Factors Associated with Symptom Resolution after Aerobic Exercise Intervention in Adolescent and Young Adults with Concussion
Aerobic exercise facilitates postconcussion symptom resolution at the group level, but patient-level characteristics may affect the likelihood of treatment efficacy. This study aimed to investigate demographic and clinical characteristics, which differentiate postconcussion aerobic exercise treatmen...
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| Veröffentlicht in: | Medicine and science in sports and exercise 2024-05, Vol.56 (5), p.783-789 |
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| creator | Wingerson, Mathew J Hunt, Danielle L Wilson, Julie C Mannix, Rebekah C Meehan, William P Howell, David R |
| description | Aerobic exercise facilitates postconcussion symptom resolution at the group level, but patient-level characteristics may affect the likelihood of treatment efficacy.
This study aimed to investigate demographic and clinical characteristics, which differentiate postconcussion aerobic exercise treatment efficacy from nonefficacy in the intervention arm of a randomized clinical trial.
Adolescent and young adult participants initiated a standardized aerobic exercise intervention within 14 d of concussion, consisting of self-selected exercise for 100 min·wk -1 at an individualized heart rate (80% of heart rate induced symptom exacerbation during graded exercise testing). Treatment efficacy was defined as symptom resolution within 28-d postconcussion. Treatment efficacy and nonefficacy groups were compared on demographics, clinical characteristics, intervention adherence, and persistent symptom risk using the Predicting Persistent Postconcussive Problems in Pediatrics (5P) clinical risk score.
A total of 27 participants (16.1 ± 2.3 yr old; range, 11-21 yr; 52% female) began the intervention, with a mean of 9.5 ± 3.7 d after concussion; half ( n = 13; 48%) demonstrated treatment efficacy (symptom resolution within 28 d postconcussion). Those whose symptoms resolved within 28 d had significantly lower preintervention postconcussion symptom inventory scores (21.2 ± 13.2 vs 41.4 ± 22.2; P < 0.01), greater adherence to the intervention (77% vs 36%; P = 0.05), and longer average exercise duration (median [interquartile range], 49.7 [36.8-68.6] vs 30.4 [20.7-34.7] min; P < 0.01) than those whose symptoms lasted more than 28 d. Groups were similar in age, sex, timing of intervention, and preintervention 5P risk score.
A standardized aerobic exercise intervention initiated within 14 d of concussion demonstrated efficacy for approximately half of participants, according to our definition of treatment efficacy. This multisite aerobic exercise intervention suggests that lower symptom severity, higher intervention adherence, and greater exercise duration are factors that increase the likelihood of symptoms resolving within 28 d of concussion. |
| doi_str_mv | 10.1249/MSS.0000000000003358 |
| format | Article |
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This study aimed to investigate demographic and clinical characteristics, which differentiate postconcussion aerobic exercise treatment efficacy from nonefficacy in the intervention arm of a randomized clinical trial.
Adolescent and young adult participants initiated a standardized aerobic exercise intervention within 14 d of concussion, consisting of self-selected exercise for 100 min·wk -1 at an individualized heart rate (80% of heart rate induced symptom exacerbation during graded exercise testing). Treatment efficacy was defined as symptom resolution within 28-d postconcussion. Treatment efficacy and nonefficacy groups were compared on demographics, clinical characteristics, intervention adherence, and persistent symptom risk using the Predicting Persistent Postconcussive Problems in Pediatrics (5P) clinical risk score.
A total of 27 participants (16.1 ± 2.3 yr old; range, 11-21 yr; 52% female) began the intervention, with a mean of 9.5 ± 3.7 d after concussion; half ( n = 13; 48%) demonstrated treatment efficacy (symptom resolution within 28 d postconcussion). Those whose symptoms resolved within 28 d had significantly lower preintervention postconcussion symptom inventory scores (21.2 ± 13.2 vs 41.4 ± 22.2; P < 0.01), greater adherence to the intervention (77% vs 36%; P = 0.05), and longer average exercise duration (median [interquartile range], 49.7 [36.8-68.6] vs 30.4 [20.7-34.7] min; P < 0.01) than those whose symptoms lasted more than 28 d. Groups were similar in age, sex, timing of intervention, and preintervention 5P risk score.
