Exposures to drinking water disinfection byproducts and kidney function in Chinese women
Disinfection byproducts (DBPs), the ubiquitous contaminants in drinking water, have been shown to impair renal function in experimental studies. However, epidemiological evidence is sparse. To investigate exposures to DBPs in associations with renal function among women. A total of 920 women from De...
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| Veröffentlicht in: | Environmental research 2024-03, Vol.244, p.117925-117925, Article 117925 |
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| creator | Li, Cheng-Ru Deng, Yan-Ling Miao, Yu Zhang, Min Zeng, Jia-Yue Liu, Xiao-Ying Wu, Yang Li, Yang-Juan Liu, A-Xue Zhu, Jin-Qin Liu, Chong Zeng, Qiang |
| description | Disinfection byproducts (DBPs), the ubiquitous contaminants in drinking water, have been shown to impair renal function in experimental studies. However, epidemiological evidence is sparse.
To investigate exposures to DBPs in associations with renal function among women.
A total of 920 women from December 2018 to January 2020 were abstracted from the Tongji Reproductive and Environmental (TREE) Study, an ongoing cohort study in Wuhan, China. Urine samples were gathered at baseline recruitment and analyzed for dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) as biomarkers of DBP exposures. Serum uric acid (UA), creatinine, and estimated glomerular filtration rate (eGFR) were measured as indicators of renal function. Multivariate linear regression and restricted cubic spline (RCS) models were conducted to assess urinary DCAA and TCAA concentrations in associations with renal function indicators. Stratified analyses by age and body mass index (BMI) were also performed.
We found null evidence of urinary TCAA in associations with renal function indicators. However, elevated urinary DCAA tertiles were related to decreased eGFR (β = −1.78%, 95% CI: 3.21%, −0.36%, comparing the upper vs. lower tertile; P for trend = 0.01). This inverse association still existed when urinary DCAA concentration was treated as a continuous variable, and the dose-response relationship was linear based on the RCS model (P for overall association = 0.002 and P for non-linear associations = 0.44). In the stratified analyses, we found an association of urinary DCAA concentration with decreased UA level among women |
| doi_str_mv | 10.1016/j.envres.2023.117925 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2903326398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0013935123027299</els_id><sourcerecordid>2903326398</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-f63309f53d848af90e9dab6d6ad6e506a38f7bb718f189aeee70b8c00a25b5523</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78A5EcvXSddEzbXARZ1g8QvCh4C2kz0ay76Zq06v57K1WPnoZh3vedmYexYwFTAaI4W0wpvEdK0xxynApRqlxusYkAVWSgJG6zCYDATKEUe2w_pcXQComwy_awEoBliRP2NP9ct6kfcnjXcht9ePXhmX-YjiK3PvngqOl8G3i9WcfW9k2XuAmWv3obaMNdH8axD3z24gMl4h_tisIh23Fmmejopx6wx6v5w-wmu7u_vp1d3mUNCtFlrkAE5STa6rwyTgEpa-rCFsYWJKEwWLmyrktROVEpQ0Ql1FUDYHJZS5njATsdc4fr3npKnV751NByaQK1fdK5AsS8QFUN0vNR2sQ2pUhOr6NfmbjRAvQ3U73QI1P9zVSPTAfbyc-Gvl6R_TP9QhwEF6OAhj_fPUWdGk-hIevjAE_b1v-_4Qu9vItJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2903326398</pqid></control><display><type>article</type><title>Exposures to drinking water disinfection byproducts and kidney function in Chinese women</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Li, Cheng-Ru ; Deng, Yan-Ling ; Miao, Yu ; Zhang, Min ; Zeng, Jia-Yue ; Liu, Xiao-Ying ; Wu, Yang ; Li, Yang-Juan ; Liu, A-Xue ; Zhu, Jin-Qin ; Liu, Chong ; Zeng, Qiang</creator><creatorcontrib>Li, Cheng-Ru ; Deng, Yan-Ling ; Miao, Yu ; Zhang, Min ; Zeng, Jia-Yue ; Liu, Xiao-Ying ; Wu, Yang ; Li, Yang-Juan ; Liu, A-Xue ; Zhu, Jin-Qin ; Liu, Chong ; Zeng, Qiang</creatorcontrib><description>Disinfection byproducts (DBPs), the ubiquitous contaminants in drinking water, have been shown to impair renal function in experimental studies. However, epidemiological evidence is sparse.
