Reversible SAHH inhibitor ameliorates MIA-induced osteoarthritis of rats through suppressing MEK/ERK pathway

Osteoarthritis (OA) is characterized by gradual articular cartilage degradation, accompanied by persistent low-grade joint inflammation, correlating with radiographic and pain-related progression. The latent therapeutic potential of DZ2002, a reversible inhibitor of S-adenosyl-L-homocysteine hydrola...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-01, Vol.170, p.115975-115975, Article 115975
Hauptverfasser:	Fan, Shu-Hui, Chang, Yuan, Xiong, Xiao-Yu, Xiang, Mai, Yuan, Wen-Long, Yang, Xiao-Qian, Wei, Wen-Hui, Chen, Li, Cheng, Meng-Nan, Zhu, Feng-Hua, He, Shi-Jun, Zuo, Jian-Ping, Lin, Ze-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone resorption DZ2002 Osteoarthritis Osteoclast
Online-Zugang:	Volltext
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