The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis
Studies have shown an association between eosinophilia and clinical outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, contradictory findings exist. Our study aims to systematically evaluate the association between elevated peripheral blood eosinophils and cli...
Gespeichert in:
| Veröffentlicht in: | Respiratory medicine 2024-02, Vol.222, p.107501, Article 107501 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 107501 |
| container_title | Respiratory medicine |
| container_volume | 222 |
| creator | Liu, Hai Xie, Yongpeng Huang, Yuanyuan Luo, Kangle Gu, Yongli Zhang, Huan Xu, Yi Chen, Xuefeng |
| description | Studies have shown an association between eosinophilia and clinical outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, contradictory findings exist. Our study aims to systematically evaluate the association between elevated peripheral blood eosinophils and clinical outcome of patients with AECOPD.
An electronic search was conducted for relevant studies published from database inception to February 28, 2023, on PubMed, EMBASE, Cochrane Library, and Web of Science. The analysis covered studies on the correlation between EOS AECOPD and mortality, hospital stay duration, readmission and hospitalization rates, and invasive mechanical ventilation. Where applicable, relative risk (RR) and weighted mean difference (WMD) were extracted, pooled, and assessed using meta-analysis. Sensitivity analysis was performed to explore the source of heterogeneity.
Fifteen high-quality studies including 14 cohort studies and one case-control study were included in the meta-analysis. Compared with non-eosinophilic AECOPD patients, those with eosinophilic AECOPD had a lower risk of mortality (RR = 0.65, 95 % confidence interval [CI] 0.54, 0.77, P |
| doi_str_mv | 10.1016/j.rmed.2023.107501 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2903323697</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S095461112300389X</els_id><sourcerecordid>2903323697</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-466e08312323e75f96bd421659af43dd722079ee76487c1eb2f51c796e012c703</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi0EokvhD3BAPnLJ4q_YG8SlqviSKnEpZ8txJlqvnHjxOG33B_E_cbrtldNIM-_7jGZeQt5ztuWM60-HbZ5g2AomZG2YlvEXZMNbKRrJtHpJNqxrVaM55xfkDeKBMdYpxV6TC7njTJmd2ZC_t3ugDjH54EpIM-2h3APUGlMaKCQMczruQ0Tq5oH6GObgXaRpKT5NQNNInV8KUHhwHnL_CMG17fc5VS1NPZa8-BLugB6XOKXZ5RMdAoJD-EyvKJ6wwFSNnma4C3D_uGmC4ho3u3jCgG_Jq9FFhHdP9ZL8_vb19vpHc_Pr-8_rq5vGy1aXRmkNbCe5kEKCacdO94MSXLedG5UcBiMEMx2A0WpnPIdejC33pqsuLrxh8pJ8PHOPOf1ZAIudAnqI0c2QFrSiY7KydWeqVJylPifEDKM95jDV0yxndo3HHuwaj13jsed4qunDE3_p19mz5TmPKvhyFkC9sv4iW_QBZg9DyOCLHVL4H_8fLVSkLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2903323697</pqid></control><display><type>article</type><title>The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Liu, Hai ; Xie, Yongpeng ; Huang, Yuanyuan ; Luo, Kangle ; Gu, Yongli ; Zhang, Huan ; Xu, Yi ; Chen, Xuefeng</creator><creatorcontrib>Liu, Hai ; Xie, Yongpeng ; Huang, Yuanyuan ; Luo, Kangle ; Gu, Yongli ; Zhang, Huan ; Xu, Yi ; Chen, Xuefeng</creatorcontrib><description>Studies have shown an association between eosinophilia and clinical outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, contradictory findings exist. Our study aims to systematically evaluate the association between elevated peripheral blood eosinophils and clinical outcome of patients with AECOPD.
An electronic search was conducted for relevant studies published from database inception to February 28, 2023, on PubMed, EMBASE, Cochrane Library, and Web of Science. The analysis covered studies on the correlation between EOS AECOPD and mortality, hospital stay duration, readmission and hospitalization rates, and invasive mechanical ventilation. Where applicable, relative risk (RR) and weighted mean difference (WMD) were extracted, pooled, and assessed using meta-analysis. Sensitivity analysis was performed to explore the source of heterogeneity.
Fifteen high-quality studies including 14 cohort studies and one case-control study were included in the meta-analysis. Compared with non-eosinophilic AECOPD patients, those with eosinophilic AECOPD had a lower risk of mortality (RR = 0.65, 95 % confidence interval [CI] 0.54, 0.77, P < 0.001), shorter length of hospital stay (WMD = −1.56, 95%CI -2.16, −0.96, P < 0.001), and higher readmission rate (RR = 1.07, 95%CI 1.01,1.13, P = 0.029). No difference was found concerning the rate of hospitalization and invasive mechanical ventilation between the two groups.
Individuals diagnosed with eosinophilic AECOPD had a reduced mortality rate, a truncated period of hospitalization, and an insubstantial increase in the probability of readmission relative to their non-eosinophilic AECOPD counterparts. The level of eosinophils in blood has been shown to serve as a potential predictive biomarker for AECOPD patients.
