Effect of zinc oxide micro- and nanoparticles on cytotoxicity, antimicrobial activity and mechanical properties of apatite-polymer osteoplastic material
This work is devoted to the comparison of the physical and biological properties of synthesized osteoplastic composites with an experimentally determined content (375 μg/g) of the micro (ZnO ) and nano (ZnO ) particles, immobilized in Hydroxyapatite-Alginate-Chitosan matrix (HA-Alg-CS). ZnO show pro...
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| Veröffentlicht in: | Journal of the mechanical behavior of biomedical materials 2024-02, Vol.150, p.106289, Article 106289 |
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| creator | Sukhodub, Liudmyla Kumeda, Mariia Sukhodub, Leonid Vovchenko, Liudmyla Prokopiuk, Volodymyr Petrenko, Oleksander Kovalenko, Igor Pshenychnyi, Roman Opanasyuk, Anatoliy |
| description | This work is devoted to the comparison of the physical and biological properties of synthesized osteoplastic composites with an experimentally determined content (375 μg/g) of the micro (ZnO
) and nano (ZnO
) particles, immobilized in Hydroxyapatite-Alginate-Chitosan matrix (HA-Alg-CS). ZnO
show pronounced antimicrobial activity against E.coli ATCC 25922 and S. aureus ATCC 25923, while ZnO
only in the CS presence. Composites containing ZnO
do not have a toxic effect on bone-forming cells - osteoblasts, preserving their ability to biomineralization. ZnO
and ZnO
to varying degrees, but significantly affect composites' swelling, porosity, shape stability, and prolong vitamin D3 release for 120h, compared to Control. Composites do not demonstrate unwanted "burst release." ZnO
increase Youngs' modulus of the HA-Alg matrix, namely 348 → 419 MPa (ZnO
), 348 → 646 MPa (ZnO
), and weaken the plastic (irreversible) deformations. The compressive strength of HA-Alg and HA-Alg/CS matrixes containing ZnO
(178 MPa and 251 MPa, respectively) is in the range of values for native cortical bone (170-193 MPa). Biocompatibility and lack of toxic effect give both composites a perspective for osteoplastic application, but composites doped with ZnO
are more attractive. |
| doi_str_mv | 10.1016/j.jmbbm.2023.106289 |
| format | Article |
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) and nano (ZnO
) particles, immobilized in Hydroxyapatite-Alginate-Chitosan matrix (HA-Alg-CS). ZnO
show pronounced antimicrobial activity against E.coli ATCC 25922 and S. aureus ATCC 25923, while ZnO
only in the CS presence. Composites containing ZnO
do not have a toxic effect on bone-forming cells - osteoblasts, preserving their ability to biomineralization. ZnO
and ZnO
to varying degrees, but significantly affect composites' swelling, porosity, shape stability, and prolong vitamin D3 release for 120h, compared to Control. Composites do not demonstrate unwanted "burst release." ZnO
increase Youngs' modulus of the HA-Alg matrix, namely 348 → 419 MPa (ZnO
), 348 → 646 MPa (ZnO
), and weaken the plastic (irreversible) deformations. The compressive strength of HA-Alg and HA-Alg/CS matrixes containing ZnO
(178 MPa and 251 MPa, respectively) is in the range of values for native cortical bone (170-193 MPa). Biocompatibility and lack of toxic effect give both composites a perspective for osteoplastic application, but composites doped with ZnO
are more attractive.</description><identifier>ISSN: 1751-6161</identifier><identifier>ISSN: 1878-0180</identifier><identifier>EISSN: 1878-0180</identifier><identifier>DOI: 10.1016/j.jmbbm.2023.106289</identifier><identifier>PMID: 38070451</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Anti-Infective Agents ; Apatites ; Nanoparticles ; Staphylococcus aureus ; Zinc Oxide - toxicity</subject><ispartof>Journal of the mechanical behavior of biomedical materials, 2024-02, Vol.150, p.106289, Article 