Ensuring quality in 17OHP mass spectrometry measurement: an international study assessing isomeric steroid interference

Interference from isomeric steroids is a potential cause of disparity between mass spectrometry-based 17-hydroxyprogesterone (17OHP) results. We aimed to assess the proficiency of mass spectrometry laboratories to report 17OHP in the presence of known isomeric steroids. A series of five samples were...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2024-04, Vol.62 (5), p.911-918
Hauptverfasser:	Ho, Chung Shun, Hoad, Kirsten, Cooke, Brian R., Andersen, Trisha, Graham, Peter, van den Berg, Sjoerd A.A., Hartmann, Michaela F., Lo, Clara W.S., Loh, Tze Ping, de Rijke, Yolanda B., van Zelst, Bertrand D., Wudy, Stefan A., Zakaria, Rosita, Greaves, Ronda F.
Format:	Artikel
Sprache:	eng
Schlagworte:	17-alpha-Hydroxyprogesterone 17OHP 17α-hydroxyprogesterone Biomarkers Chromatography Chromatography, Liquid - methods Endocrinology Gas chromatography Humans Hydroxyprogesterones Interference International studies isobars Isomers Laboratories Liquid chromatography Mass spectrometry Mass spectroscopy Medical screening method validation Pediatrics Progesterone Quality assurance Quality control Scientific imaging Sensitivity and Specificity Steroid hormones Steroids Tandem Mass Spectrometry - methods
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