Antiviral therapy reduces hepatocellular carcinoma through suppressing hepatitis B virus replication may improve ER stress, mitochondrial and metabolic dysfunctions and decrease p62 in hybridized mice with single HBV transgene and miR‐122

Hepatitis B virus (HBV) hijacks autophagy for its replication. Nucleos(t)ide analogs (NUCs) treatment suppressed HBV replication and reduced hepatocellular carcinoma (HCC) incidence. However, the use of NUCs in chronic hepatitis B (CHB) patients with normal or minimally elevated serum alanine aminot...

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Veröffentlicht in:	Journal of medical virology 2023-12, Vol.95 (12), p.e29325-n/a
Hauptverfasser:	Liang, Yuh‐Jin, Chiou, Yu‐Wei, Chiu, Abby Pei‐Ting, Shiao, Ming‐Shi, Teng, Wei, Lin, Chin‐Wei, Cheng, Mei‐Ling, Huang, Yen‐Hua, Liang, Kung‐Hao, Su, Chien‐Wei, Lai, Chi‐Yu, Chen, Chih‐Li, Wu, Jaw‐Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 4 Alanine Alanine transaminase Animal models Animals Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Apoptosis Autophagy Carcinoma, Hepatocellular Cholesterol Cross-breeding Endoplasmic reticulum endoplasmic reticulum stress Fatty liver Fibrosis Free radicals Genomic instability Hepatitis Hepatitis B Hepatitis B virus Hepatitis B, Chronic - complications Hepatitis B, Chronic - drug therapy Hepatocellular carcinoma Humans Injury prevention Lipid metabolism Lipids Liver Liver cancer Liver Neoplasms metabolic dysregulation Metabolism Metabolomics Mice Mice, Transgenic MicroRNAs - genetics MicroRNAs - metabolism miRNA miR‐122 mitochondrial dysfunction Pathogenesis Replication Scavenging Steatosis Transgenes Transgenic mice Tricarboxylic acid cycle Tumor suppressor genes Virology Virus Replication Viruses
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