106289</ispartof><rights>Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-e925b55f44c50681f4fe39ac4628ad01cd101c794010c5c670524c58d174a5653</citedby><cites>FETCH-LOGICAL-c350t-e925b55f44c50681f4fe39ac4628ad01cd101c794010c5c670524c58d174a5653</cites><orcidid>0000-0002-9350-5766 ; 0000-0002-1888-3935 ; 0000-0003-4379-4130 ; 0000-0002-2560-9379 ; 0000-0002-1559-0475 ; 0000-0002-8480-9223</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38070451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sukhodub, Liudmyla</creatorcontrib><creatorcontrib>Kumeda, Mariia</creatorcontrib><creatorcontrib>Sukhodub, Leonid</creatorcontrib><creatorcontrib>Vovchenko, Liudmyla</creatorcontrib><creatorcontrib>Prokopiuk, Volodymyr</creatorcontrib><creatorcontrib>Petrenko, Oleksander</creatorcontrib><creatorcontrib>Kovalenko, Igor</creatorcontrib><creatorcontrib>Pshenychnyi, Roman</creatorcontrib><creatorcontrib>Opanasyuk, Anatoliy</creatorcontrib><title>Effect of zinc oxide micro- and nanoparticles on cytotoxicity, antimicrobial activity and mechanical properties of apatite-polymer osteoplastic material</title><title>Journal of the mechanical behavior of biomedical materials</title><addtitle>J Mech Behav Biomed Mater</addtitle><description>This work is devoted to the comparison of the physical and biological properties of synthesized osteoplastic composites with an experimentally determined content (375 μg/g) of the micro (ZnO
) and nano (ZnO
) particles, immobilized in Hydroxyapatite-Alginate-Chitosan matrix (HA-Alg-CS). ZnO
show pronounced antimicrobial activity against E.coli ATCC 25922 and S. aureus ATCC 25923, while ZnO
only in the CS presence. Composites containing ZnO
do not have a toxic effect on bone-forming cells - osteoblasts, preserving their ability to biomineralization. ZnO
and ZnO
to varying degrees, but significantly affect composites' swelling, porosity, shape stability, and prolong vitamin D3 release for 120h, compared to Control. Composites do not demonstrate unwanted "burst release." ZnO
increase Youngs' modulus of the HA-Alg matrix, namely 348 → 419 MPa (ZnO
), 348 → 646 MPa (ZnO
), and weaken the plastic (irreversible) deformations. The compressive strength of HA-Alg and HA-Alg/CS matrixes containing ZnO
(178 MPa and 251 MPa, respectively) is in the range of values for native cortical bone (170-193 MPa). Biocompatibility and lack of toxic effect give both composites a perspective for osteoplastic application, but composites doped with ZnO
are more attractive.</description><subject>Anti-Infective Agents</subject><subject>Apatites</subject><subject>Nanoparticles</subject><subject>Staphylococcus aureus</subject><subject>Zinc Oxide - toxicity</subject><issn>1751-6161</issn><issn>1878-0180</issn><issn>1878-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc2O1DAQhC0EYpeFJ0BCPnIgQzuJE-eIVsuPtBIXOFtOpy08iuMQexDDk-zj0jOzcLLV-qrarhLitYKdAtW93-_2cRzjroa64UlXm-GJuFamNxUoA0_53mtVdapTV-JFznuADsCY5-KqMdBDq9W1eLjznrDI5OWfsKBMv8NEMgbcUiXdMsnFLWl1Wwk4U5ZpkXgsqTCGoRzfMVLCmR6Dm6XDEn7x_KyMhD_cEpDn65ZWYo-Tg5dudSUUqtY0HyNtMuVCaZ1d5iUyukIbe70Uz7ybM716PG_E9493324_V_dfP325_XBfYaOhVDTUetTaty1q6IzyradmcNhyHG4ChRNnhf3QggLU2PWga0bNpPrW6U43N-LtxZff-PNAudgYMtI8u4XSIdt6gHroOVvDaHNB-bs5b-TtuoXotqNVYE-V2L09V2JPldhLJax687jgMEaa_mv-ddD8BUS8jD8</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Sukhodub, Liudmyla</creator><creator>Kumeda, Mariia</creator><creator>Sukhodub, Leonid</creator><creator>Vovchenko, Liudmyla</creator><creator>Prokopiuk, Volodymyr</creator><creator>Petrenko, Oleksander</creator><creator>Kovalenko, Igor</creator><creator>Pshenychnyi, Roman</creator><creator>Opanasyuk, Anatoliy</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9350-5766</orcidid><orcidid>https://orcid.org/0000-0002-1888-3935</orcidid><orcidid>https://orcid.org/0000-0003-4379-4130</orcidid><orcidid>https://orcid.org/0000-0002-2560-9379</orcidid><orcidid>https://orcid.org/0000-0002-1559-0475</orcidid><orcidid>https://orcid.org/0000-0002-8480-9223</orcidid></search><sort><creationdate>202402</creationdate><title>Effect of zinc oxide