A standardized aerobic exercise intervention initiated within 14 d of concussion demonstrated efficacy for approximately half of participants, according to our definition of treatment efficacy. This multisite aerobic exercise intervention suggests that lower symptom severity, higher intervention adherence, and greater exercise duration are factors that increase the likelihood of symptoms resolving within 28 d of concussion.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/MSS.0000000000003358</identifier><identifier>PMID: 38109187</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Athletic Injuries - diagnosis ; Brain Concussion - diagnosis ; Child ; Exercise - physiology ; Exercise Therapy ; Female ; Humans ; Male ; Post-Concussion Syndrome - therapy ; Risk Factors ; Treatment Outcome ; Young Adult</subject><ispartof>Medicine and science in sports and exercise, 2024-05, Vol.56 (5), p.783-789</ispartof><rights>Copyright © 2023 by the American College of Sports Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-d9eabf918c404bf0730ef3a074540b72f2fad589bc95d83c3f9263a25f455c783</citedby><cites>FETCH-LOGICAL-c307t-d9eabf918c404bf0730ef3a074540b72f2fad589bc95d83c3f9263a25f455c783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38109187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wingerson, Mathew J</creatorcontrib><creatorcontrib>Hunt, Danielle L</creatorcontrib><creatorcontrib>Wilson, Julie C</creatorcontrib><creatorcontrib>Mannix, Rebekah C</creatorcontrib><creatorcontrib>Meehan, William P</creatorcontrib><creatorcontrib>Howell, David R</creatorcontrib><title>Factors Associated with Symptom Resolution after Aerobic Exercise Intervention in Adolescent and Young Adults with Concussion</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>Aerobic exercise facilitates postconcussion symptom resolution at the group level, but patient-level characteristics may affect the likelihood of treatment efficacy.
This study aimed to investigate demographic and clinical characteristics, which differentiate postconcussion aerobic exercise treatment efficacy from nonefficacy in the intervention arm of a randomized clinical trial.
Adolescent and young adult participants initiated a standardized aerobic exercise intervention within 14 d of concussion, consisting of self-selected exercise for 100 min·wk -1 at an individualized heart rate (80% of heart rate induced symptom exacerbation during graded exercise testing). Treatment efficacy was defined as symptom resolution within 28-d postconcussion. Treatment efficacy and nonefficacy groups were compared on demographics, clinical characteristics, intervention adherence, and persistent symptom risk using the Predicting Persistent Postconcussive Problems in Pediatrics (5P) clinical risk score.
A total of 27 participants (16.1 ± 2.3 yr old; range, 11-21 yr; 52% female) began the intervention, with a mean of 9.5 ± 3.7 d after concussion; half ( n = 13; 48%) demonstrated treatment efficacy (symptom resolution within 28 d postconcussion). Those whose symptoms resolved within 28 d had significantly lower preintervention postconcussion symptom inventory scores (21.2 ± 13.2 vs 41.4 ± 22.2; P < 0.01), greater adherence to the intervention (77% vs 36%; P = 0.05), and longer average exercise duration (median [interquartile range], 49.7 [36.8-68.6] vs 30.4 [20.7-34.7] min; P < 0.01) than those whose symptoms lasted more than 28 d. Groups were similar in age, sex, timing of intervention, and preintervention 5P risk score.
