The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction

Brugada syndrome is associated with loss-of-function variants, yet these account for only ≈20% of cases. A recent genome-wide association study identified a novel locus within , which encodes EB2 (microtubule end-binding protein 2), implicating microtubule involvement in Brugada syndrome. A knockout...

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Veröffentlicht in:	Circulation research 2024-01, Vol.134 (1), p.46-59
Hauptverfasser:	Chiang, David Y, Verkerk, Arie O, Victorio, Rachelle, Shneyer, Boris I, van der Vaart, Babet, Jouni, Mariam, Narendran, Nakul, Kc, Ashmita, Sampognaro, James R, Vetrano-Olsen, Franki, Oh, John S, Buys, Eva, de Jonge, Berend, Shah, Disheet A, Kiviniemi, Tuomas, Burridge, Paul W, Bezzina, Connie R, Akhmanova, Anna, MacRae, Calum A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Brugada Syndrome - genetics Brugada Syndrome - metabolism Genome-Wide Association Study Humans Induced Pluripotent Stem Cells - metabolism Microtubule-Associated Proteins - genetics Microtubules - metabolism Myocytes, Cardiac - metabolism NAV1.5 Voltage-Gated Sodium Channel - genetics NAV1.5 Voltage-Gated Sodium Channel - metabolism Tubulin - genetics Tubulin - metabolism Voltage-Gated Sodium Channels - metabolism Zebrafish - genetics Zebrafish - metabolism
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