of 30-day and 90-day all-cause mortality.
The diagnostic and prognostic performance of soluble Suppression of Tumorigenicity 2 (sST2) in suspected septic patients presenting to the Emergency Department (ED) is largely unknown.
Patients were included in this prospective study if there was high suspicion of sepsis. The plasma level of sST2 was measured during initial ED evaluation. Outcomes were the evaluation of (1) sST2 diagnostic performance (alone and in combination with procalcitonin [PCT]), and (2) sST2 ability to predict 30-day and 90-day all-cause mortality.
Among 569 patients included, 481 (84.5 %) had sepsis or septic shock. Plasma sST2 levels were more elevated in septic patients (159 [71–331] vs 50 [31–103] ng/mL, P |
| doi_str_mv | 10.1016/j.cca.2023.117710 |
| format | Article |
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•sST2 is the decoy receptor for IL-33. Its concentration increases during sepsis.•sST2 had a lower AUC (0.76) than PCT but reclassified PCT-negative patients (NRI 29 %).•The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %.•sST2 was an independent predictor of 30-day and 90-day all-cause mortality.
The diagnostic and prognostic performance of soluble Suppression of Tumorigenicity 2 (sST2) in suspected septic patients presenting to the Emergency Department (ED) is largely unknown.
Patients were included in this prospective study if there was high suspicion of sepsis. The plasma level of sST2 was measured during initial ED evaluation. Outcomes were the evaluation of (1) sST2 diagnostic performance (alone and in combination with procalcitonin [PCT]), and (2) sST2 ability to predict 30-day and 90-day all-cause mortality.
Among 569 patients included, 481 (84.5 %) had sepsis or septic shock. Plasma sST2 levels were more elevated in septic patients (159 [71–331] vs 50 [31–103] ng/mL, P < 0.001). The AUC of sST2 for sepsis diagnosis was lower than the AUC of PCT (0.76 vs 0.85, P = 0.03). The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %. sST2 was able to correctly reclassify septic patients with PCT <0.5 (NRI 28.9 % [P = 0.02]). sST2 level was an independent predictor of 30-day mortality in a model including clinical variables (aHR 2.03 [1.24–3.33], C-index 0.69).
sST2 could be a useful adjunct in diagnosing sepsis and in all-cause mortality prediction.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2023.117710</identifier><identifier>PMID: 38141937</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biomarkers ; Carcinogenesis ; Cell Transformation, Neoplastic ; Diagnosis ; Emergency department ; Emergency Service, Hospital ; Humans ; Interleukin-1 Receptor-Like 1 Protein ; Procalcitonin ; Prognosis ; Prospective Studies ; Sepsis ; Shock ; Shock, Septic - diagnosis ; sST2</subject><ispartof>Clinica chimica acta, 2024-01, Vol.553, p.117710-117710, Article 117710</ispartof><rights>2023 The Author(s)</rights><rights>Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c348t-80f4a4ae8914f3fcbc82431414bf19b84172b8701e6f8d6e8fc70deefaa449fe3</cites><orcidid>0000-0002-7833-9632 ; 0000-0003-2193-0509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2023.117710$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38141937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Battista, Stefania</creatorcontrib><creatorcontrib>Bima, Paolo</creatorcontrib><creatorcontrib>Forno, Daniela</creatorcontrib><creatorcontrib>Luzzi, Demetrio</creatorcontrib><creatorcontrib>Pizzolato, Elisa</creatorcontrib><creatorcontrib>Ianniello, Alice</creatorcontrib><creatorcontrib>Ponzetto, Federico</creatorcontrib><creatorcontrib>Rumbolo, Francesca</creatorcontrib><creatorcontrib>Settanni, Fabio</creatorcontrib><creatorcontrib>Mengozzi, Giulio</creatorcontrib><creatorcontrib>Morello, Fulvio</creatorcontrib><creatorcontrib>Lupia, Enrico</creatorcontrib><title>Plasma soluble suppression of tumorigenesis 2 measured in the emergency department for diagnosis and outcome prediction of sepsis: A single-center prospective study</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>[Display omitted]
•sST2 is the decoy receptor for IL-33. Its concentration increases during sepsis.•sST2 had a lower AUC (0.76) than PCT but reclassified PCT-negative patients (NRI 29 %).•The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %.•sST2 was an independent predictor of 30-day and 90-day all-cause mortality.
