Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3

MST1, MST2, MST3, MST4, and YSK1 are conserved members of the mammalian sterile 20-like serine/threonine (MST) family that regulate cellular functions such as proliferation and migration. The MST3 isozyme plays a role in regulating cell growth and apoptosis, and its dysregulation has been linked to...

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Veröffentlicht in:Journal of medicinal chemistry 2024-01, Vol.67 (1), p.674-690
Hauptverfasser: Amrhein, Jennifer Alisa, Berger, Lena Marie, Balourdas, Dimitrios-Ilias, Joerger, Andreas C., Menge, Amelie, Krämer, Andreas, Frischkorn, Julia Marie, Berger, Benedict-Tilman, Elson, Lewis, Kaiser, Astrid, Schubert-Zsilavecz, Manfred, Müller, Susanne, Knapp, Stefan, Hanke, Thomas
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Sprache:eng
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