micro- and nanoparticles on cytotoxicity, antimicrobial activity and mechanical properties of apatite-polymer osteoplastic material</title><author>Sukhodub, Liudmyla ; Kumeda, Mariia ; Sukhodub, Leonid ; Vovchenko, Liudmyla ; Prokopiuk, Volodymyr ; Petrenko, Oleksander ; Kovalenko, Igor ; Pshenychnyi, Roman ; Opanasyuk, Anatoliy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-e925b55f44c50681f4fe39ac4628ad01cd101c794010c5c670524c58d174a5653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anti-Infective Agents</topic><topic>Apatites</topic><topic>Nanoparticles</topic><topic>Staphylococcus aureus</topic><topic>Zinc Oxide - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukhodub, Liudmyla</creatorcontrib><creatorcontrib>Kumeda, Mariia</creatorcontrib><creatorcontrib>Sukhodub, Leonid</creatorcontrib><creatorcontrib>Vovchenko, Liudmyla</creatorcontrib><creatorcontrib>Prokopiuk, Volodymyr</creatorcontrib><creatorcontrib>Petrenko, Oleksander</creatorcontrib><creatorcontrib>Kovalenko, Igor</creatorcontrib><creatorcontrib>Pshenychnyi, Roman</creatorcontrib><creatorcontrib>Opanasyuk, Anatoliy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukhodub, Liudmyla</au><au>Kumeda, Mariia</au><au>Sukhodub, Leonid</au><au>Vovchenko, Liudmyla</au><au>Prokopiuk, Volodymyr</au><au>Petrenko, Oleksander</au><au>Kovalenko, Igor</au><au>Pshenychnyi, Roman</au><au>Opanasyuk, Anatoliy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of zinc oxide micro- and nanoparticles on cytotoxicity, antimicrobial activity and mechanical properties of apatite-polymer osteoplastic material</atitle><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle><addtitle>J Mech Behav Biomed Mater</addtitle><date>2024-02</date><risdate>2024</risdate><volume>150</volume><spage>106289</spage><pages>106289-</pages><artnum>106289</artnum><issn>1751-6161</issn><issn>1878-0180</issn><eissn>1878-0180</eissn><abstract>This work is devoted to the comparison of the physical and biological properties of synthesized osteoplastic composites with an experimentally determined content (375 μg/g) of the micro (ZnO
) and nano (ZnO
) particles, immobilized in Hydroxyapatite-Alginate-Chitosan matrix (HA-Alg-CS). ZnO
show pronounced antimicrobial activity against E.coli ATCC 25922 and S. aureus ATCC 25923, while ZnO
only in the CS presence. Composites containing ZnO
do not have a toxic effect on bone-forming cells - osteoblasts, preserving their ability to biomineralization. ZnO
and ZnO
to varying degrees, but significantly affect composites' swelling, porosity, shape stability, and prolong vitamin D3 release for 120h, compared to Control. Composites do not demonstrate unwanted "burst release." ZnO
increase Youngs' modulus of the HA-Alg matrix, namely 348 → 419 MPa (ZnO
), 348 → 646 MPa (ZnO
), and weaken the plastic (irreversible) deformations. The compressive strength of HA-Alg and HA-Alg/CS matrixes containing ZnO
(178 MPa and 251 MPa, respectively) is in the range of values for native cortical bone (170-193 MPa). Biocompatibility and lack of toxic effect give both composites a perspective for osteoplastic application, but composites doped with ZnO
are more attractive.</abstract><cop>Netherlands</cop><pmid>38070451</pmid><doi>10.1016/j.jmbbm.2023.106289</doi><orcidid>https://orcid.org/0000-0002-9350-5766</orcidid><orcidid>https://orcid.org/0000-0002-1888-3935</orcidid><orcidid>https://orcid.org/0000-0003-4379-4130</orcidid><orcidid>https://orcid.org/0000-0002-2560-9379</orcidid><orcidid>https://orcid.org/0000-0002-1559-0475</orcidid><orcidid>https://orcid.org/0000-0002-8480-9223</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anti-Infective Agents Apatites Nanoparticles Staphylococcus aureus Zinc Oxide - toxicity |
| title | Effect of zinc oxide micro- and nanoparticles on cytotoxicity, antimicrobial activity and mechanical properties of apatite-polymer osteoplastic material |
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