To investigate exposures to DBPs in associations with renal function among women.
A total of 920 women from December 2018 to January 2020 were abstracted from the Tongji Reproductive and Environmental (TREE) Study, an ongoing cohort study in Wuhan, China. Urine samples were gathered at baseline recruitment and analyzed for dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) as biomarkers of DBP exposures. Serum uric acid (UA), creatinine, and estimated glomerular filtration rate (eGFR) were measured as indicators of renal function. Multivariate linear regression and restricted cubic spline (RCS) models were conducted to assess urinary DCAA and TCAA concentrations in associations with renal function indicators. Stratified analyses by age and body mass index (BMI) were also performed.
We found null evidence of urinary TCAA in associations with renal function indicators. However, elevated urinary DCAA tertiles were related to decreased eGFR (β = −1.78%, 95% CI: 3.21%, −0.36%, comparing the upper vs. lower tertile; P for trend = 0.01). This inverse association still existed when urinary DCAA concentration was treated as a continuous variable, and the dose-response relationship was linear based on the RCS model (P for overall association = 0.002 and P for non-linear associations = 0.44). In the stratified analyses, we found an association of urinary DCAA concentration with decreased UA level among women <30 years but an association with increased UA level among women ≥30 years (P for interaction = 0.04).
Urinary DCAA but not TCAA was associated with impaired renal function among women undergoing assisted reproductive technology.
[Display omitted]
•The associations between DBP exposures and renal function were firstly assessed.•Urinary TCAA was not associated with renal function indicators.•Urinary DCAA concentration was related to decreased eGFR level.•The association of urinary DCAA concentration with UA level was modified by age.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2023.117925</identifier><identifier>PMID: 38103773</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>China - epidemiology ; Cohort Studies ; Dichloroacetic acid ; Dichloroacetic Acid - urine ; Disinfection ; Disinfection byproducts ; Drinking Water ; Estimated glomerular filtration rate ; Female ; Humans ; Kidney ; Trichloroacetic acid ; Trichloroacetic Acid - urine ; Uric Acid</subject><ispartof>Environmental research, 2024-03, Vol.244, p.117925-117925, Article 117925</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-f63309f53d848af90e9dab6d6ad6e506a38f7bb718f189aeee70b8c00a25b5523</cites><orcidid>0000-0003-1439-404X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envres.2023.117925$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38103773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Cheng-Ru</creatorcontrib><creatorcontrib>Deng, Yan-Ling</creatorcontrib><creatorcontrib>Miao, Yu</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Zeng, Jia-Yue</creatorcontrib><creatorcontrib>Liu, Xiao-Ying</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Li, Yang-Juan</creatorcontrib><creatorcontrib>Liu, A-Xue</creatorcontrib><creatorcontrib>Zhu, Jin-Qin</creatorcontrib><creatorcontrib>Liu, Chong</creatorcontrib><creatorcontrib>Zeng, Qiang</creatorcontrib><title>Exposures to drinking water disinfection byproducts and kidney function in Chinese women</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Disinfection byproducts (DBPs), the ubiquitous contaminants in drinking water, have been shown to impair renal function in experimental studies. However, epidemiological evidence is sparse.
To investigate exposures to DBPs in associations with renal function among women.
