Urine steroid metabolomics as a diagnostic tool in primary aldosteronism

Primary aldosteronism (PA) causes 5–10% of hypertension cases, but only a minority of patients are currently diagnosed and treated because of a complex, stepwise, and partly invasive workup. We tested the performance of urine steroid metabolomics, the computational analysis of 24-hour urine steroid...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2024-03, Vol.237, p.106445, Article 106445
Hauptverfasser:	Prete, Alessandro, Lang, Katharina, Pavlov, David, Rhayem, Yara, Sitch, Alice J., Franke, Anna S., Gilligan, Lorna C., Shackleton, Cedric H.L., Hahner, Stefanie, Quinkler, Marcus, Dekkers, Tanja, Deinum, Jaap, Reincke, Martin, Beuschlein, Felix, Biehl, Michael, Arlt, Wiebke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - diagnosis Adrenal Cortex Neoplasms - genetics Adrenocortical Adenoma - genetics Adult Aldosterone - metabolism Aldosterone-producing adenoma Bilateral primary aldosteronism G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism Humans Hybrid steroids Hyperaldosteronism - diagnosis Hyperaldosteronism - genetics Hyperaldosteronism - metabolism KCNJ5 Mass Spectrometry Mutation Primary aldosteronism Steroids Urine steroid metabolome
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