Tackling Esophageal Squamous Cell Carcinoma with ITFn‐Pt(IV): A Novel Fusion of PD‐L1 Blockade, Chemotherapy, and T‐cell Activation

PD‐1/PD‐L1 blockade immunotherapy has gained approval for the treatment of a diverse range of tumors; however, its efficacy is constrained by the insufficient infiltration of T lymphocytes into the tumor microenvironment, resulting in suboptimal patient responses. Here, a pioneering immunotherapy fe...

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Veröffentlicht in:	Advanced healthcare materials 2024-04, Vol.13 (11), p.e2303623-n/a
Hauptverfasser:	Xin, Qi, Wang, Daji, Wang, Shenghui, Zhang, Lirong, Liang, Qian, Yan, Xiyun, Fan, Kelong, Jiang, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology B7-H1 Antigen - metabolism bioengineered ferritin nanocage Cell activation Cell death Cell Line, Tumor Cell proliferation Chemotherapy Dendritic cells Drug Delivery Systems - methods Effectiveness Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - drug therapy Esophageal Neoplasms - immunology Esophageal Neoplasms - pathology esophageal squamous cell carcinoma Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - immunology Esophageal Squamous Cell Carcinoma - pathology Esophageal Squamous Cell Carcinoma - therapy Ferritin Ferritins - chemistry Genetic engineering Humans immunogenic death Immunogenicity Immunotherapy Immunotherapy - methods Infiltration Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Malignancy Metastases Mice Nanobodies Nanoparticles - chemistry PD-L1 protein PD‐1/PD‐L1 blockade Squamous cell carcinoma T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor cells Tumor microenvironment Tumor Microenvironment - drug effects Tumors T‐cell activation
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