A total of 920 women from December 2018 to January 2020 were abstracted from the Tongji Reproductive and Environmental (TREE) Study, an ongoing cohort study in Wuhan, China. Urine samples were gathered at baseline recruitment and analyzed for dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) as biomarkers of DBP exposures. Serum uric acid (UA), creatinine, and estimated glomerular filtration rate (eGFR) were measured as indicators of renal function. Multivariate linear regression and restricted cubic spline (RCS) models were conducted to assess urinary DCAA and TCAA concentrations in associations with renal function indicators. Stratified analyses by age and body mass index (BMI) were also performed.
We found null evidence of urinary TCAA in associations with renal function indicators. However, elevated urinary DCAA tertiles were related to decreased eGFR (β = −1.78%, 95% CI: 3.21%, −0.36%, comparing the upper vs. lower tertile; P for trend = 0.01). This inverse association still existed when urinary DCAA concentration was treated as a continuous variable, and the dose-response relationship was linear based on the RCS model (P for overall association = 0.002 and P for non-linear associations = 0.44). In the stratified analyses, we found an association of urinary DCAA concentration with decreased UA level among women <30 years but an association with increased UA level among women ≥30 years (P for interaction = 0.04).
Urinary DCAA but not TCAA was associated with impaired renal function among women undergoing assisted reproductive technology.
[Display omitted]
•The associations between DBP exposures and renal function were firstly assessed.•Urinary TCAA was not associated with renal function indicators.•Urinary DCAA concentration was related to decreased eGFR level.•The association of urinary DCAA concentration with UA level was modified by age.</description><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>Dichloroacetic acid</subject><subject>Dichloroacetic Acid - urine</subject><subject>Disinfection</subject><subject>Disinfection byproducts</subject><subject>Drinking Water</subject><subject>Estimated glomerular filtration rate</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney</subject><subject>Trichloroacetic acid</subject><subject>Trichloroacetic Acid - urine</subject><subject>Uric Acid</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A5EcvXSddEzbXARZ1g8QvCh4C2kz0ay76Zq06v57K1WPnoZh3vedmYexYwFTAaI4W0wpvEdK0xxynApRqlxusYkAVWSgJG6zCYDATKEUe2w_pcXQComwy_awEoBliRP2NP9ct6kfcnjXcht9ePXhmX-YjiK3PvngqOl8G3i9WcfW9k2XuAmWv3obaMNdH8axD3z24gMl4h_tisIh23Fmmejopx6wx6v5w-wmu7u_vp1d3mUNCtFlrkAE5STa6rwyTgEpa-rCFsYWJKEwWLmyrktROVEpQ0Ql1FUDYHJZS5njATsdc4fr3npKnV751NByaQK1fdK5AsS8QFUN0vNR2sQ2pUhOr6NfmbjRAvQ3U73QI1P9zVSPTAfbyc-Gvl6R_TP9QhwEF6OAhj_fPUWdGk-hIevjAE_b1v-_4Qu9vItJ</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Li, Cheng-Ru</creator><creator>Deng, Yan-Ling</creator><creator>Miao, Yu</creator><creator>Zhang, Min</creator><creator>Zeng, Jia-Yue</creator><creator>Liu, Xiao-Ying</creator><creator>Wu, Yang</creator><creator>Li, Yang-Juan</creator><creator>Liu, A-Xue</creator><creator>Zhu, Jin-Qin</creator><creator>Liu, Chong</creator><creator>Zeng, Qiang</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1439-404X</orcidid></search><sort><creationdate>20240301</creationdate><title>Exposures to drinking water disinfection byproducts and kidney function in Chinese women</title><author>Li, Cheng-Ru ; Deng, Yan-Ling ; Miao, Yu ; Zhang, Min ; Zeng, Jia-Yue ; Liu, Xiao-Ying ; Wu, Yang ; Li, Yang-Juan ; Liu, A-Xue ; Zhu, Jin-Qin ; Liu, Chong ; Zeng, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-f63309f53d848af90e9dab6d6ad6e506a38f7bb718f189aeee70b8c00a25b5523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>Dichloroacetic acid</topic><topic>Dichloroacetic Acid - urine</topic><topic>Disinfection</topic><topic>Disinfection byproducts</topic><topic>Drinking Water</topic><topic>Estimated glomerular filtration rate</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney</topic><topic>Trichloroacetic acid</topic><topic>Trichloroacetic