Impact of Medical and Neurologic Complications on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage in a Middle-Income Country

Almost two thirds of the world's aneurysmal subarachnoid hemorrhage (aSAH) are in low- and middle-income countries. Herein, we aimed to evaluate the impact of complications on the outcome of aSAH in a middle-income country. Baseline data (age, sex, World Federation of Neurosurgical Society, tim...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:World neurosurgery 2024-03, Vol.183, p.e250-e260
Hauptverfasser: Vasconcellos de Oliveira Souza, Natália, Rouanet, Carolina, Fontoura Solla, Davi Jorge, Barroso de Lima, Caio Vinícius, Trevizo, Juliana, Rezende, Flavio, Alves, Maramelia Miranda, de Oliveira Manuel, Airton Leonardo, Righy, Cassia, Chaddad Neto, Feres, Frudit, Michel, Silva, Gisele Sampaio
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page e260
container_issue
container_start_page e250
container_title World neurosurgery
container_volume 183
creator Vasconcellos de Oliveira Souza, Natália
Rouanet, Carolina
Fontoura Solla, Davi Jorge
Barroso de Lima, Caio Vinícius
Trevizo, Juliana
Rezende, Flavio
Alves, Maramelia Miranda
de Oliveira Manuel, Airton Leonardo
Righy, Cassia
Chaddad Neto, Feres
Frudit, Michel
Silva, Gisele Sampaio
description Almost two thirds of the world's aneurysmal subarachnoid hemorrhage (aSAH) are in low- and middle-income countries. Herein, we aimed to evaluate the impact of complications on the outcome of aSAH in a middle-income country. Baseline data (age, sex, World Federation of Neurosurgical Society, time ictus-treatment, treatment modality) and medical and neurologic complications from a cohort in Brazil (2016–2019) were evaluated: delayed cerebral ischemia; hydrocephalus; meningitis; seizures; intracranial hypertension; infections (pneumonia, bloodstream, urinary tract infection infection of undetermined source); sodium disturbances; acute kidney injury; and cardiac and pulmonary complications. The primary outcome was the modified Rankin scale (mRS) at hospital discharge. Univariate and multivariate models were employed. From 212 patients (71.7% female, age 52.7 ± 12.8), 92% developed at least 1 complication (any infection—43.9%, hydrocephalus—34.4%, intracranial hypertension—33%, infection of undetermined source—20.8%, hypernatremia—20.8%, hyponatremia—19.8%, delayed cerebral ischemia−related infarction—18.7%, pneumonia—18.4%, acute kidney injury—16.5%, and seizures—11.8%). In unadjusted analysis, all but hyponatremia and urinary tract infection were associated with mRS 3–6 at discharge; however, complications explained only 12% of the variation in functional outcome (mRS). Most patients were treated by clipping (66.5%), and 15.6% (33 patients) did not receive a definitive treatment. The median time ictus-admission and ictus-treatment were 5 and 9 days, respectively. While medical and neurologic complications are a recognized opportunity to improve aSAH care, low- and middle-income countries comprise 70% of the world population and still encounter difficulties concerning early definitive aneurysm treatment, rebleeding, and human and material resources.
