Transcriptomic profiling of Polycystic Kidney Disease identifies paracrine factors in the early cyst microenvironment

Initial cysts that are formed upon Pkd1 loss in mice impose persistent stress on surrounding tissue and trigger a cystic snowball effect, in which local aberrant PKD-related signaling increases the likelihood of new cyst formation, ultimately leading to accelerated disease progression. Although many...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-02, Vol.1870 (2), p.166987-166987, Article 166987
Hauptverfasser:	Yasinoglu, Sevtap A, Kuipers, Thomas B, Suidgeest, Ernst, van der Weerd, Louise, Mei, Hailiang, Baelde, Hans J, Peters, Dorien J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cysts - genetics Gene Expression Profiling Kidney - metabolism Mice Polycystic Kidney Diseases - genetics Polycystic Kidney Diseases - metabolism Tumor Microenvironment
Online-Zugang:	Volltext
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