Obeticholic acid protects against lithocholic acid-induced exogenous cell apoptosis during cholestatic liver injury

Lithocholic acid (LCA)-induced cholestasis was accompanied by the occurrence of apoptosis, which indicated that anti-apoptosis was a therapeutic strategy for primary biliary cholangitis (PBC). As an agonist of (Farnesoid X receptor) FXR, we supposed that the hepatoprotection of Obeticholic acid (OCA...

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Veröffentlicht in:	Life sciences (1973) 2024-01, Vol.337, p.122355-122355, Article 122355
Hauptverfasser:	Lu, Qian, Zhu, Yangping, Wang, Changling, Zhang, Rongmi, Miao, Yingying, Chai, Yuanyuan, Jiang, Zhenzhou, Yu, Qinwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bile Acids and Salts - metabolism Cholestasis - chemically induced Cholestasis - complications Cholestasis - drug therapy Chromatography, Liquid Lithocholic Acid - adverse effects Liver - metabolism Mice Tandem Mass Spectrometry
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