doi_str_mv 10.1016/j.wneu.2023.12.068
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2903323913</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1878875023017916</els_id><sourcerecordid>2903323913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-2e2b9a57fff139c93061b0d42fff34b958c89f7f7d58c4a16c9a4e88662a28803</originalsourceid><addsrcrecordid>eNp9kc1O3DAUha2KqiDKC3RRedlNgn8yiS11g0a0jASlUtu15dg3jEeJPbUd0LwDD42HAZZ44yvfc46u74fQF0pqSmh7vqkfPMw1I4zXlNWkFR_QCRWdqETXyqO3ekGO0VlKG1IOp43o-Cd0zAUljeT8BD2upq02GYcB34B1Ro9Ye4t_wRzDGO6cwcswbcfSyC74hIPHeQ34ds4mTLC3_S4d8DnhB5fX-KIMFXdpKjl_5l5HbdY-OIuvYAoxrvUdYOexxjfO2hGqlX-OWYbZ57j7jD4Oekxw9nKfon8_Lv8ur6rr25-r5cV1ZTjpcsWA9VIvumEYKJdGctLSntiGlQfe9HIhjJBDN3S2VI2mrZG6ASHalmkmBOGn6NshdxvD_xlSVpNLBsZRewhzUkwSzhmXlBcpO0hNDClFGNQ2uknHnaJE7UGojdqDUHsQijJVQBTT15f8uZ_Avlle114E3w8CKL-8dxBVMmWJphCIYLKywb2X_wRjnptq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2903323913</pqid></control><display><type>article</type><title>Impact of Medical and Neurologic Complications on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage in a Middle-Income Country</title><source>Access via ScienceDirect (Elsevier)</source><creator>Vasconcellos de Oliveira Souza, Natália ; Rouanet, Carolina ; Fontoura Solla, Davi Jorge ; Barroso de Lima, Caio Vinícius ; Trevizo, Juliana ; Rezende, Flavio ; Alves, Maramelia Miranda ; de Oliveira Manuel, Airton Leonardo ; Righy, Cassia ; Chaddad Neto, Feres ; Frudit, Michel ; Silva, Gisele Sampaio</creator><creatorcontrib>Vasconcellos de Oliveira Souza, Natália ; Rouanet, Carolina ; Fontoura Solla, Davi Jorge ; Barroso de Lima, Caio Vinícius ; Trevizo, Juliana ; Rezende, Flavio ; Alves, Maramelia Miranda ; de Oliveira Manuel, Airton Leonardo ; Righy, Cassia ; Chaddad Neto, Feres ; Frudit, Michel ; Silva, Gisele Sampaio</creatorcontrib><description>Almost two thirds of the world's aneurysmal subarachnoid hemorrhage (aSAH) are in low- and middle-income countries. Herein, we aimed to evaluate the impact of complications on the outcome of aSAH in a middle-income country. Baseline data (age, sex, World Federation of Neurosurgical Society, time ictus-treatment, treatment modality) and medical and neurologic complications from a cohort in Brazil (2016–2019) were evaluated: delayed cerebral ischemia; hydrocephalus; meningitis; seizures; intracranial hypertension; infections (pneumonia, bloodstream, urinary tract infection infection of undetermined source); sodium disturbances; acute kidney injury; and cardiac and pulmonary complications. The primary outcome was the modified Rankin scale (mRS) at hospital discharge. Univariate and multivariate models were employed. From 212 patients (71.7% female, age 52.7 ± 12.8), 92% developed at least 1 complication (any infection—43.9%, hydrocephalus—34.4%, intracranial hypertension—33%, infection of undetermined source—20.8%, hypernatremia—20.8%, hyponatremia—19.8%, delayed cerebral ischemia−related infarction—18.7%, pneumonia—18.4%, acute kidney injury—16.5%, and seizures—11.8%). In unadjusted analysis, all but hyponatremia and urinary tract infection were associated with mRS 3–6 at discharge; however, complications explained only 12% of the variation in functional outcome (mRS). Most patients were treated by clipping (66.5%), and 15.6% (33 patients) did not receive a definitive treatment. The median time ictus-admission and ictus-treatment were 5 and 9 days, respectively. While medical and neurologic complications are a recognized opportunity to improve aSAH care, low- and middle-income countries comprise 70% of the world population and still encounter difficulties concerning early definitive aneurysm treatment, rebleeding, and human and material resources.