Machine Learning‐Led Optimization of Combination Therapy: Confronting the Public Health Threat of Extensively Drug Resistant Gram‐Negative Bacteria

Developing optimized regimens for combination antibiotic therapy is challenging and often performed empirically over many clinical studies. Novel implementation of a hybrid machine‐learning pharmacokinetic/pharmacodynamic/toxicodynamic (ML‐PK/PD/TD) approach optimizes combination therapy using human...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2024-04, Vol.115 (4), p.896-905
Hauptverfasser:	Smith, Nicholas M., Nguyen, Thomas D., Lodise, Thomas P., Chen, Liang, Kaur, Jan Naseer, Klem, John F., Boissonneault, Katie Rose, Holden, Patricia N., Roach, Dwayne R., Tsuji, Brian T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - adverse effects Aztreonam - pharmacology Gram-Negative Bacteria Humans Polymyxin B Public Health
Online-Zugang:	Volltext
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