•Eosinophilia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with improved outcomes, including lower mortality risk and shorter hospital stay.•Patients with eosinophilic AECOPD have higher readmission rates, highlighting the importance of post-discharge monitoring.•Peripheral blood eosinophil count could be a valuable biomarker for predicting prognosis and tailoring individualized treatment in AECOPD.•This systematic review and meta-analysis provide robust evidence supporting the role of eosinophils in AECOPD, aiding clinicians in understanding disease pathogenesis and optimizing patient management.</description><identifier>ISSN: 0954-6111</identifier><identifier>ISSN: 1532-3064</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2023.107501</identifier><identifier>PMID: 38104787</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Blood eosinophils ; Case-Control Studies ; Chronic obstructive pulmonary disease ; Disease Progression ; Eosinophils ; Hospitalization ; Humans ; Observational studies ; Pulmonary Disease, Chronic Obstructive - diagnosis</subject><ispartof>Respiratory medicine, 2024-02, Vol.222, p.107501, Article 107501</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-466e08312323e75f96bd421659af43dd722079ee76487c1eb2f51c796e012c703</citedby><cites>FETCH-LOGICAL-c356t-466e08312323e75f96bd421659af43dd722079ee76487c1eb2f51c796e012c703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S095461112300389X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38104787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Hai</creatorcontrib><creatorcontrib>Xie, Yongpeng</creatorcontrib><creatorcontrib>Huang, Yuanyuan</creatorcontrib><creatorcontrib>Luo, Kangle</creatorcontrib><creatorcontrib>Gu, Yongli</creatorcontrib><creatorcontrib>Zhang, Huan</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Chen, Xuefeng</creatorcontrib><title>The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Studies have shown an association between eosinophilia and clinical outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, contradictory findings exist. Our study aims to systematically evaluate the association between elevated peripheral blood eosinophils and clinical outcome of patients with AECOPD.
An electronic search was conducted for relevant studies published from database inception to February 28, 2023, on PubMed, EMBASE, Cochrane Library, and Web of Science. The analysis covered studies on the correlation between EOS AECOPD and mortality, hospital stay duration, readmission and hospitalization rates, and invasive mechanical ventilation. Where applicable, relative risk (RR) and weighted mean difference (WMD) were extracted, pooled, and assessed using meta-analysis. Sensitivity analysis was performed to explore the source of heterogeneity.
Fifteen high-quality studies including 14 cohort studies and one case-control study were included in the meta-analysis. Compared with non-eosinophilic AECOPD patients, those with eosinophilic AECOPD had a lower risk of mortality (RR = 0.65, 95 % confidence interval [CI] 0.54, 0.77, P < 0.001), shorter length of hospital stay (WMD = −1.56, 95%CI -2.16, −0.96, P < 0.001), and higher readmission rate (RR = 1.07, 95%CI 1.01,1.13, P = 0.029). No difference was found concerning the rate of hospitalization and invasive mechanical ventilation between the two groups.
Individuals diagnosed with eosinophilic AECOPD had a reduced mortality rate, a truncated period of hospitalization, and an insubstantial increase in the probability of readmission relative to their non-eosinophilic AECOPD counterparts. The level of eosinophils in blood has been shown to serve as a potential predictive biomarker for AECOPD patients.
•Eosinophilia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with improved outcomes, including lower mortality risk and shorter hospital stay.•Patients with eosinophilic AECOPD have higher readmission rates, highlighting the importance of post-discharge monitoring.•Peripheral blood eosinophil count could be a valuable biomarker for predicting prognosis and tailoring individualized treatment in AECOPD.•This systematic review and meta-analysis provide robust evidence supporting the role of eosinophils in AECOPD, aiding clinicians in understanding disease pathogenesis and optimizing patient management.</description><subject>Blood eosinophils</subject><subject>Case-Control Studies</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Disease Progression</subject><subject>Eosinophils</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Observational studies</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><issn>0954-6111</issn><issn>1532-3064</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EokvhD3BAPnLJ4q_YG8SlqviSKnEpZ8txJlqvnHjxOG33B_E_cbrtldNIM-_7jGZeQt5ztuWM60-HbZ5g2AomZG2YlvEXZMNbKRrJtHpJNqxrVaM55xfkDeKBMdYpxV6TC7njTJmd2ZC_t3ugDjH54EpIM-2h3APUGlMaKCQMczruQ0Tq5oH6GObgXaRpKT5NQNNInV8KUHhwHnL_CMG17fc5VS1NPZa8-BLugB6XOKXZ5RMdAoJD-EyvKJ6wwFSNnma4C3D_uGmC4ho3u3jCgG_Jq9FFhHdP9ZL8_vb19vpHc_Pr-8_rq5vGy1aXRmkNbCe5kEKCacdO94MSXLedG5UcBiMEMx2A0WpnPIdejC33pqsuLrxh8pJ8PHOPOf1ZAIudAnqI0c2QFrSiY7KydWeqVJylPifEDKM95jDV0yxndo3HHuwaj13jsed4qunDE3_p19mz5TmPKvhyFkC9sv4iW_QBZg9DyOCLHVL4H_8fLVSkLw</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Liu, Hai</creator><creator>Xie, Yongpeng</creator><creator>Huang, Yuanyuan</creator><creator>Luo, Kangle</creator><creator>Gu, Yongli</creator><creator>Zhang, Huan</creator><creator>Xu, Yi</creator><creator>Chen, Xuefeng</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202402</creationdate><title>The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis</title><author>Liu, Hai ; Xie, Yongpeng ; Huang, Yuanyuan ; Luo, Kangle ; Gu, Yongli ; Zhang, Huan ; Xu, Yi ; Chen, Xuefeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-466e08312323e75f96bd421659af43dd722079ee76487c1eb2f51c796e012c703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Blood eosinophils</topic><topic>Case-Control Studies</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Disease Progression</topic><topic>Eosinophils</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Observational studies</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Hai</creatorcontrib><creatorcontrib>Xie, Yongpeng</creatorcontrib><creatorcontrib>Huang, Yuanyuan</creatorcontrib><creatorcontrib>Luo, Kangle</creatorcontrib><creatorcontrib>Gu, Yongli</creatorcontrib><creatorcontrib>Zhang, Huan</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Chen, Xuefeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Hai</au><au>Xie, Yongpeng</au><au>Huang, Yuanyuan</au><au>Luo, Kangle</au><au>Gu, Yongli</au><au>Zhang, Huan</au><au>Xu, Yi</au><au>Chen, Xuefeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2024-02</date><risdate>2024</risdate><volume>222</volume><spage>107501</spage><pages>107501-</pages><artnum>107501</artnum><issn>0954-6111</issn><issn>1532-3064</issn><eissn>1532-3064</eissn><abstract>Studies have shown an association between eosinophilia and clinical outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, contradictory findings exist. Our study aims to systematically evaluate the association between elevated peripheral blood eosinophils and clinical outcome of patients with AECOPD.
An electronic search was conducted for relevant studies published from database inception to February 28, 2023, on PubMed, EMBASE, Cochrane Library, and Web of Science. The analysis covered studies on the correlation between EOS AECOPD and mortality, hospital stay duration, readmission and hospitalization rates, and invasive mechanical ventilation. Where applicable, relative risk (RR) and weighted mean difference (WMD) were extracted, pooled, and assessed using meta-analysis. Sensitivity analysis was performed to explore the source of heterogeneity.
Fifteen high-quality studies including 14 cohort studies and one case-control study were included in the meta-analysis. Compared with non-eosinophilic AECOPD patients, those with eosinophilic AECOPD had a lower risk of mortality (RR = 0.65, 95 % confidence interval [CI] 0.54, 0.77, P < 0.001), shorter length of hospital stay (WMD = −1.56, 95%CI -2.16, −0.96, P < 0.001), and higher readmission rate (RR = 1.07, 95%CI 1.01,1.13, P = 0.029). No difference was found concerning the rate of hospitalization and invasive mechanical ventilation between the two groups.
Individuals diagnosed with eosinophilic AECOPD had a reduced mortality rate, a truncated period of hospitalization, and an insubstantial increase in the probability of readmission relative to their non-eosinophilic AECOPD counterparts. The level of eosinophils in blood has been shown to serve as a potential predictive biomarker for AECOPD patients.
•Eosinophilia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with improved outcomes, including lower mortality risk and shorter hospital stay.•Patients with eosinophilic AECOPD have higher readmission rates, highlighting the importance of post-discharge monitoring.•Peripheral blood eosinophil count could be a valuable biomarker for predicting prognosis and tailoring individualized treatment in AECOPD.•This systematic review and meta-analysis provide robust evidence supporting the role of eosinophils in AECOPD, aiding clinicians in understanding disease pathogenesis and optimizing patient management.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38104787</pmid><doi>10.1016/j.rmed.2023.107501</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-6111 |
| ispartof | Respiratory medicine, 2024-02, Vol.222, p.107501, Article 107501 |
| issn | 0954-6111 1532-3064 1532-3064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2903323697 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood eosinophils Case-Control Studies Chronic obstructive pulmonary disease Disease Progression Eosinophils Hospitalization Humans Observational studies Pulmonary Disease, Chronic Obstructive - diagnosis |
| title | The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T13%3A21%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20association%20between%20blood%20eosinophils%20and%20clinical%20outcome%20of%20acute%20exacerbations%20of%20chronic%20obstructive%20pulmonary%20disease:%20A%20systematic%20review%20and%20meta-analysis&rft.jtitle=Respiratory%20medicine&rft.au=Liu,%20Hai&rft.date=2024-02&rft.volume=222&rft.spage=107501&rft.pages=107501-&rft.artnum=107501&rft.issn=0954-6111&rft.eissn=1532-3064&rft_id=info:doi/10.1016/j.rmed.2023.107501&rft_dat=%3Cproquest_cross%3E2903323697%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2903323697&rft_id=info:pmid/38104787&rft_els_id=S095461112300389X&rfr_iscdi=true |