</description><identifier>ISSN: 1878-8750</identifier><identifier>ISSN: 1878-8769</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2023.12.068</identifier><identifier>PMID: 38104933</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aneurysmal subarachnoid hemorrhage ; Delayed cerebral ischemia ; Medical complications ; Neurologic complications ; Poor-grade subarachnoid hemorrhage ; VASOGRADE</subject><ispartof>World neurosurgery, 2024-03, Vol.183, p.e250-e260</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-2e2b9a57fff139c93061b0d42fff34b958c89f7f7d58c4a16c9a4e88662a28803</cites><orcidid>0000-0002-5092-6595 ; 0000-0002-3247-3123 ; 0000-0002-9206-9552 ; 0000-0001-7874-7452 ; 0000-0002-1032-5787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.wneu.2023.12.068$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38104933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasconcellos de Oliveira Souza, Natália</creatorcontrib><creatorcontrib>Rouanet, Carolina</creatorcontrib><creatorcontrib>Fontoura Solla, Davi Jorge</creatorcontrib><creatorcontrib>Barroso de Lima, Caio Vinícius</creatorcontrib><creatorcontrib>Trevizo, Juliana</creatorcontrib><creatorcontrib>Rezende, Flavio</creatorcontrib><creatorcontrib>Alves, Maramelia Miranda</creatorcontrib><creatorcontrib>de Oliveira Manuel, Airton Leonardo</creatorcontrib><creatorcontrib>Righy, Cassia</creatorcontrib><creatorcontrib>Chaddad Neto, Feres</creatorcontrib><creatorcontrib>Frudit, Michel</creatorcontrib><creatorcontrib>Silva, Gisele Sampaio</creatorcontrib><title>Impact of Medical and Neurologic Complications on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage in a Middle-Income Country</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>Almost two thirds of the world's aneurysmal subarachnoid hemorrhage (aSAH) are in low- and middle-income countries. Herein, we aimed to evaluate the impact of complications on the outcome of aSAH in a middle-income country. Baseline data (age, sex, World Federation of Neurosurgical Society, time ictus-treatment, treatment modality) and medical and neurologic complications from a cohort in Brazil (2016–2019) were evaluated: delayed cerebral ischemia; hydrocephalus; meningitis; seizures; intracranial hypertension; infections (pneumonia, bloodstream, urinary tract infection infection of undetermined source); sodium disturbances; acute kidney injury; and cardiac and pulmonary complications. The primary outcome was the modified Rankin scale (mRS) at hospital discharge. Univariate and multivariate models were employed. From 212 patients (71.7% female, age 52.7 ± 12.8), 92% developed at least 1 complication (any infection—43.9%, hydrocephalus—34.4%, intracranial hypertension—33%, infection of undetermined source—20.8%, hypernatremia—20.8%, hyponatremia—19.8%, delayed cerebral ischemia−related infarction—18.7%, pneumonia—18.4%, acute kidney injury—16.5%, and seizures—11.8%). In unadjusted analysis, all but hyponatremia and urinary tract infection were associated with mRS 3–6 at discharge; however, complications explained only 12% of the variation in functional outcome (mRS). Most patients were treated by clipping (66.5%), and 15.6% (33 patients) did not receive a definitive treatment. The median time ictus-admission and ictus-treatment were 5 and 9 days, respectively. While medical and neurologic complications are a recognized opportunity to improve aSAH care, low- and middle-income countries comprise 70% of the world population and still encounter difficulties concerning early definitive aneurysm treatment, rebleeding, and human and material resources.