Breaking Osteoclast‐Acid Vicious Cycle to Rescue Osteoporosis via an Acid Responsive Organic Framework‐Based Neutralizing and Gene Editing Platform

In the osteoporotic microenvironment, the acidic microenvironment generated by excessive osteoclasts not only causes irreversible bone mineral dissolution, but also promotes reactive oxygen species (ROS) production to induce osteoblast senescence and excessive receptor activator of nuclear factor ka...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-05, Vol.20 (22), p.e2307595-n/a
Hauptverfasser:	Lin, Wenzheng, Hu, Sihan, Li, Ke, Shi, Yu, Pan, Chun, Xu, Zhuobin, Li, Dandan, Wang, Huihui, Li, Bin, Chen, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	acid neutralization Acids - chemistry Animals Biomedical materials CRISPR-Cas Systems Editing Female Gene Editing Genetic modification Metal-organic frameworks Metal-Organic Frameworks - chemistry metal–organic framework Mice Nanoparticles Nanoparticles - chemistry Neutralizing Osteoclasts - metabolism Osteogenesis - drug effects Osteoporosis Osteoporosis - metabolism Plasmids Plasmids - genetics RANK Ligand - metabolism Reactive Oxygen Species - metabolism receptor activator of nuclear factor kappa‐B ligand Sodium bicarbonate Sodium Bicarbonate - chemistry
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