rAAV-compatible human mini promoters enhance transgene expression in rat retinal ganglion cells

Recombinant adeno-associated viral vectors (rAAV) are the safest and most effective gene delivery platform to drive the treatment of many inherited eye disorders in well-characterized animal models. The use in rAAV of ubiquitous promoters derived from viral sequences such as CMV/CBA (chicken β-actin...

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Veröffentlicht in:	Experimental eye research 2024-02, Vol.239, p.109758-109758, Article 109758
Hauptverfasser:	Araujo, Victor G., Dias, Mariana S., Hauswirth, William W., Linden, Rafael, Petrs-Silva, Hilda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytomegalovirus Infections - genetics Cytomegalovirus Infections - metabolism Dependovirus - genetics Genetic Vectors Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Intravitreal injection Intravitreal Injections Mini-promoters rAAV Rats Retina Retina - metabolism retinal ganglion cell Retinal Ganglion Cells - metabolism Transduction, Genetic Transgenes
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