</description><subject>Aneurysmal subarachnoid hemorrhage</subject><subject>Delayed cerebral ischemia</subject><subject>Medical complications</subject><subject>Neurologic complications</subject><subject>Poor-grade subarachnoid hemorrhage</subject><subject>VASOGRADE</subject><issn>1878-8750</issn><issn>1878-8769</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1O3DAUha2KqiDKC3RRedlNgn8yiS11g0a0jASlUtu15dg3jEeJPbUd0LwDD42HAZZ44yvfc46u74fQF0pqSmh7vqkfPMw1I4zXlNWkFR_QCRWdqETXyqO3ekGO0VlKG1IOp43o-Cd0zAUljeT8BD2upq02GYcB34B1Ro9Ye4t_wRzDGO6cwcswbcfSyC74hIPHeQ34ds4mTLC3_S4d8DnhB5fX-KIMFXdpKjl_5l5HbdY-OIuvYAoxrvUdYOexxjfO2hGqlX-OWYbZ57j7jD4Oekxw9nKfon8_Lv8ur6rr25-r5cV1ZTjpcsWA9VIvumEYKJdGctLSntiGlQfe9HIhjJBDN3S2VI2mrZG6ASHalmkmBOGn6NshdxvD_xlSVpNLBsZRewhzUkwSzhmXlBcpO0hNDClFGNQ2uknHnaJE7UGojdqDUHsQijJVQBTT15f8uZ_Avlle114E3w8CKL-8dxBVMmWJphCIYLKywb2X_wRjnptq</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Vasconcellos de Oliveira Souza, Natália</creator><creator>Rouanet, Carolina</creator><creator>Fontoura Solla, Davi Jorge</creator><creator>Barroso de Lima, Caio Vinícius</creator><creator>Trevizo, Juliana</creator><creator>Rezende, Flavio</creator><creator>Alves, Maramelia Miranda</creator><creator>de Oliveira Manuel, Airton Leonardo</creator><creator>Righy, Cassia</creator><creator>Chaddad Neto, Feres</creator><creator>Frudit, Michel</creator><creator>Silva, Gisele Sampaio</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5092-6595</orcidid><orcidid>https://orcid.org/0000-0002-3247-3123</orcidid><orcidid>https://orcid.org/0000-0002-9206-9552</orcidid><orcidid>https://orcid.org/0000-0001-7874-7452</orcidid><orcidid>https://orcid.org/0000-0002-1032-5787</orcidid></search><sort><creationdate>202403</creationdate><title>Impact of Medical and Neurologic Complications on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage in a Middle-Income Country</title><author>Vasconcellos de Oliveira Souza, Natália ; Rouanet, Carolina ; Fontoura Solla, Davi Jorge ; Barroso de Lima, Caio Vinícius ; Trevizo, Juliana ; Rezende, Flavio ; Alves, Maramelia Miranda ; de Oliveira Manuel, Airton Leonardo ; Righy, Cassia ; Chaddad Neto, Feres ; Frudit, Michel ; Silva, Gisele Sampaio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-2e2b9a57fff139c93061b0d42fff34b958c89f7f7d58c4a16c9a4e88662a28803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aneurysmal subarachnoid hemorrhage</topic><topic>Delayed cerebral ischemia</topic><topic>Medical complications</topic><topic>Neurologic complications</topic><topic>Poor-grade subarachnoid hemorrhage</topic><topic>VASOGRADE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasconcellos de Oliveira Souza, Natália</creatorcontrib><creatorcontrib>Rouanet, Carolina</creatorcontrib><creatorcontrib>Fontoura Solla, Davi Jorge</creatorcontrib><creatorcontrib>Barroso de Lima, Caio Vinícius</creatorcontrib><creatorcontrib>Trevizo, Juliana</creatorcontrib><creatorcontrib>Rezende, Flavio</creatorcontrib><creatorcontrib>Alves, Maramelia Miranda</creatorcontrib><creatorcontrib>de Oliveira Manuel, Airton Leonardo</creatorcontrib><creatorcontrib>Righy, Cassia</creatorcontrib><creatorcontrib>Chaddad Neto, Feres</creatorcontrib><creatorcontrib>Frudit, Michel</creatorcontrib><creatorcontrib>Silva, Gisele Sampaio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasconcellos de Oliveira Souza, Natália</au><au>Rouanet, Carolina</au><au>Fontoura Solla, Davi Jorge</au><au>Barroso de Lima, Caio Vinícius</au><au>Trevizo, Juliana</au><au>Rezende, Flavio</au><au>Alves, Maramelia Miranda</au><au>de Oliveira Manuel, Airton Leonardo</au><au>Righy, Cassia</au><au>Chaddad Neto, Feres</au><au>Frudit, Michel</au><au>Silva, Gisele Sampaio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Medical and Neurologic Complications on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage in a Middle-Income