Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing

The 21kD GTPase Rac is an evolutionarily ancient regulator of cell shape and behavior. Rac2 is predominantly expressed in hematopoietic cells where it is essential for survival and motility. The hyperactivating mutation Rac2 also causes human immunodeficiency, although the mechanism remains unexplai...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-12, Vol.120 (52), p.e2310221120-e2310221120
Hauptverfasser:	Mishra, Abhinava K, Rodriguez, Melanie, Torres, Alba Yurani, Smith, Morgan, Rodriguez, Anthony, Bond, Annalise, Morrissey, Meghan A, Montell, Denise J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cancer Cancer immunotherapy Cannibalism Cell Death Cell size Chimeric antigen receptors Hematopoietic stem cells Humans Hypersensitivity Immunodeficiency Immunologic Deficiency Syndromes - genetics Immunotherapy Leukemia Lymphocytes Lymphocytes T Macrophages Macrophages - metabolism Mice Neoplasms rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein - metabolism Rac2 protein Receptors, Chimeric Antigen
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