HMGB1 in exosomes derived from gastric cancer cells induces M2‐like macrophage polarization by inhibiting the NF‐κB signaling pathway

Gastric cancer (GC) seriously threatens human health. High mobility group protein B1 (HMGB1) and M2‐like macrophages are closely associated with core events about human cancers, such as invasion, and metastasis, and cancer microenvironment. This study mainly determined the regulatory effect of HMGB1...

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Veröffentlicht in:	Cell biology international 2024-03, Vol.48 (3), p.334-346
Hauptverfasser:	Liu, Ke, Wang, Hui, Zhou, Jumei, Zhu, Suyu, Ma, Min, Xiao, Hua, Ding, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer immunotherapy Cell Line, Tumor Cell proliferation exosome Exosomes Exosomes - metabolism Gastric cancer High mobility group proteins HMGB1 HMGB1 protein HMGB1 Protein - metabolism Humans M2‐like macrophage Macrophages Macrophages - metabolism Metastases Microenvironments MicroRNAs - metabolism NF-kappa B - metabolism NF‐κB signaling pathway Polarization POU2F1 Signal Transduction Stomach Neoplasms - metabolism Tumor Microenvironment
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