The diagnostic and prognostic performance of soluble Suppression of Tumorigenicity 2 (sST2) in suspected septic patients presenting to the Emergency Department (ED) is largely unknown.
Patients were included in this prospective study if there was high suspicion of sepsis. The plasma level of sST2 was measured during initial ED evaluation. Outcomes were the evaluation of (1) sST2 diagnostic performance (alone and in combination with procalcitonin [PCT]), and (2) sST2 ability to predict 30-day and 90-day all-cause mortality.
Among 569 patients included, 481 (84.5 %) had sepsis or septic shock. Plasma sST2 levels were more elevated in septic patients (159 [71–331] vs 50 [31–103] ng/mL, P < 0.001). The AUC of sST2 for sepsis diagnosis was lower than the AUC of PCT (0.76 vs 0.85, P = 0.03). The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %. sST2 was able to correctly reclassify septic patients with PCT <0.5 (NRI 28.9 % [P = 0.02]). sST2 level was an independent predictor of 30-day mortality in a model including clinical variables (aHR 2.03 [1.24–3.33], C-index 0.69).
sST2 could be a useful adjunct in diagnosing sepsis and in all-cause mortality prediction.</description><subject>Biomarkers</subject><subject>Carcinogenesis</subject><subject>Cell Transformation, Neoplastic</subject><subject>Diagnosis</subject><subject>Emergency department</subject><subject>Emergency Service, Hospital</subject><subject>Humans</subject><subject>Interleukin-1 Receptor-Like 1 Protein</subject><subject>Procalcitonin</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Sepsis</subject><subject>Shock</subject><subject>Shock, Septic - diagnosis</subject><subject>sST2</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O1DAQhC0EYoeFB-CCfOSSwZ14Jw6cViv-pJXgAGfLsduDR0kc3MlK8z486PZoBo6crJa_KnVXCfEa1BYU7N4dtt67ba3qZgvQtqCeiA2Ytqka3dVPxUYp1VWmM3AlXhAdeNRqB8_FVWNAQ9e0G_Hn--BodJLysPYDSlrnuSBRypPMUS7rmEva44SUSNZyREdrwSDTJJdfKHHEwr_-KAPOriwjTouMuciQ3H7KJ5Gbgszr4vOIkq1D8svFnHBm4L28lZSm_YCVZzUWpjLNyNgD77Os4fhSPItuIHx1ea_Fz08ff9x9qe6_ff56d3tf-UabpTIqaqcdmg50bKLvval1w5fqPkLXGw1t3ZtWAe6iCTs00bcqIEbntO4iNtfi7dmXN_i9Ii12TORxGNyEeSVbd-rmBtodAKNwRj0vSwWjnUsaXTlaUPZUjj1YLseeyrHncljz5mK_9iOGf4q_bTDw4QwgH_mQsFjyidPl0ArnYUNO_7F_BG57o-8</recordid><startdate>20240115</startdate><enddate>20240115</enddate><creator>Battista, Stefania</creator><creator>Bima, Paolo</creator><creator>Forno, Daniela</creator><creator>Luzzi, Demetrio</creator><creator>Pizzolato, Elisa</creator><creator>Ianniello, Alice</creator><creator>Ponzetto, Federico</creator><creator>Rumbolo, Francesca</creator><creator>Settanni, Fabio</creator><creator>Mengozzi, Giulio</creator><creator>Morello, Fulvio</creator><creator>Lupia, Enrico</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7833-9632</orcidid><orcidid>https://orcid.org/0000-0003-2193-0509</orcidid></search><sort><creationdate>20240115</creationdate><title>Plasma soluble suppression of tumorigenesis 2 measured in the emergency department for diagnosis and outcome prediction of sepsis: A single-center prospective study</title><author>Battista, Stefania ; Bima, Paolo ; Forno, Daniela ; Luzzi, Demetrio ; Pizzolato, Elisa ; Ianniello, Alice ; Ponzetto, Federico ; Rumbolo, Francesca ; Settanni, Fabio ; Mengozzi, Giulio ; Morello, Fulvio ; Lupia, Enrico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-80f4a4ae8914f3fcbc82431414bf19b84172b8701e6f8d6e8fc70deefaa449fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomarkers</topic><topic>Carcinogenesis</topic><topic>Cell Transformation, Neoplastic</topic><topic>Diagnosis</topic><topic>Emergency department</topic><topic>Emergency Service, Hospital</topic><topic>Humans</topic><topic>Interleukin-1 Receptor-Like 1 Protein</topic><topic>Procalcitonin</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Sepsis</topic><topic>Shock</topic><topic>Shock, Septic - diagnosis</topic><topic>sST2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Battista, Stefania</creatorcontrib><creatorcontrib>Bima, Paolo</creatorcontrib><creatorcontrib>Forno, Daniela</creatorcontrib><creatorcontrib>Luzzi, Demetrio</creatorcontrib><creatorcontrib>Pizzolato, Elisa</creatorcontrib><creatorcontrib>Ianniello, Alice</creatorcontrib><creatorcontrib>Ponzetto, Federico</creatorcontrib><creatorcontrib>Rumbolo, Francesca</creatorcontrib><creatorcontrib>Settanni, Fabio</creatorcontrib><creatorcontrib>Mengozzi, Giulio</creatorcontrib><creatorcontrib>Morello, Fulvio</creatorcontrib><creatorcontrib>Lupia, Enrico</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Battista, Stefania</au><au>Bima, Paolo</au><au>Forno, Daniela</au><au>Luzzi, Demetrio</au><au>Pizzolato, Elisa</au><au>Ianniello, Alice</au><au>Ponzetto, Federico</au><au>Rumbolo, Francesca</au><au>Settanni, Fabio</au><au>Mengozzi, Giulio</au><au>Morello, Fulvio</au><au>Lupia, Enrico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma soluble suppression of tumorigenesis 2 measured in the emergency department for diagnosis and outcome prediction of sepsis: A single-center prospective study</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2024-01-15</date><risdate>2024</risdate><volume>553</volume><spage>117710</spage><epage>117710</epage><pages>117710-117710</pages><artnum>117710</artnum><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>[Display omitted]
•sST2 is the decoy receptor for IL-33. Its concentration increases during sepsis.•sST2 had a lower AUC (0.76) than PCT but reclassified PCT-negative patients (NRI 29 %).•The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %.•sST2 was an independent predictor of 30-day and 90-day all-cause mortality.
The diagnostic and prognostic performance of soluble Suppression of Tumorigenicity 2 (sST2) in suspected septic patients presenting to the Emergency Department (ED) is largely unknown.
Patients were included in this prospective study if there was high suspicion of sepsis. The plasma level of sST2 was measured during initial ED evaluation. Outcomes were the evaluation of (1) sST2 diagnostic performance (alone and in combination with procalcitonin [PCT]), and (2) sST2 ability to predict 30-day and 90-day all-cause mortality.
Among 569 patients included, 481 (84.5 %) had sepsis or septic shock. Plasma sST2 levels were more elevated in septic patients (159 [71–331] vs 50 [31–103] ng/mL, P < 0.001). The AUC of sST2 for sepsis diagnosis was lower than the AUC of PCT (0.76 vs 0.85, P = 0.03). The best cut-off for sST2 was 61.7 ng/mL, with a sensitivity of 79.9 % and a specificity of 70.6 %. sST2 was able to correctly reclassify septic patients with PCT <0.5 (NRI 28.9 % [P = 0.02]). sST2 level was an independent predictor of 30-day mortality in a model including clinical variables (aHR 2.03 [1.24–3.33], C-index 0.69).
sST2 could be a useful adjunct in diagnosing sepsis and in all-cause mortality prediction.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38141937</pmid><doi>10.1016/j.cca.2023.117710</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7833-9632</orcidid><orcidid>https://orcid.org/0000-0003-2193-0509</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Carcinogenesis Cell Transformation, Neoplastic Diagnosis Emergency department Emergency Service, Hospital Humans Interleukin-1 Receptor-Like 1 Protein Procalcitonin Prognosis Prospective Studies Sepsis Shock Shock, Septic - diagnosis sST2 |
| title | Plasma soluble suppression of tumorigenesis 2 measured in the emergency department for diagnosis and outcome prediction of sepsis: A single-center prospective study |
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