Anoctamin-1 is induced by TGF-β and contributes to lung myofibroblast differentiation

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs and resulting in deterioration in lung function. Transforming growth factor-β (TGF-β) is one of the most established drivers of fibrotic processes. TGF-β promotes the transformation of tis...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2024-01, Vol.326 (1), p.L111-L123
Hauptverfasser:	Reed, Eleanor B, Orbeta, Shaina, Miao, Bernadette A, Sitikov, Albert, Chen, Bohao, Levitan, Irena, Solway, Julian, Mutlu, Gökhan M, Fang, Yun, Mongin, Alexander A, Dulin, Nickolai O
Format:	Artikel
Sprache:	eng
Schlagworte:	Anoctamin-1 - metabolism Cell Differentiation Chlorides - metabolism Fibroblasts - metabolism Humans Idiopathic Pulmonary Fibrosis - pathology Lung - metabolism Myofibroblasts - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta1 - metabolism Transforming Growth Factors - metabolism Transforming Growth Factors - pharmacology
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