Evolving membrane-associated accessory protein variants for improved adeno-associated virus production

Manufacturing sufficient adeno-associated virus (AAV) to meet current and projected clinical needs is a significant hurdle to the growing gene therapy industry. The recently discovered membrane-associated accessory protein (MAAP) is encoded by an alternative open reading frame in the AAV cap gene th...

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Veröffentlicht in:	Molecular therapy 2024-02, Vol.32 (2), p.340-351
Hauptverfasser:	Schieferecke, Adam J., Lee, Hyuncheol, Chen, Aleysha, Kilaru, Vindhya, Krish Williams, Justin, Schaffer, David V.
Format:	Artikel
Sprache:	eng
Schlagworte:	AAV2 AAV6 AAV9 adeno-associated virus Capsid - metabolism Capsid Proteins - genetics Capsid Proteins - metabolism Dependovirus - metabolism directed evolution gene therapy Genetic Vectors - genetics MAAP manufacturing membrane-associated accessory protein Serogroup Transgenes
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