Country</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2024-03</date><risdate>2024</risdate><volume>183</volume><spage>e250</spage><epage>e260</epage><pages>e250-e260</pages><issn>1878-8750</issn><issn>1878-8769</issn><eissn>1878-8769</eissn><abstract>Almost two thirds of the world's aneurysmal subarachnoid hemorrhage (aSAH) are in low- and middle-income countries. Herein, we aimed to evaluate the impact of complications on the outcome of aSAH in a middle-income country. Baseline data (age, sex, World Federation of Neurosurgical Society, time ictus-treatment, treatment modality) and medical and neurologic complications from a cohort in Brazil (2016–2019) were evaluated: delayed cerebral ischemia; hydrocephalus; meningitis; seizures; intracranial hypertension; infections (pneumonia, bloodstream, urinary tract infection infection of undetermined source); sodium disturbances; acute kidney injury; and cardiac and pulmonary complications. The primary outcome was the modified Rankin scale (mRS) at hospital discharge. Univariate and multivariate models were employed. From 212 patients (71.7% female, age 52.7 ± 12.8), 92% developed at least 1 complication (any infection—43.9%, hydrocephalus—34.4%, intracranial hypertension—33%, infection of undetermined source—20.8%, hypernatremia—20.8%, hyponatremia—19.8%, delayed cerebral ischemia−related infarction—18.7%, pneumonia—18.4%, acute kidney injury—16.5%, and seizures—11.8%). In unadjusted analysis, all but hyponatremia and urinary tract infection were associated with mRS 3–6 at discharge; however, complications explained only 12% of the variation in functional outcome (mRS). Most patients were treated by clipping (66.5%), and 15.6% (33 patients) did not receive a definitive treatment. The median time ictus-admission and ictus-treatment were 5 and 9 days, respectively. While medical and neurologic complications are a recognized opportunity to improve aSAH care, low- and middle-income countries comprise 70% of the world population and still encounter difficulties concerning early definitive aneurysm treatment, rebleeding, and human and material resources.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38104933</pmid><doi>10.1016/j.wneu.2023.12.068</doi><orcidid>https://orcid.org/0000-0002-5092-6595</orcidid><orcidid>https://orcid.org/0000-0002-3247-3123</orcidid><orcidid>https://orcid.org/0000-0002-9206-9552</orcidid><orcidid>https://orcid.org/0000-0001-7874-7452</orcidid><orcidid>https://orcid.org/0000-0002-1032-5787</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1878-8750
ispartof World neurosurgery, 2024-03, Vol.183, p.e250-e260
issn 1878-8750
1878-8769
1878-8769
language eng
recordid cdi_proquest_miscellaneous_2903323913
source Access via ScienceDirect (Elsevier)
subjects Aneurysmal subarachnoid hemorrhage
Delayed cerebral ischemia
Medical complications
Neurologic complications
Poor-grade subarachnoid hemorrhage
VASOGRADE
title Impact of Medical and Neurologic Complications on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage in a Middle-Income Country
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T04%3A16%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Medical%20and%20Neurologic%20Complications%20on%20the%20Outcome%20of%20Patients%20with%20Aneurysmal%20Subarachnoid%20Hemorrhage%20in%20a%20Middle-Income%20Country&rft.jtitle=World%20neurosurgery&rft.au=Vasconcellos%20de%20Oliveira%20Souza,%20Nat%C3%A1lia&rft.date=2024-03&rft.volume=183&rft.spage=e250&rft.epage=e260&rft.pages=e250-e260&rft.issn=1878-8750&rft.eissn=1878-8769&rft_id=info:doi/10.1016/j.wneu.2023.12.068&rft_dat=%3Cproquest_cross%3E2903323913%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2903323913&rft_id=info:pmid/38104933&rft_els_id=S1878875023017916&rfr_iscdi=true