In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

Dendritic cells (DCs), professional antigen-presenting cells, play an important role in pathologies by controlling adaptive immune responses. However, their adaptation to and functionality in hypercholesterolemia, a driving factor in disease onset and progression of atherosclerosis remains to be est...

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Veröffentlicht in:	Free radical biology & medicine 2024-01, Vol.210, p.406-415
Hauptverfasser:	Christ, Anette, Maas, Sanne L., Jin, Han, Lu, Chang, Legein, Bart, Wijnands, Erwin, Temmerman, Lieve, Otten, Jeroen, Isaacs, Aaron, Zenke, Martin, Stoll, Monika, Biessen, Erik A.L., van der Vorst, Emiel P.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - metabolism Dendritic Cells Hypercholesterolemia Hypercholesterolemia - genetics Lipids Mice Reactive Oxygen Species - metabolism ROS accumulation T cell priming T-Lymphocytes
Online-Zugang:	Volltext
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