A Solitary Stalled 80S Ribosome Prevents mRNA Recruitment to Stress Granules

In response to stress stimuli, eukaryotic cells typically suppress protein synthesis. This leads to the release of mRNAs from polysomes, their condensation with RNA-binding proteins, and the formation of non-membrane-bound cytoplasmic compartments called stress granules (SGs). SGs contain 40S but ge...

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Veröffentlicht in:	Biochemistry (Moscow) 2023-11, Vol.88 (11), p.1786-1799
Hauptverfasser:	Fedorovskiy, Artem G., Burakov, Anton V., Terenin, Ilya M., Bykov, Dmitry A., Lashkevich, Kseniya A., Popenko, Vladimir I., Makarova, Nadezhda E., Sorokin, Ivan I., Sukhinina, Anastasia P., Prassolov, Vladimir S., Ivanov, Pavel V., Dmitriev, Sergey E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anisomycin Arsenite Binding Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cycloheximide Cytoplasmic Granules Elongation Emetine Genetic aspects Granular materials Health aspects Inhibitors Life Sciences Messenger RNA Microbiology mRNA Oxidative stress Polyribosomes Protein Biosynthesis Protein synthesis Protein Synthesis Inhibitors - pharmacology Proteins Puromycin Ribonucleic acid Ribosomal subunits Ribosomes Ribosomes - metabolism RNA RNA, Messenger - metabolism RNA-binding protein RNA-Binding Proteins - metabolism Sodium arsenite Stress (Physiology) Stress Granules Stress response Toxins Translation initiation
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