Electrokinetic focusing of SARS-CoV-2 spike protein via ion concentration polarization in a paper-based lateral flow assay

The COVID-19 pandemic highlighted the importance of designing sensitive and selective point-of-care (POC) diagnostic sensors for early and rapid detection of infection. Paper-based lateral flow assays (LFAs) are easy to use, inexpensive, and rapid, but they lack sensitivity. Preconcentration techniq...

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Veröffentlicht in:	Analytical methods 2023-12, Vol.16 (1), p.91-104
Hauptverfasser:	Rahn, Kira L, Osman, Sommer Y, Pollak, Quinlan G, Anand, Robbyn K
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin Angiotensin-converting enzyme 2 Biomolecules COVID-19 COVID-19 - diagnosis Depletion Electric field strength Electric fields Electric potential Enrichment Fluid flow Humans Ion concentration Ions Migratory species Pandemics Peptidyl-dipeptidase A Polarization Power consumption Protein folding Proteins SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike protein Viral diseases Voltage
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