Acid - urine</topic><topic>Uric Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Cheng-Ru</creatorcontrib><creatorcontrib>Deng, Yan-Ling</creatorcontrib><creatorcontrib>Miao, Yu</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Zeng, Jia-Yue</creatorcontrib><creatorcontrib>Liu, Xiao-Ying</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Li, Yang-Juan</creatorcontrib><creatorcontrib>Liu, A-Xue</creatorcontrib><creatorcontrib>Zhu, Jin-Qin</creatorcontrib><creatorcontrib>Liu, Chong</creatorcontrib><creatorcontrib>Zeng, Qiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Cheng-Ru</au><au>Deng, Yan-Ling</au><au>Miao, Yu</au><au>Zhang, Min</au><au>Zeng, Jia-Yue</au><au>Liu, Xiao-Ying</au><au>Wu, Yang</au><au>Li, Yang-Juan</au><au>Liu, A-Xue</au><au>Zhu, Jin-Qin</au><au>Liu, Chong</au><au>Zeng, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposures to drinking water disinfection byproducts and kidney function in Chinese women</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>244</volume><spage>117925</spage><epage>117925</epage><pages>117925-117925</pages><artnum>117925</artnum><issn>0013-9351</issn><eissn>1096-0953</eissn><abstract>Disinfection byproducts (DBPs), the ubiquitous contaminants in drinking water, have been shown to impair renal function in experimental studies. However, epidemiological evidence is sparse.
To investigate exposures to DBPs in associations with renal function among women.
A total of 920 women from December 2018 to January 2020 were abstracted from the Tongji Reproductive and Environmental (TREE) Study, an ongoing cohort study in Wuhan, China. Urine samples were gathered at baseline recruitment and analyzed for dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) as biomarkers of DBP exposures. Serum uric acid (UA), creatinine, and estimated glomerular filtration rate (eGFR) were measured as indicators of renal function. Multivariate linear regression and restricted cubic spline (RCS) models were conducted to assess urinary DCAA and TCAA concentrations in associations with renal function indicators. Stratified analyses by age and body mass index (BMI) were also performed.
We found null evidence of urinary TCAA in associations with renal function indicators. However, elevated urinary DCAA tertiles were related to decreased eGFR (β = −1.78%, 95% CI: 3.21%, −0.36%, comparing the upper vs. lower tertile; P for trend = 0.01). This inverse association still existed when urinary DCAA concentration was treated as a continuous variable, and the dose-response relationship was linear based on the RCS model (P for overall association = 0.002 and P for non-linear associations = 0.44). In the stratified analyses, we found an association of urinary DCAA concentration with decreased UA level among women <30 years but an association with increased UA level among women ≥30 years (P for interaction = 0.04).
Urinary DCAA but not TCAA was associated with impaired renal function among women undergoing assisted reproductive technology.
[Display omitted]
•The associations between DBP exposures and renal function were firstly assessed.•Urinary TCAA was not associated with renal function indicators.•Urinary DCAA concentration was related to decreased eGFR level.•The association of urinary DCAA concentration with UA level was modified by age.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>38103773</pmid><doi>10.1016/j.envres.2023.117925</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1439-404X</orcidid></addata></record> |
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| ispartof | Environmental research, 2024-03, Vol.244, p.117925-117925, Article 117925 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | China - epidemiology Cohort Studies Dichloroacetic acid Dichloroacetic Acid - urine Disinfection Disinfection byproducts Drinking Water Estimated glomerular filtration rate Female Humans Kidney Trichloroacetic acid Trichloroacetic Acid - urine Uric Acid |
| title | Exposures to drinking water disinfection byproducts and kidney function in Chinese women |
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