A standardized aerobic exercise intervention initiated within 14 d of concussion demonstrated efficacy for approximately half of participants, according to our definition of treatment efficacy. This multisite aerobic exercise intervention suggests that lower symptom severity, higher intervention adherence, and greater exercise duration are factors that increase the likelihood of symptoms resolving within 28 d of concussion.</description><subject>Adolescent</subject><subject>Athletic Injuries - diagnosis</subject><subject>Brain Concussion - diagnosis</subject><subject>Child</subject><subject>Exercise - physiology</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Post-Concussion Syndrome - therapy</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEUhYMotlb_gUiWbqbm6UyWpVgtVASrC1dDJpNoZGZSk4zahf_daKuId3PhcM59fAAcYzTGhImz6-VyjP4UpbzYAUPMKcoQxXwXDBEWPBOY4gE4COE5mXJK8T4Y0AIjgYt8CD5mUkXnA5yE4JSVUdfwzcYnuFy3q-haeKuDa_poXQelidrDifausgpevGuvbNBw3iX5VXffHtvBSe0aHVQSoOxq-OD67jGJfRPDZvTUdaoPIdkPwZ6RTdBH2z4C97OLu-lVtri5nE8ni0xRlMesFlpWJh2sGGKVSV8gbahEOeMMVTkxxMiaF6JSgtcFVdQIck4l4YZxrvKCjsDpZu7Ku5deh1i2Nl3YNLLTrg8lEQkfYSSlRoBtrMq7ELw25crbVvp1iVH5Bb5M4Mv_4FPsZLuhr1pd_4Z-SNNPqgCATg</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Wingerson, Mathew J</creator><creator>Hunt, Danielle L</creator><creator>Wilson, Julie C</creator><creator>Mannix, Rebekah C</creator><creator>Meehan, William P</creator><creator>Howell, David R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240501</creationdate><title>Factors Associated with Symptom Resolution after Aerobic Exercise Intervention in Adolescent and Young Adults with Concussion</title><author>Wingerson, Mathew J ; Hunt, Danielle L ; Wilson, Julie C ; Mannix, Rebekah C ; Meehan, William P ; Howell, David R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-d9eabf918c404bf0730ef3a074540b72f2fad589bc95d83c3f9263a25f455c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Athletic Injuries - diagnosis</topic><topic>Brain Concussion - diagnosis</topic><topic>Child</topic><topic>Exercise - physiology</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Post-Concussion Syndrome - therapy</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wingerson, Mathew J</creatorcontrib><creatorcontrib>Hunt, Danielle L</creatorcontrib><creatorcontrib>Wilson, Julie C</creatorcontrib><creatorcontrib>Mannix, Rebekah C</creatorcontrib><creatorcontrib>Meehan, William P</creatorcontrib><creatorcontrib>Howell, David R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wingerson, Mathew J</au><au>Hunt, Danielle L</au><au>Wilson, Julie C</au><au>Mannix, Rebekah C</au><au>Meehan, William P</au><au>Howell, David R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Associated with Symptom Resolution after Aerobic Exercise Intervention in Adolescent and Young Adults with Concussion</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>56</volume><issue>5</issue><spage>783</spage><epage>789</epage><pages>783-789</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><abstract>Aerobic exercise facilitates postconcussion symptom resolution at the group level, but patient-level characteristics may affect the likelihood of treatment efficacy.
This study aimed to investigate demographic and clinical characteristics, which differentiate postconcussion aerobic exercise treatment efficacy from nonefficacy in the intervention arm of a randomized clinical trial.
Adolescent and young adult participants initiated a standardized aerobic exercise intervention within 14 d of concussion, consisting of self-selected exercise for 100 min·wk -1 at an individualized heart rate (80% of heart rate induced symptom exacerbation during graded exercise testing). Treatment efficacy was defined as symptom resolution within 28-d postconcussion. Treatment efficacy and nonefficacy groups were compared on demographics, clinical characteristics, intervention adherence, and persistent symptom risk using the Predicting Persistent Postconcussive Problems in Pediatrics (5P) clinical risk score.
A total of 27 participants (16.1 ± 2.3 yr old; range, 11-21 yr; 52% female) began the intervention, with a mean of 9.5 ± 3.7 d after concussion; half ( n = 13; 48%) demonstrated treatment efficacy (symptom resolution within 28 d postconcussion). Those whose symptoms resolved within 28 d had significantly lower preintervention postconcussion symptom inventory scores (21.2 ± 13.2 vs 41.4 ± 22.2; P < 0.01), greater adherence to the intervention (77% vs 36%; P = 0.05), and longer average exercise duration (median [interquartile range], 49.7 [36.8-68.6] vs 30.4 [20.7-34.7] min; P < 0.01) than those whose symptoms lasted more than 28 d. Groups were similar in age, sex, timing of intervention, and preintervention 5P risk score.
A standardized aerobic exercise intervention initiated within 14 d of concussion demonstrated efficacy for approximately half of participants, according to our definition of treatment efficacy. This multisite aerobic exercise intervention suggests that lower symptom severity, higher intervention adherence, and greater exercise duration are factors that increase the likelihood of symptoms resolving within 28 d of concussion.</abstract><cop>United States</cop><pmid>38109187</pmid><doi>10.1249/MSS.0000000000003358</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Athletic Injuries - diagnosis Brain Concussion - diagnosis Child Exercise - physiology Exercise Therapy Female Humans Male Post-Concussion Syndrome - therapy Risk Factors Treatment Outcome Young Adult |
| title | Factors Associated with Symptom Resolution after Aerobic Exercise Intervention in Adolescent and Young Adults with Concussion |
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